Browse our PAG1 Proteins (PAG1)

Mouse (Murine) phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1) interaction partners

1. our findings illustrate that Cbp (show CREBBP Proteins) is an important regulator of Csk (show CSK Proteins) recruitment to the SFK Lyn (show LYN Proteins) in Eporesponsive erythroid cells.

2. This study demonstrated that cbp (show CREBBP Proteins) increase in skeletal muscle in muscle atrophy.

3. PAG is constitutively phosphorylated in resting T cells and rapidly dephosphorylated once the TCR is engaged.

4. If Cbp enhances the interaction between c-Src and FAK, Cbp could promote c-Src function when lipid rafts are disrupted.

5. PAG (show PRDX1 Proteins) can function as both a positive and a negative regulator of mast cell signaling, depending upon the signaling pathway involved. PAG (show PRDX1 Proteins) is a positive regulator of passive systemic anaphylaxis.

6. Data show that the phosphoprotein associated with glycosphigolipid-enriched microdomains (PAG)/Csk binding protein (Cbp) modulates SFK activity in the brain.

7. Cbp plays a role in adult hematopoietic stem cell homeostasis.

8. Cbp (show CREBBP Proteins) down-regulation is primarily mediated by epigenetic histone modifications via oncogenic MAPK (show MAPK1 Proteins)/PI3K pathways in a subset of cancer cells.

9. expression of Cbp is downregulated during osteoclast differentiation, consequently inhibiting recruitment of Csk to lipid rafts and keeping c-Src activity high in osteoclasts. findings provide a novel paradigm that controls c-Src activity in osteoclasts.

10. CBP (show CREBBP Proteins) plays a role in transiently anchoring Thy-1 (show THY1 Proteins) to the cytoskeleton.

Human phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1) interaction partners

1. Low PAG1 expression is associated neuroblastoma (show ARHGEF16 Proteins).

2. Our study highlights the underlying mechanism of cross interaction between ASCs and breast cancer cells, and indicates that PAG1/Cbp in breast cancer cell may modulate tumor progression and acquired chemoresistance in the ASCs-associated breast cancer microenvironment through Src (show SRC Proteins) and AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) pathways.

3. Up-regulated expression of CBP (show CREBBP Proteins) in Jurkat cells could reduce cell homogeneity and promote cell apoptosis

4. No association Pag1 mutation with patient with Schizophrenia.

5. The risk-associated allele of rs2370615 predisposes to allergic disease by increasing PAG1 expression, which might promote B cell activation (show BLNK Proteins) and have a pro-inflammatory effect.

6. CBP (show CREBBP Proteins) may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src (show SRC Proteins).

7. The inhibitory function of novobiocin in disrupting the HIF1alpha (show HIF1A Proteins)/p300 (show EP300 Proteins) complex might be important in tumor cell growth.

8. siRNA directed against PAG1 in a radioresistant (Hep-2max) cell line dramatically enhanced the radiosensitivity and IR-induced cell death.

9. expression of CBP (show CREBBP Proteins) gene is decreased in esophageal carcinoma, which might contribute to the tumorigenesis and progression.

10. An over-expression of PAG1 in PC-3M-1E8 cells effectively suppresses the activation of Ras and ERK (show EPHB2 Proteins), as well as the cyclin D1 (show CCND1 Proteins) expression, leading to an inhibition of the proliferation ability of tumor cells.