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anti-Human HMGB1 Antibodies:
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Cow (Bovine) Polyclonal HMGB1 Primary Antibody for ELISA, FACS - ABIN250703
Barlan, Griffin, McGuire, Wiethoff: Adenovirus membrane penetration activates the NLRP3 inflammasome. in Journal of virology 2010
Show all 13 Pubmed References
Human Monoclonal HMGB1 Primary Antibody for CyTOF, FACS - ABIN4899428
Liou, Adler, Keogh, Li, Jensen, Walsh, Packer, Clark, Carveth, Chen, Rogers, Lane, Moore, Sturrock, Paine, Cox, Hoidal: Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosis. in PLoS ONE 2012
Show all 13 Pubmed References
Human Monoclonal HMGB1 Primary Antibody for CyTOF, FACS - ABIN4899429
Davé, Tilstra, Matsuoka, Li, DeMarco, Beer-Stolz, Sepulveda, Fink, Lotze, Plevy: Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis. in Journal of leukocyte biology 2009
Show all 13 Pubmed References
Human Polyclonal HMGB1 Primary Antibody for IF (p), IHC (p) - ABIN671616
Zhao, Hu, Sun, Sun: The high mobility group box 1 protein of Sciaenops ocellatus is a secreted cytokine that stimulates macrophage activation. in Developmental and comparative immunology 2011
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Human Monoclonal HMGB1 Primary Antibody for IF, IHC (p) - ABIN561281
Krüger, Krick, Dhillon, Lerner, Ames, Bromberg, Lin, Walsh, Vella, Fischereder, Krämer, Colvin, Heeger, Murphy, Schröppel: Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation. in Proceedings of the National Academy of Sciences of the United States of America 2009
Show all 5 Pubmed References
Human Monoclonal HMGB1 Primary Antibody for IF, IHC (p) - ABIN561282
Franciosi, Govorukhina, Fusetti, Poolman, Lodewijk, Timens, Postma, ten Hacken, Bischoff: Proteomic analysis of human epithelial lining fluid by microfluidics-based nanoLC-MS/MS: a feasibility study. in Electrophoresis 2013
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Human Monoclonal HMGB1 Primary Antibody for IF, IHC (p) - ABIN561286
Zhou, Huang, Poon, Chen, Chan, Ng, Guan, Watt, Lu, Yuen, Zheng: Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection. in Journal of hepatology 2009
Show all 2 Pubmed References
Human Monoclonal HMGB1 Primary Antibody for IF, IHC (p) - ABIN1326935
Kim, Ku, Bae: Persicarin is anti-inflammatory mediator against HMGB1-induced inflammatory responses in HUVECs and in CLP-induced sepsis mice. in Journal of cellular physiology 2013
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Hamster Monoclonal HMGB1 Primary Antibody for FACS, IF - ABIN2474000
Lange, Vasquez: HMGB1: the jack-of-all-trades protein is a master DNA repair mechanic. in Molecular carcinogenesis 2009
Cow (Bovine) Polyclonal HMGB1 Primary Antibody for WB - ABIN2780399
Straino, Di Carlo, Mangoni, De Mori, Guerra, Maurelli, Panacchia, Di Giacomo, Palumbo, Di Campli, Uccioli, Biglioli, Bianchi, Capogrossi, Germani: High-mobility group box 1 protein in human and murine skin: involvement in wound healing. in The Journal of investigative dermatology 2008
High mobility group box 1 (HMGB1) has been proposed as biomarker potentially able to elucidate the causative relationship between the immune system and gut (show GUSB Antibodies) mucosal inflammation and onset and progression of gastrointestinal diseases.
Data revealed an increased risk of oral squamous cell carcinoma (OSCC) among patients with the HMGB1 polymorphism rs1045411 C/C compared with those with the C/T or C/T+T/T genotype and confirms the association of rs1045411 in the HMGB1 3'-UTR (show UTS2R Antibodies) region with OSCC risk most likely because a putative miRNA-505 binding site.
These findings demonstrate that released HMGB1 is central to DS, and that targeting HMGB1 may be of therapeutic value in the treatment of DS.
HMGB1 overexpression is associated with poorer prognosis in patients with various types of cancer, suggesting that it is a prognostic factor and potential biomarker for survival in cancer [review and meta-analysis]
High-Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells.
Hmgb1 can inhibit Klotho (show KL Antibodies) gene expression and malignant phenotype in melanoma cells through activation of NF-kappaB (show NFKB1 Antibodies) signaling.
Further exploration of molecular mechanisms underlying the function of HMGB1 in lung diseases will provide novel preventive and therapeutic strategies for lung diseases.
Data show that HMGB1 is a direct target of miR (show MLXIP Antibodies)-142 in cervical cancer and it is implicated in miR (show MLXIP Antibodies)-142-induced cell proliferation, invasiveness and apoptosis of cervical cancer cells.
In addition to the findings that HMGB1 is a sensitive biomarker of allergic asthma in children, data demonstrated a significant correlation between the decrease of HMGB1 levels and a successful treatment response.
miR (show MLXIP Antibodies)-193a displayed its role in lung cancer via modulating the HMGB1 expression. This study demonstrated that UCA1 exerts oncogenes activity in lung cancer, acting mechanistically by upregulating HMGB1 expression through 'sponging' miR (show MLXIP Antibodies)-193a.
Here, the authors show that RAGE (show AGER Antibodies) deficiency impairs anti-viral immunity during an early-life infection with pneumonia virus of mice (PVM; a murine analogue of RSV). The elevated viral load was associated with the release of high mobility group box-1 (HMGB1) which triggered airway smooth muscle remodelling in early-life.
