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Our study highlights the underlying mechanism of cross interaction between ASCs and breast cancer cells, and indicates that PAG1/Cbp in breast cancer cell may modulate tumor progression and acquired chemoresistance in the ASCs-associated breast cancer microenvironment through Src (show SRC Proteins) and AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) pathways.
Up-regulated expression of CBP (show CREBBP Proteins) in Jurkat cells could reduce cell homogeneity and promote cell apoptosis
No association Pag1 mutation with patient with Schizophrenia.
The risk-associated allele of rs2370615 predisposes to allergic disease by increasing PAG1 expression, which might promote B cell activation (show BLNK Proteins) and have a pro-inflammatory effect.
CBP (show CREBBP Proteins) may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src (show SRC Proteins).
The inhibitory function of novobiocin in disrupting the HIF1alpha (show HIF1A Proteins)/p300 (show EP300 Proteins) complex might be important in tumor cell growth.
siRNA directed against PAG1 in a radioresistant (Hep-2max) cell line dramatically enhanced the radiosensitivity and IR-induced cell death.
expression of CBP (show CREBBP Proteins) gene is decreased in esophageal carcinoma, which might contribute to the tumorigenesis and progression.
An over-expression of PAG1 in PC-3M-1E8 cells effectively suppresses the activation of Ras and ERK (show EPHB2 Proteins), as well as the cyclin D1 (show CCND1 Proteins) expression, leading to an inhibition of the proliferation ability of tumor cells.
Cbp (show CREBBP Proteins) down-regulation is primarily mediated by epigenetic histone modifications via oncogenic MAPK (show MAPK1 Proteins)/PI3K (show PIK3CA Proteins) pathways in a subset of cancer cells.
Inducible knockdown of PAPP-A (show PAPPA Proteins) gene expression in adult female mice extends life span.
Intrinsic mitochondrial oxidative capacity was significantly increased in skeletal muscle of aged PAPP-A (show PAPPA Proteins) KO compared to WT mice. Moreover, 18-month-old PAPP-A (show PAPPA Proteins) KO mice exhibited significantly enhanced endurance running on a treadmill. Thus, PAPP-A (show PAPPA Proteins) deficiency in mice is associated with indices of healthy skeletal muscle function with age.
our findings illustrate that Cbp (show CREBBP Proteins) is an important regulator of Csk (show CSK Proteins) recruitment to the SFK Lyn (show LYN Proteins) in Eporesponsive erythroid cells.
Snell, GHKRO, and PAPPA (show PAPPA Proteins)-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT (show MGMT Proteins)) and N-myc downstream-regulated gene 1 (NDRG1 (show NDRG1 Proteins)).
STC2 (show STC2 Proteins) is involved in regulating PAPP-A (show PAPPA Proteins) activity during the development of atherosclerosis
Study demonstrates proof-of-principle and provides feasibility for a novel therapeutic strategy to inhibit atherosclerotic plaque burden by selective targeting of PAPP-A (show PAPPA Proteins).
stimulation of PAPP-A (show PAPPA Proteins) expression by intermittent PTH (show PTH Proteins) treatment contributes to PTH (show PTH Proteins) bone anabolism in mice
PAPP-A (show PAPPA Proteins) affects fascicle structure, thereby affecting tendon phenotype.
This study demonstrated that cbp (show CREBBP Proteins) increase in skeletal muscle in muscle atrophy.
PAG is constitutively phosphorylated in resting T cells and rapidly dephosphorylated once the TCR is engaged.
The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.
phosphoprotein associated with glycosphingolipid microdomains 1
, phosphoprotein associated with glycosphingolipid-enriched microdomains 1-like
, Csk-binding protein
, phosphoprotein associated with glycosphingolipid-enriched microdomains 1
, transmembrane adapter protein PAG
, transmembrane adaptor protein PAG
, transmembrane phosphoprotein Cbp
, Csk binding protein
, csk-binding protein
, phosphoprotein transmembrane adaptor 1
, phosphoprotein-associated with GEMs
, IGF-dependent IGFBP-4 protease
, insulin-like growth factor-dependent IGF-binding protein 4 protease