Browse our anti-HMGB1 (HMGB1) Antibodies

Human High-Mobility Group Box 1 (HMGB1) interaction partners

1. Study revealed that HMGB1 acts as a mediator of neurite degeneration through the identification of the pathological signaling pathway in Alzheimer's disease (AD). The signaling pathway is initiated with the extracellular release of HMGB1, followed by activation of the TLR4-MAP kinases, phosphorylation of MARCKS at Ser46, and neurite degeneration via instability of the actin network.

2. In type 2 diabetes patients HMGB-1 and OPG (show TNFRSF11B Antibodies) serum levels are higher in patients affected by peripheral arterial disease and independently associated with its occurrence and clinical severity

3. The levels of plasma HMGB1 were significantly elevated in communityacquired pneumoni (show JUN Antibodies)a patients compared wi (show MAPK8 Antibodies)th the controls, and antibiotic treatment was effective in reducing HMGB1 levels. Plasma HMGB1 correlated with the pneumonia severity index score (r=0.566, P<0.001).

4. this study shows that intracellular high mobility group box 1 (HMGB1) remarkably suppresses oncogenic K-Ras (show HRAS Antibodies)-driven pancreatic tumorigenesis by inhibiting chromosome instability-mediated pro-inflammatory nucleosome release.

5. HMGB1 signaling pathways may be more easily activated in elderly coronary artery disease patients with concomitant inflammatory rheumatic disease and trigger a detrimental inflammatory process causing severe cardiovascular problems.

6. In-depth IPA analysis revealed that CENPU (show MLF1IP Antibodies) was associated with the HMGB1 signaling pathway. qPCR and western blot analysis demonstrated that in the HMGB1 signaling pathway, CENPU (show MLF1IP Antibodies) knockdown downregulated expression levels of ILB, CXCL8 (show IL8 Antibodies), RAC1 and IL1A (show IL1A Antibodies)

7. HMGB1 may be a necessary intermediate in the ceramide-dependent metabolic consequences of cigarette smoke exposure.

8. HMGB1 amplified neutrophil activation and the activation and injury of glomerular endothelial cells in the presence of antineutrophil cytoplasmic antibody .

9. HMGB1 is over-expressed in chronic middle-ear pathologies and may play a role in the progression of the inflammatory process from recurrent acute otitis media to chronic suppurative otitis media.

10. High mobility group box 1 (HMGB1) has been proposed as biomarker potentially able to elucidate the causative relationship between the immune system and gut (show GUSB Antibodies) mucosal inflammation and onset and progression of gastrointestinal diseases.

Mouse (Murine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. The injury resistance in the setting of liver fibrosis is accompanied by the inhibition of HMGB1 translocation and release as well as the suppression of HMGB1-related proinflammatory immune responses.

2. These data demonstrate that 2% H2 inhalation may be a promising therapeutic strategy for intestinal injuries caused by severe sepsis through the regulation of HO-1 (show HMOX1 Antibodies) and HMGB1 release. In addition, Nrf2 (show NFE2L2 Antibodies) plays a key role in the protective effects of H2 against intestinal damage in this disease.

3. Lipopolysaccharidestimulation significantly upregulated HMGB1 secretion via the cJun (show JUN Antibodies) Nterminal kinase (JNK (show MAPK8 Antibodies)) signaling pathway in RAW264.7 macrophages.

4. HMGB1 oxidation increases during sepsis and enhances HMGB1's pro-inflammatory signaling.

5. HMGB1/TLR2 activates an autocrine trophic signaling pathways in OLs.

6. It is possible that JNK (show MAPK8 Antibodies) and TNF-alpha (show TNF Antibodies) commonly contribute to kidney damage by assembling a positive feedback cycle after crush syndrome, leading to increased apoptosis in the renal cortex. HMGB1 from the muscle may be the trigger.

