Browse our anti-HMGB1 (HMGB1) Antibodies

Human High-Mobility Group Box 1 (HMGB1) interaction partners

1. hypoxia exposure gave rise to HMGB1 expression in hepatoma cells of human and mouse in a HIF-1alpha-dependent manner and subsequently induced the infiltration and reprogramming of macrophages to augment the expression of Il-6.

2. The overexpression of miR-1284 inhibited the cell proliferation and migration, and altered the protein expression of epithelial-mesenchymal transition (EMT)-associated genes (E-cadherin, N-cadherin, Vimentin, and Snail), which was reversed by HMGB1 overexpression. In conclusion, miR-1284 can function as a new regulator to inhibit osteosarcoma cell proliferation and migration by targeting HMGB1.

3. Study reports for the first-time correlation of HMGB1 polymorphisms with urothelial cell carcinoma (UCC) risk. Carrying at least one T allele at rs1045411 is associated with a lower risk of UCC and a less invasive disease in women and nonsmokers.

4. Particulate matter 2.5 induces the expression of TGF-beta1, PDGF-AB, and PDGF-BB in vitro via HMGB1-RAGE signaling, suggesting that this pathway may contribute to the airway remodeling observed in patients with chronic obstructive pulmonary disease.

5. The HMGB1-TLR4 pathway was up-regulated in the neurons and astrocytes inside focal cortical dysplasia type II brain lesions.

6. HMGB1 blocker glycyrrhizin can inhibit activation of the TLR4/NF-kappaB signaling pathway and the secretion of inflammatory factors

7. Findings indicate that high mobility group box 1 (HMGB1) interacts with lipopolysaccharide (LPS) to mediate caspase-11-dependent pyroptosis in lethal sepsis.

8. Results show that plasma HMGB-1 concentrations were significantly increased in silicosis patients when compared with healthy controls. Elevated plasma HMGB-1 concentrations were positively associated with increased odds of silicosis.

9. HMGB1 promotes lipopolysaccharide-induced peritoneal mesothelial cells apoptosis, which is associated with JNK1-mediated upregulation of HMGB1 acetylation.

10. HMGB1 silencing promotes tumor cells viability and arrest of pro-apoptotic proteins via Stat3/NFkappaB signaling in HepG2 cells.

11. Hepatocyte and Kupffer cell-derived HMGB1 participates in the pathogenesis of liver fibrosis by signaling through RAGE in hepatic stellate cells to activate the pMEK1/2, pERK1/2 and pcJun pathway and increase Collagen type I deposition.

12. Together, HMGB1 and p53 provided a subtle balance between autophagy and apoptosis, thus determining the fate of PCB29-Polychlorinated biphenyl quinone-treated cells

13. Study data indicated that the overexpression of HMGB1 prior to treatment was correlated with poor clinical outcome in esophageal carcinoma and that knockdown HMGB1 expression in human esophageal cancer cell lines increased their radiosensitivity by allowing the induction of apoptosis and G0/G1 arrest after exposure to radiation.

14. HMGB1 levels (and high-sensitivity C-reactive protein) are significantly higher in Parkinson's disease patients compared to controls.

15. SNPs at the rs1412125 and rs2249825 loci of HMGB1 are associated with pneumonia in terms of susceptibility, severity, and inflammatory response.

16. High HMGB1 was correlated with low survival rates and was identified as an independent prognostic factor of GBM. Knockdown of intracellular HMGB1 remarkably decreased GBM cells proliferation and invasion.

17. High expression of HMGB1 was associated with MVD and poor prognosis in clinical analyzation. Postoperative serum HMGB1 and cholangitis could predict high recurrence and unfavorable prognosis.

18. High expression of the HMGB1-TLR4 axis is closely associated with Parkinson disease development, progression, drug treatment effectiveness, staging, and disease duration and has great significance for PD diagnosis and treatment.

19. High HMGB1 expression is associated with rectal cancer.

20. miR-449a functions as a tumor suppressor in NSCLC by targeting the HMGB1-mediated NF-kappaB signaling pathway in NSCLC.

Mouse (Murine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. Findings indicate that high mobility group box 1 (HMGB1) interacts with lipopolysaccharide (LPS) to mediate caspase-11-dependent pyroptosis in lethal sepsis.

2. The data of this study showed that spinal HMGB1 was increased by ischemic stroke, and spinal HMGB1 colocalized with neurons but not microglia and astrocytes.

3. this study shows GSTP prevents sepsis-related HMGB1 Protein translocation and release

4. results indicate that HMGB1 may be an important contributor in the prevention and treatment of pneumonia of carbapenem-resistant-induced pneumonia

5. HMGB1 promotes lipopolysaccharide-induced peritoneal mesothelial cells apoptosis, which is associated with JNK1-mediated upregulation of HMGB1 acetylation.

6. Hepatocyte and Kupffer cell-derived HMGB1 participates in the pathogenesis of liver fibrosis by signaling through RAGE in hepatic stellate cells to activate the pMEK1/2, pERK1/2 and pcJun pathway and increase Collagen type I deposition.

7. DNA methyltransferases 1 (DNMT1) inhibits high-mobility group box 1(HMGB1) expression in hypoxia-induced apoptosis in cardiac progenitor cells (CPCs).

