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anti-Human E2F1 Antibodies:
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Human Polyclonal E2F1 Primary Antibody for WB - ABIN3044440
Zhou, Lu, Liu, Guo, Liu, Zhou, Yang, Mi, Xu: Platycodin D induces tumor growth arrest by activating FOXO3a expression in prostate cancer in vitro and in vivo. in Current cancer drug targets 2015
Show all 3 Pubmed References
Human Monoclonal E2F1 Primary Antibody for FACS, IHC - ABIN969516
Okazaki, Matsunaga, Okazaki, Utoguchi, Suzuki, Maruyama, Koyanagi, Ohdo: Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice. in Cancer research 2010
Show all 3 Pubmed References
Human Monoclonal E2F1 Primary Antibody for ELISA, WB - ABIN3201010
Irwin, Marin, Phillips, Seelan, Smith, Liu, Flores, Tsai, Jacks, Vousden, Kaelin: Role for the p53 homologue p73 in E2F-1-induced apoptosis. in Nature 2000
Show all 3 Pubmed References
Human Monoclonal E2F1 Primary Antibody for ICC, IF - ABIN153153
Liu, Clements, Zhao, Marmorstein: Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor. in The Journal of biological chemistry 2006
Show all 2 Pubmed References
Human Polyclonal E2F1 Primary Antibody for ELISA, WB - ABIN2746554
Wang, Dou, Yao, Song: Homocysteine inhibits adipogenesis in 3T3-L1 preadipocytes. in Experimental biology and medicine (Maywood, N.J.) 2012
Human Polyclonal E2F1 Primary Antibody for WB - ABIN391858
ODonnell, Wentzel, Zeller, Dang, Mendell: c-Myc-regulated microRNAs modulate E2F1 expression. in Nature 2005
Show all 6 Pubmed References
Human Polyclonal E2F1 Primary Antibody for IF (p), IHC (p) - ABIN670686
Liu, Yang, Jing, Ren, Wei, Zhang, Zhang, Duan, Zhou, Sun: Silica nanoparticle exposure inducing granulosa cell apoptosis and follicular atresia in female Balb/c mice. in Environmental science and pollution research international 2017
Human Polyclonal E2F1 Primary Antibody for ELISA, ICC - ABIN6261409
Xia, Wang, Song, Meng, Huang, Huang: Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2). in Journal of experimental & clinical cancer research : CR 2018
Human Monoclonal E2F1 Primary Antibody for ICC, IF - ABIN269710
Zhang, Zhang, Yao, Lowery, Zhang, Huang, Li, Li, Wang, Zhang, Wang, Ellis, Cheerathodi, McCarty, Palmieri, Saunus, Lakhani, Huang, Sahin, Aldape, Steeg, Yu: Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. in Nature 2015
Human Polyclonal E2F1 Primary Antibody for IHC, IHC (p) - ABIN4306768
Zellmer, Schmidt-Heck, Godoy, Weng, Meyer, Lehmann, Sparna, Schormann, Hammad, Kreutz, Timmer, von Weizsäcker, Thürmann, Merfort, Guthke, Dooley, Hengstler, Gebhardt: Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes. in Hepatology (Baltimore, Md.) 2010
dE2F1b is a novel member of the E2F (show E2F2 Antibodies) family, revealing a previously unappreciated complexity in the Drosophila RB/E2F (show E2F2 Antibodies) network.
specific alternate transcripts of activator E2F (show E2F2 Antibodies), dE2F1, may have a dual function on cell cycle progression and cannot simply be viewed as a pro-proliferative transcription factor
These findings identify a key function of E2F in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells.
Mechanistically, miR (show MYLIP Antibodies)-998 operates by repressing dCbl, a negative regulator of EGFR (show EGFR Antibodies) signaling. Significantly, dCbl is a critical target of miR (show MYLIP Antibodies)-998 since dCbl phenocopies the effects of miR (show MYLIP Antibodies)-998 on dE2f1-dependent apoptosis in rbf (show ATP5I Antibodies) mutants
also demonstrated that an optimum level of dLin52 is needed for dE2F1/2 activity on the hid promoter
Results show that regulation of e2f1 and PCNA (show PCNA Antibodies) by DREF (show ZBED1 Antibodies) in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.
Loss of dE2F compromises mitochondrial function.
Data propose that the interaction between ORC5 (show ORC5 Antibodies) and dE2F1 may reflect a feedback mechanism between replication initiation proteins and dE2F1 that ensures that proliferating cells maintain a robust level of replication proteins for the next cell cycle.
results suggest that E2F/DP complexes are essential for all genomic targeting of RBF1
Inappropriate accumulation of E2f1 protein during S phase triggers the elimination of potentially hyperplastic cells via apoptosis in order to ensure normal development of rapidly proliferating tissues.
PPM1B (show PPM1B Antibodies) plays a negative role in the activation of the p38 (show CRK Antibodies)-RB1 (show RB1 Antibodies)-E2F1 pathway and that targeting PPM1B (show PPM1B Antibodies) could be useful in certain types of cancer by stimulating chemotherapy-induced cell death.
