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anti-Human HMGB1 Antibodies:
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Cow (Bovine) Polyclonal HMGB1 Primary Antibody for ELISA, FACS - ABIN250703
Barlan, Griffin, McGuire, Wiethoff: Adenovirus membrane penetration activates the NLRP3 inflammasome. in Journal of virology 2010
Show all 17 Pubmed References
Human Monoclonal HMGB1 Primary Antibody for CyTOF, FACS - ABIN4899428
Liou, Adler, Keogh, Li, Jensen, Walsh, Packer, Clark, Carveth, Chen, Rogers, Lane, Moore, Sturrock, Paine, Cox, Hoidal: Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosis. in PLoS ONE 2012
Show all 13 Pubmed References
Human Polyclonal HMGB1 Primary Antibody for IF (p), IHC (p) - ABIN671616
Zhao, Hu, Sun, Sun: The high mobility group box 1 protein of Sciaenops ocellatus is a secreted cytokine that stimulates macrophage activation. in Developmental and comparative immunology 2011
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Human Monoclonal HMGB1 Primary Antibody for IF, IHC (p) - ABIN561281
Krüger, Krick, Dhillon, Lerner, Ames, Bromberg, Lin, Walsh, Vella, Fischereder, Krämer, Colvin, Heeger, Murphy, Schröppel: Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation. in Proceedings of the National Academy of Sciences of the United States of America 2009
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Human Polyclonal HMGB1 Primary Antibody for ELISA, ICC - ABIN6269456
Wang, Sun, Li, Deng, Zeng, Tao, Wang, Guan, Zhao: Urinary MCP-1、HMGB1 increased in calcium nephrolithiasis patients and the influence of hypercalciuria on the production of the two cytokines. in Urolithiasis 2016
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Human Polyclonal HMGB1 Primary Antibody for IHC (p), WB - ABIN5518759
Bi, Zhu, Yan, Chen, Wang, Ma, Yang: Association of Upregulated HMGB1 and c-IAP2 Proteins With Hepatocellular Carcinoma Development and Progression. in Hepatitis monthly 2015
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Human Polyclonal HMGB1 Primary Antibody for IHC, WB - ABIN3023358
Yao, Zhao, Tang, Xiong, Zhao, Liu, Dong, Zou, Cai: Blockade of β-catenin signaling attenuates toluene diisocyanate-induced experimental asthma. in Allergy 2017
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Human Polyclonal HMGB1 Primary Antibody for IHC, WB - ABIN6673672
Chen, Yu, Yuan, Zhang, Fan, Yuan, Zhang, Yao: Enriched housing promotes post-stroke functional recovery through astrocytic HMGB1-IL-6-mediated angiogenesis. in Cell death discovery 2017
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Human Monoclonal HMGB1 Primary Antibody for IF, IHC (p) - ABIN561282
Franciosi, Govorukhina, Fusetti, Poolman, Lodewijk, Timens, Postma, ten Hacken, Bischoff: Proteomic analysis of human epithelial lining fluid by microfluidics-based nanoLC-MS/MS: a feasibility study. in Electrophoresis 2013
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Human Monoclonal HMGB1 Primary Antibody for IF, IHC (p) - ABIN561286
Zhou, Huang, Poon, Chen, Chan, Ng, Guan, Watt, Lu, Yuen, Zheng: Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection. in Journal of hepatology 2009
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high sputum HMGB1 was not associated with severe disease, but with pneumococcal bacteraemia, indicating a potential role for HMGB1 in bacterial dissemination. High sputum lytA was associated with severe disease.
damage-associated molecular pattern molecule that promotes inflammation in nucleus pulposus (NP) cells and degradation of NP tissues
melanocytes expressing small hairpin RNA selective for the HMGB1 receptor, receptor for advanced glycosylation end product (RAGE), exhibited decreased expression of both HMGB1 and MX1 after UVB exposure
These data demonstrated that external stimuli (eg, oxidative stress) may trigger autocrine HMGB1 translocation and release by melanocytes, suppressing the expression of Nrf2 and downstream antioxidant genes to induce melanocyte apoptosis, and thereby participate in the pathological process of vitiligo.
this study shows that excess glucose induce trophoblast inflammation and limit cell migration through HMGB1 activation of Toll-Like receptor 4
MALAT1 may aggravate hepatic I/R injury by regulating the HMGB1-TLR4-triggered cell apoptosis.
miR-1179/HMGB1 axis plays a role in the progression of gastric cancer.
