Recommendations are based on data provided indicating:
ELISA Kit Sensitivity
The recommended ELISA Kit will likely detect the antigen better in the approved sample types than the available alternatives.
ELISA Kit Specificity
The recommended ELISA Kit will likely detect the antigen in question with higher specificity in approved samples than the available alternatives.
The results will be likely more reproducible, with high inter- or intra-assay CV and Recovery (for values within the std curve) than the available alternatives.
ELISA Kit Robustness
The recommended assay will likely function better with approved sample types, and will not suffer from undue matrix interference than the available alternatives.
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BAX Antigen Profile
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Alternative names and synonyms associated with BAX
BCL2-associated X protein
, BCL2-associated protein
, apoptosis regulator BAX
, bax zeta
, BCL2-associated X protein omega
, BCL2-associated X protein transcript variant delta2
, bcl-2-like protein 4