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anti-Human Peroxiredoxin 1 Antibodies:
anti-Mouse (Murine) Peroxiredoxin 1 Antibodies:
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Human Polyclonal Peroxiredoxin 1 Primary Antibody for ICC, IF - ABIN4344918
OLeary, Terrile, Bajor, Gaj, Hennessy, Mills, Zagozdzon, OConnor, Brennan, Connor, Li, Gonzalez-Angulo, Sun, Pu, Pontén, Uhlén, Jirström, Nowis, Crown, Zagozdzon, Gallagher: Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer. in Breast cancer research : BCR 2014
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Human Monoclonal Peroxiredoxin 1 Primary Antibody for WB - ABIN2476045
Wray, Prochaska, Fisher, Shaker: Traumatic pericardial hematoma simulating tricuspid valve obstruction. in The Johns Hopkins medical journal 1976
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Human Polyclonal Peroxiredoxin 1 Primary Antibody for IF (p), IHC (p) - ABIN750478
Sun, Zhu, Wang, Lv, Zhou, Yu, Xu, Ma, Zhong, Jia: Diagnostic and prognostic significance of peroxiredoxin 1 expression in human hepatocellular carcinoma. in Medical oncology (Northwood, London, England) 2013
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Human Polyclonal Peroxiredoxin 1 Primary Antibody for IF (p) - ABIN912097
Szabó-Taylor, Tóth, Balogh, Sódar, Kádár, Pálóczi, Fekete, Németh, Osteikoetxea, Vukman, Holub, Pállinger, Nagy, Winyard, Buzás: Monocyte activation drives preservation of membrane thiols by promoting release of oxidised membrane moieties via extracellular vesicles. in Free radical biology & medicine 2017
Human Monoclonal Peroxiredoxin 1 Primary Antibody for ELISA, WB - ABIN562097
Hirahashi, Koga, Kumagai, Aishima, Taguchi, Oda: Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients. in Pathology international 2014
Human Monoclonal Peroxiredoxin 1 Primary Antibody for ELISA, WB - ABIN450086
Araki, Kusano, Sasaki, Tanaka, Hatta, Fukui, Natsume: Redox Sensitivities of Global Cellular Cysteine Residues under Reductive and Oxidative Stress. in Journal of proteome research 2016
Human Polyclonal Peroxiredoxin 1 Primary Antibody for ELISA, WB - ABIN451613
Jönsson, Johnson, Lowther: Structure of the sulphiredoxin-peroxiredoxin complex reveals an essential repair embrace. in Nature 2008
PRDX1 expression is low in osteosarcoma and fibrosarcoma tumors. PRDX1 suppressed the progression and metastasis of osteosarcoma and fibrosarcoma cells.
The mRNA and protein levels of Prdx1 in the GC tissues were higher than in the peri (show PLIN1 Antibodies)-tumor tissues. Authors also found that high Prdx1 expression was positively correlated with the lymph node invasion and poor prognosis.
these data ascertain the existence of an H2O2-sensitive PRDX1-FOXO3 (show FOXO3 Antibodies) signaling axis that fine tunes FOXO3 (show FOXO3 Antibodies) activity toward the transcription of gene targets in response to oxidative stress.
PRDX1 and MTH1 (show NUDT1 Antibodies) cooperate to prevent accumulation of oxidized guanine in the genome
Study uncovered a novel interaction between APE1 (show APEX1 Antibodies) and PRDX1, which existed in both the nuclear and cytosolic fractions. Its knockdown enhances APE1 (show APEX1 Antibodies) detection in the nucleus and stimulates IL-8 (show IL8 Antibodies) expression. Also, in gastric cancer patients, PRDX1 mRNA expression level is reduced and correlates with poor survival.
Median PRDX1 levels were significantly higher in stroke patients compared to controls.
The epimutation is present in three generations and results from PRDX1 mutations that force antisense transcription of MMACHC (show MMACHC Antibodies).
Peroxiredoxin I (Prx (show PRDX6 Antibodies) I) increased in tumors of hepatocellular carcinoma (HCC (show FAM126A Antibodies)) patients that aligned with overexpression of oncogenic H-ras (show HRAS Antibodies).
Prx1 might play an oncogenic role in tobacco-related oral squamous cell carcinoma and thus serve as a target for chemopreventive and therapeutic interventions.