Profibrogenic effect of high-mobility group box protein-1 in human dermal fibroblasts and its excess in keloid tissues
The extracellular HMGB1 induced the migration of PMBC-derived macrophages toward HUVECs in a TLR4-dependent manner. Our results suggested that ox-LDL promoted HUVECs apoptosis and macrophage recruitment by regulating caveolin-1 phosphorylation.
This study, for the first time, reports that miR-142-3p is a novel tumor suppressor that inhibits the invasion and migration of Hepatocellular Carcinoma Cells cells by directly regulating gene transcription of HMGB1.
Study demonstrates a role for the high mobility group box 1 - toll-like receptor 4 pathway at the syncytium layer and suggests involvement in placental inflammation and preeclampsia
MALAT1/miR-129-5p/HMGB1 axis could be provided as an important prognostic biomarker in colon cancer development.
HMGB1 links hepatocyte death to ductular reaction, progenitor signature, and hepatocarcinogenesis in chronic liver disease.
we observed major alterations in the HMGB1-TLR4 signaling axis. Functional analysis also showed that HMGB1 expression is important for the proliferative and tumorigenic potential of cervical cancer cell lines.
these results shows that high HMGB1 levels induced by a reduced hydration status play an important role in hypertrophic scar formation
High HMGB1 and low Hsp70 were associated with poor prognosis in patients with acute pancreatitis. Hsp70 might play a protective role in acute pancreatitis.
ICM inhibited autophagy by inhibiting nucleocytoplasmic translocation of HMGB1 and by increasing Beclin 1 ubiquitylation for degradation by enhancing the interaction between Beclin 1 and E3 ubiquitin ligase RNF216
High HMGB1 expression is associated with urothelial carcinoma of the bladder.
Data show the autophagy-inducing effects by high-mobility group box-1 (HMGB1) in both primary murine hepatic stellate cells (HSCs) and human HSCs cell line (LX-2).
These results demonstrate the general phenomenon that Rh-endostatin can induce HMGB1 suppression in a variety of non-small cell lung cancer cells. Rh-endostatin may suppress HMGB1 expression and release in A549 cancer cells, thus inhibiting cell proliferation.
Results provide a novel evidence that HMGB1 play a critical role in ANG II mediated macrophage polarization, and we suggest that ANG II mediated HMGB1 release via dissociation from SIRT1.
HMGB1 expression in serous exosomes was elevated in ASC-/- high-fat diet (HFD) -fed mice. HMGB1 was highly expressed in the intestines of the ASC-/- HFD-fed mice. Hepatic steatosis, and intestinal mucosal damage, and dysbiosis aggravates in HFD mice, especially in ASC-/- mice.
Strategies to block the interaction between HMGB1 and its receptors may be effective in preventing the development of DN.
The NLRP3 inflammasome is upregulated in activated astrocytes. HMGB1 could effectively promote NLRP3 inflammasome formation in astrocytes, by activating NF-kappaB. IL4 could inhibit NLRP3 inflammasome formation, through negative regulation NF-kappaB and promotion PPARgamma activation.
A novel RAG1 mutation reveals a critical in vivo role for HMGB1/2 during V(D)J recombination.
our present study has revealed pivotal effect of HMGB1 on NSCs migration and its possible underlying mechanism in vitro, which is a significant supplement of HMGB1 on NSCs activation.
results indicate that Partial Sciatic Nerve Ligation-induced anxiodepressive-like behavior is likely mediated by HMGB1.
Radiation could activate MAPK signaling pathway through promoting the expression of HMGB1 and RAGE.
HMGB1 reduced the expression of tight junctions between endothelial cells, including VE-cadherin and ZO-1, and increased endothelial permeability, and both were blocked by propofol. We found that MLVECs exhibited mitochondrial oxidative damage by HMGB1.
HMGB1 release is a critical mechanism in hepatic pathogenesis under autophagy-deficient conditions and leads to hepatic progenitor cells expansion as well as tumor progression.
