Browse our anti-HMGB1 (HMGB1) Antibodies

Human High-Mobility Group Box 1 (HMGB1) interaction partners

1. Receiver operating characteristic curve (ROC) revealed HMGB1 had 32% sensitivity and 100% specificity in differentiating HCV from HCV+HCC patients, both SEPP1 and HMGB1 had high sensitivity (92%,60%) and 93% specificity in differentiating healthy from HCV+HCC group

2. These results could highlight a possible role of HMGB1 during birth time related to mode of delivery and labour.

3. HMGB1 secreted from airway epithelial cells can facilitate the secretion of proinflammatory mediators from immune cells in a paracrine mechanism, thus promoting the inflammatory response that contributes to respiratory syncytial virus pathogenesis

4. The higher levels of sTREM1 and HMGB1 cytokines in GCF of periodontitis patients and the significant decrease after the introduction of the periodontal treatment underlines the importance of HMGB1 and sTREM1 in pathogenesis of periodontitis.

5. Placental hypoxia-induced HMGB1 expression and release from trophoblasts are important mechanism underlying increased circulating endothelial microparticles and thrombophilia in preeclampsia.

6. HMGB1 was significantly higher in mild cognitive impairment (MCI) than controls. HMGB1 was associated with reduced cortical thickness in left lingual and bilateral superior frontal gyrus in MCI. APOE-varepsilon4 and HMGB1 have reduction in cortical thickness independently and have a more widespread cortical thinning in MCI when they interact.

7. Downregulation of HMGB1 could effectively inhibit proliferation, increase radiosensitivity, impair DNA damage repair abilities, reduce autophagy, and increase apoptosis rates in ESCC cells after irradiation.

8. High HMGB1 expression is associated with colorectal cancer stemness and development.

9. MiR-218-5p attenuated Henoch-Schonlein purpura at least partly through regulating HMGB1 expression and affecting the function of HUVECs.

10. The effect of post-translational modifications of the HMGB1 protein upon binding to platinated DNA has been analyzed.

11. Serum levels of total HMGB-1 and sRAGE were elevated in patients with Sjogren's syndrome compared to healthy controls and correlated with disease activity.

12. No statistical association between HMGB1 rs1045411, rs1360485, rs1412125, and rs2249825 polymorphisms and cancer risks.[meta-analysis]

13. Hyperbaric oxygen therapy therapy regulated the inflammatory reaction in secondary spinal cord injury by decreasing plasma HMGB1/NF-kappaB levels and reducing the dispersion of electromyogram F-waves of the lower limbs, thereby promoting neurological function recovery.

14. Serum high mobility group box 1 protein was significantly increased in patients with coronary artery disease in comparison to healthy subjects.

15. the level of HMGB1 in the sera of newborns can better predict the occurrence and death in neonatal respiratory distress syndrome

16. Investigated the function of miR-216a-5p in asthma by creating a bronchial epithelial cell (16HBE) injury model using HO. A significantly elevation of HMGB1 protein expression and a reduction of miR-216a-5p expression were observed in children with asthma as well as in HO stimulated 16HBE cells.

17. sRAGE could play a potential role in the control of inflammatory response in HTLV-1 carriers through the inhibition of HMGB1 signaling and potentially could be used as an indicator for evaluation of HTLV-1-associated myelopathy/tropical spastic paraparesis developing in HTLV-1-infected individuals.

18. HMGB1 localized in the cytoplasm of hepatocytes in surgically resected fibrotic liver samples.

19. We propose that the HMGB1 released after cell necrosis and in ischemic condition can trigger the classical pathway of complement activation to exacerbate sterile inflammation.

20. CH may have potential therapeutic effect in treating OA by protecting human osteoarthritis chondrocytes via HMGB1 suppression.

Mouse (Murine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. Taken together, the authors identified miR-181a-5p a negative regulator in HMGB1-induced immune responses by targeting TNF-alpha mRNA in dendritic cells.

2. Epac1 deacetylates HMGB1 through increased IGFBP-3 and SIRT1 levels in the retinal vasculature.

3. TGF-beta1 is a vital regulatory factor in denervated skeletal muscle in which HMGB1/ autophagy pathway mediates the atrophic effect of TGF-beta1

4. Findings indicate that high mobility group box 1 (HMGB1) interacts with lipopolysaccharide (LPS) to mediate caspase-11-dependent pyroptosis in lethal sepsis.

5. The data of this study showed that spinal HMGB1 was increased by ischemic stroke, and spinal HMGB1 colocalized with neurons but not microglia and astrocytes.

6. this study shows GSTP prevents sepsis-related HMGB1 Protein translocation and release

7. results indicate that HMGB1 may be an important contributor in the prevention and treatment of pneumonia of carbapenem-resistant-induced pneumonia

8. HMGB1 promotes lipopolysaccharide-induced peritoneal mesothelial cells apoptosis, which is associated with JNK1-mediated upregulation of HMGB1 acetylation.