Studied impact of BET proteins and E2F transcription factor 1 (E2F1) in neoplastic genetic transcription in glioblastoma.
E2F1 knockdown decreased the expression of discoidin domain receptor (show DDR1 Antibodies) 1 (DDR1 (show DDR1 Antibodies)) which plays a crucial role in many fundamental processes such as cell differentiation, adhesion, migration and invasion.
Our data imply that downregulation of E2F1 may be a key factor in the celastrol-mediated inhibitory effects in HepG2 cells, and celastrol can serve as a leading compound for the development of compounds designed to inactivate E2F1 for hepatocellular carcinoma therapy
SNHG16 promotes glioma tumorigenesis by sponging miR (show MLXIP Antibodies)-20a-5p, leading to the enhancement of its endogenous targets E2F1
These results demonstrate that gambogic acid sensitizes pancreatic cancer cells to gemcitabine in vitro and in vivo by inhibiting the activation of the ERK (show EPHB2 Antibodies)/E2F1/RRM2 (show RRM2 Antibodies) signaling pathway.
Reports showed that high expression of the transcription factor E2F1 was involved in the invasion and metastasis of small cell lung cancer (SCLC). Further results provided evidence that E2F1 promoted EMT (show ITK Antibodies) by regulating ZEB2 (show ZEB2 Antibodies) gene expression in SCLC.
By comparison in HeLa, Dox induced apoptosis through upregulation of endogenous E2F1 involving post-transcriptional mechanisms, while E2F6 (show E2F6 Antibodies) was down regulated with induction of the Checkpoint kinase-1 (show CHEK1 Antibodies) and proteasome degradation. These data imply that E2F6 (show E2F6 Antibodies) serves to modulate E2F activity and protect cells including cardiomyocytes from apoptosis and improve survival.
This study reveals a molecular pathway involving lncRNA GAS5/E2F1/P27(Kip1 (show CDKN1B Antibodies)) which regulates cell proliferation and could be a potential therapeutic target in prostate cancer.
E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1 (show STAU1 Antibodies)/CDKN2B (show CDKN2B Antibodies) signaling axis.
E2f1 mediates high glucose-induced neuronal death in cultured mouse retinal explants.
p63alpha protein up-regulates heat shock protein 70 (show HSP70 Antibodies) expression via E2F1 transcription factor 1 (show HNF1A Antibodies), promoting Wasf3/Wave3 (show WASF3 Antibodies)/MMP9 (show MMP9 Antibodies) signaling and bladder cancer invasion
The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 to recruit EZH2 (show EZH2 Antibodies) to diverse repeat sequences.
germ-line loss of E2f1 or E2f3b, but not E2f3a, protected mice against hepatocellular carcinoma
E2F1 hinders skin wound healing by suppressing VEGF (show VEGFA Antibodies) expression, neovascularization, and macrophage recruitment. Strategies that target E2F1 may enhance wound healing.
systems-level control of cell cycle arrest by pRB (show PGR Antibodies)-E2F and p27 (show CDKN1B Antibodies)-CDK (show CDK4 Antibodies) regulation, is reported.
TERT (show TERT Antibodies) has a role in neointima formation through epigenetic regulation of proliferative E2F1 target gene expression in smooth muscle cells.
inhibition of PDK4 (show PDK4 Antibodies) activity in Hepatocellular carcinoma cells increased cyclin E1 (show CCNE1 Antibodies), cyclin A2 (show CCNA2 Antibodies), and E2F1 proteins.
Data indicate that adenosine and CGS21680 upregulate CD39 (show ENTPD1 Antibodies) and CD73 via E2F-1 and CREB (show CREB1 Antibodies).
Expression of Kv10.1 (show KCNG3 Antibodies) driven by phosphorylated Rb/E2F1 contributes to G2/M progression of cancer and non-transformed cells.
Xphb1 represses E2F1 activity.
SIM (show SIM2 Antibodies) and SMR1 are involved in hyperphosphorylation of the cell-cycle regulator RBR1 and overexpression of E2F target genes.
S6K1 interacts with retinoblastoma protein RBR via its N-terminal RBR binding motif, promotes its nuclear localization and consequent RBR-dependent repression of cell cycle genes through transcription factor E2FB.
The Arabidopsis (Arabidopsis thaliana) DEL1 gene was identified as a transcriptional target of the classical E2Fb and E2Fc transcription factors.
The authors found that S6K1 associates with the Retinoblastoma-related 1 (RBR1)-E2FB complex and this is partly mediated by its N-terminal LVxCxE motif.
Results suggest that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA.
AtE2Fa and AtE2Fb have specific expression patterns and may play similar but distinct roles during cell cycle progression.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
, E2-promoter binding factor
, PRB-binding protein E2F-1
, retinoblastoma-associated protein 1
, retinoblastoma-binding protein 3
, transcription factor E2F1
, E2F-1 transcription factor