Browse our anti-HMGB1 (HMGB1) Antibodies

Human High-Mobility Group Box 1 (HMGB1) interaction partners

1. These findings indicated that HMGB1 likely regulates autophagy in LO2 cells exposed to anoxia-reoxygenation injury

2. extracellular functions of HMGB1 in cellular and immune homeostasis at the airway mucosal surface

3. Our results indicate that genetic variations in the HMGB1 gene may serve as an important predictor of breast cancer progression and metastasis.

4. soluble CD52 exerts a concerted immunosuppressive effect by first sequestering HMGB1 to nullify its proinflammatory Box B, followed by binding to the inhibitory Siglec-10 receptor, triggering recruitment of SHP1 to the intracellular immunoreceptor tyrosine-based inhibitory motif of Siglec-10 and its interaction with the TCR.

5. In lung cancer patients, circulating HMGB1-containing nucleosome is higher in those under chemotherapy, predicting poorly cancer cell differentiation state, enhanced cancer invasion and advanced TNM (show ODZ1 Antibodies) stages.

6. a number of microRNAs (miRNAs) are identified as a class of regulators for broad control of HMGB1-mediated biological actions in eukaryotic cells.

7. The study indicated polymorphisms in HMGB1 may be a novel biomarker for female lung adenocarcinoma risk.

8. Glycyrrhizin reduced the activity of JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) signaling pathway, which is the upstream regulator of HMGB1.

9. HMGB1 may be a useful prognostic biomarker in malignant pleural mesothelioma when detected by immunohistochemistry, but cannot be considered a diagnostic biomarker in histological samples of mesothelioma

10. the present study indicates that PBX 3'UTR (show UTS2R Antibodies) may induce inflammatory responses and sepsis via acting as a competing endogenous RNA for HMGB1.

Mouse (Murine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. Silencing of Hmgb1 by specific siRNA impeded the induction of 8-Br-cAMP on prolactin (show PRL Antibodies) family 8, subfamily a (show CYP Antibodies), member 2 and Hmgb1 was a critical mediator of Kruppel-like factor 5 (show KLF5 Antibodies) function in stromal differentiation.

2. In the lung, the expression of HMGB1 was greater in diet group and diet mechanical ventilation group than in control group and mechanical ventilation group.

3. these data suggest that HMGB1 may be a checkpoint nuclear factor of macrophage reprogramming

4. using Hmgb1(-/-) mice we identified the underlying mechanism as the transition of multiple quiescent stem cells from G0 to GAlert HMGB1

5. these results suggest that miR1423p functions as a negative regulator of neuropathic pain development through the downregulation of HMGB1, indicating that miR1423p may serve as a potential therapeutic target for neuropathic pain

6. Chronic unpredictable stress (CUS) promotes significant morphological changes and causes robust upregulation of HMGB1 messenger RNA in enriched hippocampal microglia and robust and persistent upregulation of RAGE (show AGER Antibodies) messenger RNA. CUS increased surface expression of RAGE (show AGER Antibodies) protein on hippocampal microglia and anhedonic behavior. HMGB1 infusion into the hippocampus was sufficient to cause anhedonic behavior.

7. HMGB1/IL-1beta (show IL1B Antibodies) complexes released after burn injuries can modulate immune responses

8. hypoxia affects tumour growth and metastasis in melanoma and depict HMGB1 as a potential therapeutic target.

9. Chloroquine improves the response to ischemic muscle injury and increases HMGB1 after arterial ligation.

10. Data suggest high mobility group box 1 (HMGB1) expression may be associated with the protective effect of saquinavir (SQV).

Cow (Bovine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. HMGB1 can act as an adjuvant in modulating the bovine immune system and thus lays a foundation for using HMGB1 as an adjuvant in various bovine vaccine preparations.

2. Single-nucleotide polymorphism in the 3'-untranslated region of the HMGB1 gene affects the binding of target bta-miR (show MYLIP Antibodies)-223 and is involved in mastitis.

3. The mechanisms of interaction of the non-histone chromosomal protein (show HMGB2 Antibodies) HMGB1 and linker histone H1 (show H1F0 Antibodies) with DNA have been studied using circular dichroism and absorption spectroscopy.

4. HMGB1 is able to induce considerable changes in DNA structure upon binding even when the amount of the protein directly associated with DNA is low

5. Interaction between non-histone chromatin protein HMGB1 and linker histone H1 (show H1F0 Antibodies)

6. HMGB-1 might play a role in the pathological thickening of subchondral bone plate/osteophyte formation.

7. Analysis of mechanical response generated by binding of DNA-bending protein HMGB1 to single tethered 48.5 kb lambda-DNA molecules finds that compaction of DNA increases with increasing HMGB1 concentration.

8. Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin (show F2 Antibodies).

Zebrafish High-Mobility Group Box 1 (HMGB1) interaction partners

1. SCARA5 (show SCARA5 Antibodies) is an HMGB1 recognition receptor that is negatively involved in HMGB1-mediated inflammation in pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio) models.

2. HMGB1 is a critical factor for brain development, enabling survival and proliferation of neural progenitors that will form the forebrain structures.

Pig (Porcine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. Systemic HMGB-1 levels were significantly elevated in both trauma groups when compared to the sham group. Haemorrhagic shock severity and duration were positively correlated with HMGB-1 levels and compared to baseline values, concentrations remained significantly increased in severe hemorrhage when compared to moderate hemorrhage.

2. high levels of HMGB1 in the small intestine and its relation to high levels of HMGB1 in plasma of piglets infected with E. coli O55 that suffered from infection correlated with high levels of inflammatory cytokines and bacterial translocation; levels were higher than HMGB1 levels in piglets with mild clinical symptoms

3. HMGB-1 may participate in the inflammatory response and liver injury in the late stage of acute liver failure

Horse (Equine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. High mobility group box-1 and nucleosomes might have use as biomarkers for horses with gastrointestinal disease.

2. Extracellular HMGB-1 is widespread only in synovial membrane from diseased joints in horses with osteoarthritis.

3. Osteochondral injury was associated with a significant increase in synovial HMGB-1 concentrations in horses with joint injuries, compared with results for clinically normal horses.

Rabbit High-Mobility Group Box 1 (HMGB1) interaction partners

1. Airway pressure release ventilation reduces bronchoalveolar lavage fluid HMGB1 levels and lung water, preserving oxygenation and systemic blood pressure in experimental acute respiratory distress syndrome.