9. Hepatocyte and Kupffer cell-derived HMGB1 participates in the pathogenesis of liver fibrosis by signaling through RAGE in hepatic stellate cells to activate the pMEK1/2, pERK1/2 and pcJun pathway and increase Collagen type I deposition.

10. DNA methyltransferases 1 (DNMT1) inhibits high-mobility group box 1(HMGB1) expression in hypoxia-induced apoptosis in cardiac progenitor cells (CPCs).

11. HMGB1 triggers immune reversal through the mobilization, redistribution, and local immune differentiation of bone marrow cells, thereby compensating for impaired immunity and leading to sufficient bacterial eradication in late-phase sepsis

12. CD11b contributes to the development of sepsis, predominantly by facilitating nucleocytoplasmic translocation and active release of HMGB1.

13. dysfunctional/diminished S1PR1 contributes to the retention of malignant cells in the surrounding tissue, constituting a minimal residual disease reservoir that later may give rise to a relapse. In DLBCL, mutations of S1PR1 have not yet been reported, but lack of membrane expression of S1PR1 in DLBCL at early stages (Ann Arbor I+II) correlates to superior outcome

14. Inhibition of NLRP3 inflammasome reduced HMGB1 expression.

15. In summary, we have demonstrated that the C-terminal tail of HMGB1 negatively regulates the interaction with TLR2.

16. High HMGB1 expression is associated with pulmonary fibrosis.

17. The up-regulation of HMGB1 was thought to be modified by dual channels: in the transcriptional level, it was regulated by JNK1/JNK2-ATF2 axis; post-transcriptionally, it was regulated by the microRNA (miR)-200 family, especially miR-429. miR-429 liver conditional knockout mice (miR-429(Deltahep)), fed either a normal diet or an HFD, showed severe liver inflammation and dysfunction, accompanied by greater expression of ...

18. This study suggested that bone cancer related hyperalgesia is driven by PKC induced phosphorylation of HMGB1, which results in its translocation from the nucleus, and releasing from the cytosol of the dorsal horn, and the activation of spinal pro-inflammatory mediators.

19. HMGB1 specifically induces the release of Th2 cytokines through GRP75-mediated enhancement of ER-Mitochondrial Ca(2+) transfer and ROS increased.

20. Results show that oxaliplatin treatment enhanced HMGB1 expression associated with immunosuppression in the colon.

Cow (Bovine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. HMGB1 can act as an adjuvant in modulating the bovine immune system and thus lays a foundation for using HMGB1 as an adjuvant in various bovine vaccine preparations.

2. Single-nucleotide polymorphism in the 3'-untranslated region of the HMGB1 gene affects the binding of target bta-miR-223 and is involved in mastitis.

3. The mechanisms of interaction of the non-histone chromosomal protein HMGB1 and linker histone H1 with DNA have been studied using circular dichroism and absorption spectroscopy.

4. HMGB1 is able to induce considerable changes in DNA structure upon binding even when the amount of the protein directly associated with DNA is low

5. Interaction between non-histone chromatin protein HMGB1 and linker histone H1

6. HMGB-1 might play a role in the pathological thickening of subchondral bone plate/osteophyte formation.

7. Analysis of mechanical response generated by binding of DNA-bending protein HMGB1 to single tethered 48.5 kb lambda-DNA molecules finds that compaction of DNA increases with increasing HMGB1 concentration.

8. Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin.

Zebrafish High-Mobility Group Box 1 (HMGB1) interaction partners

1. SCARA5 is an HMGB1 recognition receptor that is negatively involved in HMGB1-mediated inflammation in pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio) models.

2. HMGB1 is a critical factor for brain development, enabling survival and proliferation of neural progenitors that will form the forebrain structures.

Pig (Porcine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. Systemic HMGB-1 levels were significantly elevated in both trauma groups when compared to the sham group. Haemorrhagic shock severity and duration were positively correlated with HMGB-1 levels and compared to baseline values, concentrations remained significantly increased in severe hemorrhage when compared to moderate hemorrhage.

2. high levels of HMGB1 in the small intestine and its relation to high levels of HMGB1 in plasma of piglets infected with E. coli O55 that suffered from infection correlated with high levels of inflammatory cytokines and bacterial translocation; levels were higher than HMGB1 levels in piglets with mild clinical symptoms

3. HMGB-1 may participate in the inflammatory response and liver injury in the late stage of acute liver failure

Horse (Equine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. High mobility group box-1 and nucleosomes might have use as biomarkers for horses with gastrointestinal disease.

2. Extracellular HMGB-1 is widespread only in synovial membrane from diseased joints in horses with osteoarthritis.

3. Osteochondral injury was associated with a significant increase in synovial HMGB-1 concentrations in horses with joint injuries, compared with results for clinically normal horses.

Rabbit High-Mobility Group Box 1 (HMGB1) interaction partners

1. Airway pressure release ventilation reduces bronchoalveolar lavage fluid HMGB1 levels and lung water, preserving oxygenation and systemic blood pressure in experimental acute respiratory distress syndrome.