7. Here, we show that cabozantinib rapidly eradicates invasive, poorly differentiated PTEN/p53 (show TP53 Antibodies)-deficient murine prostate cancer. This was associated with enhanced release of neutrophil chemotactic factors from tumor cells, including CXCL12 (show CXCL12 Antibodies) and HMGB1, resulting in robust infiltration of neutrophils into the tumor.

8. OVA-induced allergic lung inflammation altered redox status concomitantly with impaired lung function, which was associated with HMGB1 expression and proteolytic remodeling.

9. Here, the authors show that RAGE (show AGER Antibodies) deficiency impairs anti-viral immunity during an early-life infection with pneumonia virus of mice (PVM; a murine analogue of RSV). The elevated viral load was associated with the release of high mobility group box-1 (HMGB1) which triggered airway smooth muscle remodelling in early-life.

10. HMGB1 is expressed and secreted from intestinal epithelial cells in response to Wnt (show WNT2 Antibodies) signalling activation. This secreted HMGB1 is required to maintain nearly all aspects of the crypt progenitor phenotype observed following Apc (show APC Antibodies) loss and add to the body of accumulating evidence indicating that targeting HMGB1 may be a viable novel therapeutic approach.

Cow (Bovine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. HMGB1 can act as an adjuvant in modulating the bovine immune system and thus lays a foundation for using HMGB1 as an adjuvant in various bovine vaccine preparations.

2. Single-nucleotide polymorphism in the 3'-untranslated region of the HMGB1 gene affects the binding of target bta-miR (show MYLIP Antibodies)-223 and is involved in mastitis.

3. The mechanisms of interaction of the non-histone chromosomal protein (show HMGB2 Antibodies) HMGB1 and linker histone H1 (show H1F0 Antibodies) with DNA have been studied using circular dichroism and absorption spectroscopy.

4. HMGB1 is able to induce considerable changes in DNA structure upon binding even when the amount of the protein directly associated with DNA is low

5. Interaction between non-histone chromatin protein HMGB1 and linker histone H1 (show H1F0 Antibodies)

6. HMGB-1 might play a role in the pathological thickening of subchondral bone plate/osteophyte formation.

7. Analysis of mechanical response generated by binding of DNA-bending protein HMGB1 to single tethered 48.5 kb lambda-DNA molecules finds that compaction of DNA increases with increasing HMGB1 concentration.

8. Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin (show F2 Antibodies).

Zebrafish High-Mobility Group Box 1 (HMGB1) interaction partners

1. SCARA5 (show SCARA5 Antibodies) is an HMGB1 recognition receptor that is negatively involved in HMGB1-mediated inflammation in pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio) models.

2. HMGB1 is a critical factor for brain development, enabling survival and proliferation of neural progenitors that will form the forebrain structures.

Pig (Porcine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. Systemic HMGB-1 levels were significantly elevated in both trauma groups when compared to the sham group. Haemorrhagic shock severity and duration were positively correlated with HMGB-1 levels and compared to baseline values, concentrations remained significantly increased in severe hemorrhage when compared to moderate hemorrhage.

2. high levels of HMGB1 in the small intestine and its relation to high levels of HMGB1 in plasma of piglets infected with E. coli O55 that suffered from infection correlated with high levels of inflammatory cytokines and bacterial translocation; levels were higher than HMGB1 levels in piglets with mild clinical symptoms

3. HMGB-1 may participate in the inflammatory response and liver injury in the late stage of acute liver failure

Horse (Equine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. High mobility group box-1 and nucleosomes might have use as biomarkers for horses with gastrointestinal disease.

2. Extracellular HMGB-1 is widespread only in synovial membrane from diseased joints in horses with osteoarthritis.

3. Osteochondral injury was associated with a significant increase in synovial HMGB-1 concentrations in horses with joint injuries, compared with results for clinically normal horses.

Rabbit High-Mobility Group Box 1 (HMGB1) interaction partners

1. Airway pressure release ventilation reduces bronchoalveolar lavage fluid HMGB1 levels and lung water, preserving oxygenation and systemic blood pressure in experimental acute respiratory distress syndrome.