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maspin is a powerful context-dependent tumor suppressor.
these data indicate that SerpinB5 expression and phosphorylation are developmentally regulated. In vitro analyses indicate that SerpinB5 phosphorylation is regulated by EGFR (show EGFR Proteins) ligands, but EGF (show EGF Proteins) appears to be the only able to induce SerpinB5 nuclear localization.
perturbation of genes near maspin may in fact explain poor survival in certain patient cohorts with low maspin expression
evidence demonstrates that D(346) is a critical cis (show CISH Proteins)-element in maspin sequence that determines the molecular context and subcellular localization of maspin.
a novel mechanism by which maspin utilizes its cysteine thiols to inhibit oxidative stress and cell growth.
results suggest that maspin, a tumor suppressor, may play an important role in embryo implantation
The nuclear localization of maspin is required for its tumor and metastasis suppressor functions in vivo.
SERPINB5 and AKAP12 may have a role in increased metastasis in pancreatic ductal adenocarcinoma
PAR-1 (show MARK2 Proteins) negatively regulates the expression of the Maspin tumor-suppressor gene in the acquisition of the metastatic melanoma phenotype
Results describe a mechanism by which maspin exerts its effect on endothelial cell adhesion and migration through an integrin signal transduction pathway.
Study results provide new insights into the molecular mechanisms of maspin suppression in response to HBx, and revealed nuclear IKKalpha (show CHUK Proteins) as a prognostic biomarker and a potential therapeutic target to improve the clinical outcome of HBV-associated HCC (show FAM126A Proteins) patients.
Mechanistic investigations found that quercetin suppressed Snail (show SNAI1 Proteins)-dependent Akt (show AKT1 Proteins) activation by upregulating maspin and Snail (show SNAI1 Proteins)-independent a disintegrin and metalloproteinase (ADAM) 9 (show ADAM9 Proteins) expression pathways to modulate the invasive ability of NSCLC cells.
High HDAC1 (show HDAC1 Proteins) expression may contribute to the aggressiveness of human breast cancer with cytoplasmic-only expression of maspin
These results reveal a novel biological function of Maspin in modulating macrophage activity
Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer.
Impact of Maspin Polymorphism rs2289520 G/C and Its Interaction with Gene to Gene, Alcohol Consumption Increase Susceptibility to Oral Cancer Occurrence
Cytoplasmic expression of maspin could be an independent unfavourable prognostic indicator in patients with lung squamous cell carcinoma (SCC (show CYP11A1 Proteins)).
Results demonstrated that Maspin suppressed growth, proliferation and invasion by delaying cell cycle transition and promoting apoptosis in cutaneous squamous cell carcinoma cells.
This is the first time that these parts of maspin have been highlighted as having key roles affecting cell function
In GC with associated metaplasia, cytoplasmic maspin is predominant; the nuclear shift induces local aggressiveness and risk of node metastases, whereas total loss can indicate a risk of distant metastases
may act as a tumor suppressor
peptidase inhibitor 5
, protease inhibitor 5
, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
, serine (or cysteine) proteinase inhibitor, clade B, member 5
, serine protease inhibitor 7
, serpin B5
, protease inhibitor 5 (maspin)
, serine (or cysteine) peptidase inhibitor, clade B, member 5