Browse our anti-HMGB1 (HMGB1) Antibodies

Human High-Mobility Group Box 1 (HMGB1) interaction partners

1. HMGB1 silencing promoted the susceptibility of retinoblastoma cells to chemotherapeutic drugs through downregulating NF-kappaB (show NFKB1 Antibodies).

2. HMGB1 possesses beneficial actions, such as endothelial activation, enhancement of neurite outgrowth, and neuronal survival in ischemic stroke. [review]

3. HMGB1 mediates fibroblast activity via RAGE (show AGER Antibodies)-MAPK (show MAPK1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) signaling in keloid scar formation.

4. Serum HMGB1 may be a potential marker to monitor the surgical course in patients undergoing surgery for colorectal cancer.

5. the promotive effects of HuR (show ELAVL1 Antibodies) overexpression on the inflammatory response were attenuated when HUVECs were cotreated with HMGB1 short hairpin RNA. Therefore, the present results indicated that the ectopic expression of HuR (show ELAVL1 Antibodies) may induce inflammatory responses and thus sepsis by activating the HMGB1 signaling pathway.

6. This is the first report to examine the risk factors associated with HMGB1 SNPs in the development of Rheumatoid arthritis disease in the Chinese Han population.

7. HMGB1/IL-1beta (show IL1B Antibodies) complexes released after burn injuries can modulate immune responses

8. The HMGB1 may also be involved in mediating early stress responses in Spiral ganglion neurons(SGNs). They found that HMGB1 and p-c-Jun (show JUN Antibodies) (an activated form of an early stress-activated transcription factor) accumulated in the nuclei of the SGNs.

9. hypoxia affects tumour growth and metastasis in melanoma and depict HMGB1 as a potential therapeutic target.

10. Our study suggests that HMGB1 CSF (show CSF2 Antibodies) levels are increased in patients with anti-NMDAR (show GRIN1 Antibodies) encephalitis

Mouse (Murine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. these results suggest that miR1423p functions as a negative regulator of neuropathic pain development through the downregulation of HMGB1, indicating that miR1423p may serve as a potential therapeutic target for neuropathic pain

2. Chronic unpredictable stress (CUS) promotes significant morphological changes and causes robust upregulation of HMGB1 messenger RNA in enriched hippocampal microglia and robust and persistent upregulation of RAGE (show AGER Antibodies) messenger RNA. CUS increased surface expression of RAGE (show AGER Antibodies) protein on hippocampal microglia and anhedonic behavior. HMGB1 infusion into the hippocampus was sufficient to cause anhedonic behavior.

3. HMGB1/IL-1beta (show IL1B Antibodies) complexes released after burn injuries can modulate immune responses

4. hypoxia affects tumour growth and metastasis in melanoma and depict HMGB1 as a potential therapeutic target.

5. Chloroquine improves the response to ischemic muscle injury and increases HMGB1 after arterial ligation.

6. Data suggest high mobility group box 1 (HMGB1) expression may be associated with the protective effect of saquinavir (SQV).

7. Study shows that the disulfide form of high mobility group box-1 mediates bladder pain directly (not secondary to inflammation or injury) through activation of toll-like receptor 4 (show TLR4 Antibodies) receptors in the bladder.

8. findings suggest that HMGB1 induces the transcytosis of albumin (show ALB Antibodies) via RAGE (show AGER Antibodies)-dependent Src (show SRC Antibodies) phosphorylation and Cav-1 (show CAV1 Antibodies) phosphorylation. These studies revealed a new mechanism of HMGB1-induced endothelial hyperpermeability.

9. The injury resistance in the setting of liver fibrosis is accompanied by the inhibition of HMGB1 translocation and release as well as the suppression of HMGB1-related proinflammatory immune responses.

10. These data demonstrate that 2% H2 inhalation may be a promising therapeutic strategy for intestinal injuries caused by severe sepsis through the regulation of HO-1 (show HMOX1 Antibodies) and HMGB1 release. In addition, Nrf2 (show NFE2L2 Antibodies) plays a key role in the protective effects of H2 against intestinal damage in this disease.

Cow (Bovine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. HMGB1 can act as an adjuvant in modulating the bovine immune system and thus lays a foundation for using HMGB1 as an adjuvant in various bovine vaccine preparations.

2. Single-nucleotide polymorphism in the 3'-untranslated region of the HMGB1 gene affects the binding of target bta-miR (show MYLIP Antibodies)-223 and is involved in mastitis.

3. The mechanisms of interaction of the non-histone chromosomal protein (show HMGB2 Antibodies) HMGB1 and linker histone H1 (show H1F0 Antibodies) with DNA have been studied using circular dichroism and absorption spectroscopy.

4. HMGB1 is able to induce considerable changes in DNA structure upon binding even when the amount of the protein directly associated with DNA is low

5. Interaction between non-histone chromatin protein HMGB1 and linker histone H1 (show H1F0 Antibodies)

6. HMGB-1 might play a role in the pathological thickening of subchondral bone plate/osteophyte formation.

7. Analysis of mechanical response generated by binding of DNA-bending protein HMGB1 to single tethered 48.5 kb lambda-DNA molecules finds that compaction of DNA increases with increasing HMGB1 concentration.

8. Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin (show F2 Antibodies).

Zebrafish High-Mobility Group Box 1 (HMGB1) interaction partners

1. SCARA5 (show SCARA5 Antibodies) is an HMGB1 recognition receptor that is negatively involved in HMGB1-mediated inflammation in pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio) models.

2. HMGB1 is a critical factor for brain development, enabling survival and proliferation of neural progenitors that will form the forebrain structures.

Pig (Porcine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. Systemic HMGB-1 levels were significantly elevated in both trauma groups when compared to the sham group. Haemorrhagic shock severity and duration were positively correlated with HMGB-1 levels and compared to baseline values, concentrations remained significantly increased in severe hemorrhage when compared to moderate hemorrhage.

2. high levels of HMGB1 in the small intestine and its relation to high levels of HMGB1 in plasma of piglets infected with E. coli O55 that suffered from infection correlated with high levels of inflammatory cytokines and bacterial translocation; levels were higher than HMGB1 levels in piglets with mild clinical symptoms

3. HMGB-1 may participate in the inflammatory response and liver injury in the late stage of acute liver failure

Horse (Equine) High-Mobility Group Box 1 (HMGB1) interaction partners

1. High mobility group box-1 and nucleosomes might have use as biomarkers for horses with gastrointestinal disease.

2. Extracellular HMGB-1 is widespread only in synovial membrane from diseased joints in horses with osteoarthritis.

3. Osteochondral injury was associated with a significant increase in synovial HMGB-1 concentrations in horses with joint injuries, compared with results for clinically normal horses.

Rabbit High-Mobility Group Box 1 (HMGB1) interaction partners

1. Airway pressure release ventilation reduces bronchoalveolar lavage fluid HMGB1 levels and lung water, preserving oxygenation and systemic blood pressure in experimental acute respiratory distress syndrome.