Taken together, the authors identified miR-181a-5p a negative regulator in HMGB1-induced immune responses by targeting TNF-alpha mRNA in dendritic cells.
Epac1 deacetylates HMGB1 through increased IGFBP-3 and SIRT1 levels in the retinal vasculature.
TGF-beta1 is a vital regulatory factor in denervated skeletal muscle in which HMGB1/ autophagy pathway mediates the atrophic effect of TGF-beta1
Findings indicate that high mobility group box 1 (HMGB1) interacts with lipopolysaccharide (LPS) to mediate caspase-11-dependent pyroptosis in lethal sepsis.
The data of this study showed that spinal HMGB1 was increased by ischemic stroke, and spinal HMGB1 colocalized with neurons but not microglia and astrocytes.
this study shows GSTP prevents sepsis-related HMGB1 Protein translocation and release
results indicate that HMGB1 may be an important contributor in the prevention and treatment of pneumonia of carbapenem-resistant-induced pneumonia
HMGB1 promotes lipopolysaccharide-induced peritoneal mesothelial cells apoptosis, which is associated with JNK1-mediated upregulation of HMGB1 acetylation.
HMGB1 can act as an adjuvant in modulating the bovine immune system and thus lays a foundation for using HMGB1 as an adjuvant in various bovine vaccine preparations.
Single-nucleotide polymorphism in the 3'-untranslated region of the HMGB1 gene affects the binding of target bta-miR-223 and is involved in mastitis.
The mechanisms of interaction of the non-histone chromosomal protein HMGB1 and linker histone H1 with DNA have been studied using circular dichroism and absorption spectroscopy.
HMGB1 is able to induce considerable changes in DNA structure upon binding even when the amount of the protein directly associated with DNA is low
Interaction between non-histone chromatin protein HMGB1 and linker histone H1
HMGB-1 might play a role in the pathological thickening of subchondral bone plate/osteophyte formation.
Analysis of mechanical response generated by binding of DNA-bending protein HMGB1 to single tethered 48.5 kb lambda-DNA molecules finds that compaction of DNA increases with increasing HMGB1 concentration.
Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin.
SCARA5 is an HMGB1 recognition receptor that is negatively involved in HMGB1-mediated inflammation in pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio) models.
HMGB1 is a critical factor for brain development, enabling survival and proliferation of neural progenitors that will form the forebrain structures.
Systemic HMGB-1 levels were significantly elevated in both trauma groups when compared to the sham group. Haemorrhagic shock severity and duration were positively correlated with HMGB-1 levels and compared to baseline values, concentrations remained significantly increased in severe hemorrhage when compared to moderate hemorrhage.
high levels of HMGB1 in the small intestine and its relation to high levels of HMGB1 in plasma of piglets infected with E. coli O55 that suffered from infection correlated with high levels of inflammatory cytokines and bacterial translocation; levels were higher than HMGB1 levels in piglets with mild clinical symptoms
HMGB-1 may participate in the inflammatory response and liver injury in the late stage of acute liver failure
High mobility group box-1 and nucleosomes might have use as biomarkers for horses with gastrointestinal disease.
Extracellular HMGB-1 is widespread only in synovial membrane from diseased joints in horses with osteoarthritis.
Osteochondral injury was associated with a significant increase in synovial HMGB-1 concentrations in horses with joint injuries, compared with results for clinically normal horses.
Airway pressure release ventilation reduces bronchoalveolar lavage fluid HMGB1 levels and lung water, preserving oxygenation and systemic blood pressure in experimental acute respiratory distress syndrome.
heparin binding protein that facilitates neurite outgrowth
, Sulfoglucuronyl carbohydrate binding protein
, high mobility group protein 1
, high mobility group protein B1
, high-mobility group (nonhistone chromosomal) protein 1
, high-mobility group box 1
, sulfoglucuronyl carbohydrate binding protein
, high mobility group box 1
, high mobility group 1 protein
, high mobility group protein HMG1
, non-histone protein HMG1
, high mobility group protein B1-like protein
, High mobility group protein B1
, high mobility group protein B1-like
, High mobility group protein 1
, heparin-binding protein p30
, high mobility group 1