HMGB1 is expressed and secreted from intestinal epithelial cells in response to Wnt (show WNT2 Antibodies) signalling activation. This secreted HMGB1 is required to maintain nearly all aspects of the crypt progenitor phenotype observed following Apc (show APC Antibodies) loss and add to the body of accumulating evidence indicating that targeting HMGB1 may be a viable novel therapeutic approach.
Our data suggest that, apart from the role of D3, TMalpha and TM's D123 (show CDC123 Antibodies) require both lectin-like D1 capable of sequestering HMGB1 and EGF (show EGF Antibodies)-like D2 responsible for thrombin (show F2 Antibodies)-dependent degradation of HMGB1, in abolishing the allodynia caused by exogenous or endogenous HMGB1.
Anti-HMGB1 autoimmunity may potentially play a role in atherogenesis in Apoe (show APOE Antibodies)(-/-) mice
These results suggest that HMGB1-modulated TLR5 (show TLR5 Antibodies) signaling is responsible for pain hypersensitivity.
mip-2 (show CXCL2 Antibodies) siRNA and an anti-MIP-2 (show CXCL2 Antibodies) antibody significantly reduced the expression levels of Ccl-2 (show CCL2 Antibodies), TLR-4 (show TLR4 Antibodies), iNOS (show NOS2 Antibodies), IL-6 (show IL6 Antibodies), IL-1beta (show IL1B Antibodies), HMGB1, and TNF-alpha (show TNF Antibodies) in RAW264.7 cells exposed tolipopolysaccharide.
We concluded that fusion of HMGB1 with GFP was immunologically more effective than GFP alone.
HMGB-1 is a late inflammatory mediator of sepsis.
HMGB1 activates the NF-kappaB (show NFKB1 Antibodies) and JNK (show MAPK8 Antibodies)/p38 (show CRK Antibodies) pathways through TLR4 (show TLR4 Antibodies)/MyD88 (show MYD88 Antibodies)-dependent signaling and induces an inflammatory response in lungs exposed to cigarette smoke.
Data demonstrate that inhibition of HMGB1 reduced inflammatory mediators, leading to increased insulin receptor (show INSR Antibodies) signal transduction in retinal endothelial cells grown in high glucose. Secondly, use of glycyrrhizin was an effective therapy against ischemia-reperfusion-induced retinal neuronal and vascular damage.
HMGB1 can act as an adjuvant in modulating the bovine immune system and thus lays a foundation for using HMGB1 as an adjuvant in various bovine vaccine preparations.
Single-nucleotide polymorphism in the 3'-untranslated region of the HMGB1 gene affects the binding of target bta-miR (show MYLIP Antibodies)-223 and is involved in mastitis.
The mechanisms of interaction of the non-histone chromosomal protein (show HMGB2 Antibodies) HMGB1 and linker histone H1 (show H1F0 Antibodies) with DNA have been studied using circular dichroism and absorption spectroscopy.
HMGB1 is able to induce considerable changes in DNA structure upon binding even when the amount of the protein directly associated with DNA is low
Interaction between non-histone chromatin protein HMGB1 and linker histone H1 (show H1F0 Antibodies)
HMGB-1 might play a role in the pathological thickening of subchondral bone plate/osteophyte formation.
Analysis of mechanical response generated by binding of DNA-bending protein HMGB1 to single tethered 48.5 kb lambda-DNA molecules finds that compaction of DNA increases with increasing HMGB1 concentration.
Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin (show F2 Antibodies).
SCARA5 (show SCARA5 Antibodies) is an HMGB1 recognition receptor that is negatively involved in HMGB1-mediated inflammation in pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio) models.
HMGB1 is a critical factor for brain development, enabling survival and proliferation of neural progenitors that will form the forebrain structures.
Systemic HMGB-1 levels were significantly elevated in both trauma groups when compared to the sham group. Haemorrhagic shock severity and duration were positively correlated with HMGB-1 levels and compared to baseline values, concentrations remained significantly increased in severe hemorrhage when compared to moderate hemorrhage.
high levels of HMGB1 in the small intestine and its relation to high levels of HMGB1 in plasma of piglets infected with E. coli O55 that suffered from infection correlated with high levels of inflammatory cytokines and bacterial translocation; levels were higher than HMGB1 levels in piglets with mild clinical symptoms
HMGB-1 may participate in the inflammatory response and liver injury in the late stage of acute liver failure
High mobility group box-1 and nucleosomes might have use as biomarkers for horses with gastrointestinal disease.
Extracellular HMGB-1 is widespread only in synovial membrane from diseased joints in horses with osteoarthritis.
Osteochondral injury was associated with a significant increase in synovial HMGB-1 concentrations in horses with joint injuries, compared with results for clinically normal horses.
Airway pressure release ventilation reduces bronchoalveolar lavage fluid HMGB1 levels and lung water, preserving oxygenation and systemic blood pressure in experimental acute respiratory distress syndrome.
heparin binding protein that facilitates neurite outgrowth
, Sulfoglucuronyl carbohydrate binding protein
, high mobility group protein 1
, high mobility group protein B1
, high-mobility group (nonhistone chromosomal) protein 1
, high-mobility group box 1
, sulfoglucuronyl carbohydrate binding protein
, high mobility group box 1
, high mobility group 1 protein
, high mobility group protein HMG1
, non-histone protein HMG1
, high mobility group protein B1-like protein
, High mobility group protein B1
, high mobility group protein B1-like
, High mobility group protein 1
, heparin-binding protein p30
, high mobility group 1