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Nuclear CMPK1 expression is indicative of poor prognosis in the triple negative breast cancer patients.
TGF-b1 inhibited the expression of CMPK, which was blocked in the presence of a TGF-b type I receptor, SB431542, and was abolished by the inhibitor of miR-130b-3p, indicating that CMPK is regulated by the TGF-b signalling pathway through the upregulation of miR-130b-3p.
The role of CMP/UMP kinase (CMPK), an enzyme catalyzes cytidine diphosphate formation, in DNA repair, was investigated.
CMPK1 and RBP3 are associated with corneal curvature in Asian populations.
In particular, polymorphisms of the CMPK1 gene seem to provide important prognostic information
Single-nucleotide polymorphisms in CMPK1 gene is associated with treatment response in non-small cell lung cancer.
UMP/CMP kinase (EC 126.96.36.199) is not critical for the phosphorylation of CMP, dCMP and maintenance of natural nucleotide pools in cells
thymidylate synthase/ribonucleotide reductase gene silencing and deoxycytidine kinase::uridine monophosphate kinase fusion gene gene overexpression markedly improved gemcitabine's therapeutic activity
Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates.
UMP/CMP kinase reveals the conformational changes that occur upon substrate binding
Models for the phosphorylation action and substrate specificity of human UMP/CMP kinase.
Several uracil vinylphosphonate derivatives had affinities for human UMP-CMP kinase similar to those of dUMP
This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants.
, UMP/CMP kinase
, cytidylate kinase
, dCMP kinase
, deoxycytidylate kinase
, uridine monophosphate kinase
, uridine monophosphate/cytidine monophosphate kinase
, cytidine monophosphate kinase
, CMP kinase
, UMP-CMP kinase 1
, cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
, cytidylate kinase 1
, likely ortholog of H. sapiens UMP-CMP kinase (UMP-CMPK)
, Deoxycytidylate kinase
, Nucleoside-diphosphate kinase
, Uridine monophosphate/cytidine monophosphate kinase