PRDX1 safeguards telomeres from oxygen radicals to counteract telomere damage and preserve telomeric DNA for elongation by telomerase.
These phenomena increased liver apoptosis through increasing cleaved caspase3 protein expression in Prx (show PRX Antibodies) I/ mice after LPS (show TLR4 Antibodies) injections, resulting in high lethality after LPS (show TLR4 Antibodies) challenges. These findings provide a new insight for understanding the function of Prx (show PRX Antibodies) I against endotoxininduced injury.
Data suggests that Prdx1 and Prdx2 (show PRDX2 Antibodies) in pronuclei of zygotes are involved in antioxidant mechanisms and epigenetic programming during maternal-to-zygotic transition (during ectogenesis following in vitro fertilization). PRDX1 and PRDX2 (show PRDX2 Antibodies) appear to be ninth and twenty-second highest expressed proteins, respectively, among 64 proteins identified in mouse zygotes.
Prdx1 knockout can aggravate the oxidative stress and lung injury by increasing the level of Reactive Oxygen Species (ROS (show ROS1 Antibodies)), and also activate P38 (show CRK Antibodies)/JNK (show MAPK8 Antibodies) signaling pathway.
PRX1 and PRX5 (show PRDX5 Antibodies) were upregulated in osteoblasts in the proximal tibial metaphysis of ovariectomized mice. Interestingly, PRX1 and PRX5 (show PRDX5 Antibodies) showed different distribution patterns, with PRX1 mainly accumulated in cell nuclei and PRX5 (show PRDX5 Antibodies) in the cytoplasm.
HDAC6 (show HDAC6 Antibodies) inhibition and the regulation of Prx1 activity may play a significant role in protecting retinal cells and in particular photoreceptors.
This is the first report proclaiming that the ESAT-6 regulates Prdx-1 which is involved in the increase of mycobacterial uptake and survival. The intermediate mechanisms involve the increased Prdx-1 production in macrophages through the activation of p38 (show CRK Antibodies) and NRF-2 (show NFE2L2 Antibodies) dependent signaling.
in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells.
These findings suggest that extracellular Prx1-mediated TLR4 (show TLR4 Antibodies)/NF-kappaB (show NFKB1 Antibodies) pathway activation probably contributes to neuroinflammatory injury after ICH (show ACE Antibodies), and thus blocking Prx1-TLR4 (show TLR4 Antibodies) signaling might provide a novel anti-neuroinflammatory strategy with extended therapeutic window for hemorrhagic stroke
This study demonstrated that Prdx1 showed a distinct nuclear localization in the spinal cord also present in the nucleus of dorsal root ganglia (DRG) cells as well as in the sensory nerve root in embryonic development.
Prx I and Prx II appear to have a tight association with the mechanism underlying the protection of ESC stemness in developing teratomas.
These results suggest that PRX 1 is a novel mechanosensitive antioxidant, playing an important role in shear-dependent regulation of endothelial biology and atherosclerosis.
It was assumed that Prx1 plays a leading role in X. laevis early development.
The results suggested that scarless skin-wound healing may require activation of the prx1 limb enhancer, and competence to activate the enhancer is probably a prerequisite for epimorphic regeneration, such as limb regeneration.
this paper shows immunotimulatory function of peroxiredoxin 1 in activating adaptive humoral immunity in a zebrafish model
HDAC6 (show HDAC6 Antibodies) inhibition and the regulation of Prx1 (show PRRX1 Antibodies) activity may play a significant role in protecting retinal cells and in particular photoreceptors.
Data suggest a role for peroxiredoxin1 (Prdx1) in vasculature and indicating that the antioxidant function of prdx1 is important.
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene.
natural killer cell-enhancing factor A
, natural killer-enhancing factor A
, proliferation-associated gene A
, proliferation-associated gene protein
, thioredoxin peroxidase 2
, thioredoxin-dependent peroxide reductase 2
, Trx dependent peroxide reductase 2
, macrophage 23 Kd stress protein
, macrophage 23 kDa stress protein
, macrophage 23kDa stress protein
, macrophase stress protein 22kDa
, macrophase stress protein 23 kd
, osteoblast specific factor 3
, osteoblast-specific factor 3
, thioredoxin dependent peroxide reductase 2
, heme-binding 23 kDa protein
, peroxiredoxin 1
, Thioredoxin peroxidase 2
, thioredoxin peroxidase II