Browse our anti-HMGB1 (HMGB1) Antibodies

Human High-Mobility Group Box 1 (HMGB1) interaction partners

1. This work indicates that NELL-1 (show NELL1 Antibodies), HMGB1, and CCN2 (show CTGF Antibodies) might enhance bone defect healing via the recruitment of endogenous cells and induction of vascularization and act via different processes than BMP2 (show BMP2 Antibodies).

2. comparison of inhibitory potential of the already known inhibitors of Head and neck squamous cell carcinoma against HMGB1-binding pocket using simulations and docking.

3. identified 2 novel miR (show MLXIP Antibodies)-193a-3p targets, the high mobility group box-1 (HMGB1) and the hypoxia upregulated-1 (HYOU1 (show HYOU1 Antibodies)) gene products. HMGB1 silencing in cord blood ECFC-derived cells confirmed its role in regulating vascular function.

4. Results show that HMGB1 is highly expressed in prostate cancer (PC) tissues. Highly expressed HMGB1 activates RAGE (show AGER Antibodies)/NF-kappaB (show NFKB1 Antibodies) signaling pathways, which facilitates the metastasis of prostate cancer.

5. HMGB1 was identified as a down-stream target of miR (show MLXIP Antibodies)-204. The miR (show MLXIP Antibodies)-204/HMGB1 axis mediated ZEB2 (show ZEB2 Antibodies)-AS1's (show ARSB Antibodies) effect on pancreatic cancer.

6. Study demonstrated that HMGB1 and TLR4 (show TLR4 Antibodies) could contribute to the inflammatory lichen planus process in skin.

7. Our research shows that HMGB1 participates in autophagy and DNA damage repair and that downregulation of HMGB1 enhances the sensitivity of multiple myeloma (MM)cells to Dex, suggesting that HMGB1 may serve as a target for MM treatment.

8. HMGB1 plays a critical role in mitochondrial autophagy in cardiomyocytes. miR (show MLXIP Antibodies)-410 targets its 3'UTR (show UTS2R Antibodies) and regulates its transcription.

9. HMGB1 is a good diagnostic biomarker for differentiating refractory M. pneumoniae pneumonia and non-refractory M. pneumoniae pneumonia.

10. HMGB1 promoted lung cancer invasion and metastasis by upregulating the expression and activity of MMP-2 (show MMP2 Antibodies) in an NF-kappaB (show NFKB1 Antibodies)-dependent manner.

Mouse (Murine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. a new pathway for the activation of Treg involving in tumor-derived HMGB1 and TSLP (show TSLP Antibodies), and have important implications for incorporating HMGB1 inhibitors into cancer immunotherapy.

2. HMGB1 plays a novel role in modulating the YAP (show YAP1 Antibodies)-dependent HIF1alpha (show HIF1A Antibodies) pathway and shed light on the development of metabolism-targeting therapeutics for hepatocellular carcinoma chemoprevention

3. In lung tissues of LPS (show TLR4 Antibodies)-endotoxemia, significantly increased levels of SNO (show SBNO2 Antibodies)-SIRT were found. Plasma nitrite and HMGB1 levels were significantly higher than those in the sham controls.

4. Established a murine model of myocardial ischemia-reperfusion injury; investigated and found remote ischemic postconditioning protects against IR injury thru RAGE (show AGER Antibodies)-HMGB1 Pathway.

5. HMGB1 promotes HAdV-7 replication and signals through TLR-4 (show TLR4 Antibodies), TLR-9 (show TLR9 Antibodies), and RAGE (show AGER Antibodies) receptors to activate NF-kappaB (show NFKB1 Antibodies), stimulating the release of inflammatory mediators and contributing to adenoviral pathology.

6. Silencing of Hmgb1 by specific siRNA impeded the induction of 8-Br-cAMP on prolactin (show PRL Antibodies) family 8, subfamily a (show CYP Antibodies), member 2 and Hmgb1 was a critical mediator of Kruppel-like factor 5 (show KLF5 Antibodies) function in stromal differentiation.

7. In the lung, the expression of HMGB1 was greater in diet group and diet mechanical ventilation group than in control group and mechanical ventilation group.

8. these data suggest that HMGB1 may be a checkpoint nuclear factor of macrophage reprogramming

9. using Hmgb1(-/-) mice we identified the underlying mechanism as the transition of multiple quiescent stem cells from G0 to GAlert HMGB1

10. these results suggest that miR1423p functions as a negative regulator of neuropathic pain development through the downregulation of HMGB1, indicating that miR1423p may serve as a potential therapeutic target for neuropathic pain

Cow (Bovine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. HMGB1 can act as an adjuvant in modulating the bovine immune system and thus lays a foundation for using HMGB1 as an adjuvant in various bovine vaccine preparations.

2. Single-nucleotide polymorphism in the 3'-untranslated region of the HMGB1 gene affects the binding of target bta-miR (show MYLIP Antibodies)-223 and is involved in mastitis.

3. The mechanisms of interaction of the non-histone chromosomal protein (show HMGB2 Antibodies) HMGB1 and linker histone H1 (show H1F0 Antibodies) with DNA have been studied using circular dichroism and absorption spectroscopy.

4. HMGB1 is able to induce considerable changes in DNA structure upon binding even when the amount of the protein directly associated with DNA is low

5. Interaction between non-histone chromatin protein HMGB1 and linker histone H1 (show H1F0 Antibodies)

6. HMGB-1 might play a role in the pathological thickening of subchondral bone plate/osteophyte formation.

7. Analysis of mechanical response generated by binding of DNA-bending protein HMGB1 to single tethered 48.5 kb lambda-DNA molecules finds that compaction of DNA increases with increasing HMGB1 concentration.

8. Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin (show F2 Antibodies).

Zebrafish High-Mobility Group Box 1 (HMGB1) interaction partners

1. SCARA5 (show SCARA5 Antibodies) is an HMGB1 recognition receptor that is negatively involved in HMGB1-mediated inflammation in pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio) models.

2. HMGB1 is a critical factor for brain development, enabling survival and proliferation of neural progenitors that will form the forebrain structures.

Pig (Porcine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. Systemic HMGB-1 levels were significantly elevated in both trauma groups when compared to the sham group. Haemorrhagic shock severity and duration were positively correlated with HMGB-1 levels and compared to baseline values, concentrations remained significantly increased in severe hemorrhage when compared to moderate hemorrhage.

2. high levels of HMGB1 in the small intestine and its relation to high levels of HMGB1 in plasma of piglets infected with E. coli O55 that suffered from infection correlated with high levels of inflammatory cytokines and bacterial translocation; levels were higher than HMGB1 levels in piglets with mild clinical symptoms

3. HMGB-1 may participate in the inflammatory response and liver injury in the late stage of acute liver failure

Horse (Equine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. High mobility group box-1 and nucleosomes might have use as biomarkers for horses with gastrointestinal disease.

2. Extracellular HMGB-1 is widespread only in synovial membrane from diseased joints in horses with osteoarthritis.

3. Osteochondral injury was associated with a significant increase in synovial HMGB-1 concentrations in horses with joint injuries, compared with results for clinically normal horses.

Rabbit High-Mobility Group Box 1 (HMGB1) interaction partners

1. Airway pressure release ventilation reduces bronchoalveolar lavage fluid HMGB1 levels and lung water, preserving oxygenation and systemic blood pressure in experimental acute respiratory distress syndrome.