8. HMGB1 triggers immune reversal through the mobilization, redistribution, and local immune differentiation of bone marrow cells, thereby compensating for impaired immunity and leading to sufficient bacterial eradication in late-phase sepsis

9. CD11b contributes to the development of sepsis, predominantly by facilitating nucleocytoplasmic translocation and active release of HMGB1.

10. dysfunctional/diminished S1PR1 contributes to the retention of malignant cells in the surrounding tissue, constituting a minimal residual disease reservoir that later may give rise to a relapse. In DLBCL, mutations of S1PR1 have not yet been reported, but lack of membrane expression of S1PR1 in DLBCL at early stages (Ann Arbor I+II) correlates to superior outcome

11. Inhibition of NLRP3 inflammasome reduced HMGB1 expression.

12. In summary, we have demonstrated that the C-terminal tail of HMGB1 negatively regulates the interaction with TLR2.

13. High HMGB1 expression is associated with pulmonary fibrosis.

14. The up-regulation of HMGB1 was thought to be modified by dual channels: in the transcriptional level, it was regulated by JNK1/JNK2-ATF2 axis; post-transcriptionally, it was regulated by the microRNA (miR)-200 family, especially miR-429. miR-429 liver conditional knockout mice (miR-429(Deltahep)), fed either a normal diet or an HFD, showed severe liver inflammation and dysfunction, accompanied by greater expression of ...

15. This study suggested that bone cancer related hyperalgesia is driven by PKC induced phosphorylation of HMGB1, which results in its translocation from the nucleus, and releasing from the cytosol of the dorsal horn, and the activation of spinal pro-inflammatory mediators.

16. HMGB1 specifically induces the release of Th2 cytokines through GRP75-mediated enhancement of ER-Mitochondrial Ca(2+) transfer and ROS increased.

17. Results show that oxaliplatin treatment enhanced HMGB1 expression associated with immunosuppression in the colon.

18. Results suggest that high-mobility group box 1 protein (HMGB1) plays an important role on the immunogenicity of the rTcdB-treated colon carcinoma CT26 cells.

19. HMGB1 released from hypoxia/reoxygenation (H/R)- induced islets works in an autocrine manner to up-regulate STAT or p38 and augment IL-1beta production via TLR2, and up-regulate NF-kappa B and augment TNF-alpha production via TLR4 in intra-islet, which are associated with H/R-induced islet injury and early graft failure.

20. down-regulation of nuclear HMGB1 reduces ischemia-induced HMGB1 release and protects against liver IRI, which is helpful for better understanding the role of HMGB1 in organ IRI.

Cow (Bovine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. HMGB1 can act as an adjuvant in modulating the bovine immune system and thus lays a foundation for using HMGB1 as an adjuvant in various bovine vaccine preparations.

2. Single-nucleotide polymorphism in the 3'-untranslated region of the HMGB1 gene affects the binding of target bta-miR-223 and is involved in mastitis.

3. The mechanisms of interaction of the non-histone chromosomal protein HMGB1 and linker histone H1 with DNA have been studied using circular dichroism and absorption spectroscopy.

4. HMGB1 is able to induce considerable changes in DNA structure upon binding even when the amount of the protein directly associated with DNA is low

5. Interaction between non-histone chromatin protein HMGB1 and linker histone H1

6. HMGB-1 might play a role in the pathological thickening of subchondral bone plate/osteophyte formation.

7. Analysis of mechanical response generated by binding of DNA-bending protein HMGB1 to single tethered 48.5 kb lambda-DNA molecules finds that compaction of DNA increases with increasing HMGB1 concentration.

8. Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin.

Zebrafish High-Mobility Group Box 1 (HMGB1) interaction partners

1. SCARA5 is an HMGB1 recognition receptor that is negatively involved in HMGB1-mediated inflammation in pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio) models.

2. HMGB1 is a critical factor for brain development, enabling survival and proliferation of neural progenitors that will form the forebrain structures.

Pig (Porcine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. Systemic HMGB-1 levels were significantly elevated in both trauma groups when compared to the sham group. Haemorrhagic shock severity and duration were positively correlated with HMGB-1 levels and compared to baseline values, concentrations remained significantly increased in severe hemorrhage when compared to moderate hemorrhage.

2. high levels of HMGB1 in the small intestine and its relation to high levels of HMGB1 in plasma of piglets infected with E. coli O55 that suffered from infection correlated with high levels of inflammatory cytokines and bacterial translocation; levels were higher than HMGB1 levels in piglets with mild clinical symptoms

3. HMGB-1 may participate in the inflammatory response and liver injury in the late stage of acute liver failure

Horse (Equine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. High mobility group box-1 and nucleosomes might have use as biomarkers for horses with gastrointestinal disease.

2. Extracellular HMGB-1 is widespread only in synovial membrane from diseased joints in horses with osteoarthritis.

3. Osteochondral injury was associated with a significant increase in synovial HMGB-1 concentrations in horses with joint injuries, compared with results for clinically normal horses.

Rabbit High-Mobility Group Box 1 (HMGB1) interaction partners

1. Airway pressure release ventilation reduces bronchoalveolar lavage fluid HMGB1 levels and lung water, preserving oxygenation and systemic blood pressure in experimental acute respiratory distress syndrome.