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Results show that XPC deficiency leads to alterations in mitochondrial redox balance with a respiratory complex CI/CII shift as a possible adaptation to lower CI activity, but at the cost of sensitizing XP-C cells to mitochondrial oxidative stress.
Chronic low-dose of UVB (CLUV) treatment activates p53 (show TP53 Proteins), which corroborate with the increased level of DDB2 (show DDB2 Proteins) and XPC proteins. DDB2 (show DDB2 Proteins) and XPC recruited at chromatin bound, suggesting a more efficient cyclobutane pyrimidine dimer (CPD (show CPD Proteins)) recognition by NER (show NR1H2 Proteins) and more efficient repair of CDP (show CUX1 Proteins).
Demethylation using decitabine increased XPC and apoptosis after sequential carboplatin. These results confirm that sequential decitabine and carboplatin requires further investigation as a combination treatment for melanoma.
These findings support that loss of XPC, possibly due to chronic Cigarette smoke exposure, promotes emphysema development and further supports a link between DNA damage, impaired DNA repair, and development of emphysema.
Poly(ADP-ribose) polymerase-1 (PARP1 (show PARP1 Proteins)) interacts with xeroderma pigmentosum, complementation group C protein (XPC) in the nucleoplasmic and chromatin fractions in UV irradiated HEK293 cells.
hospital workers as a category are at risk for genotoxic damage caused by chronic exposure to xenobiotics. The higher levels of cytogenetic damage observed among GSTT1 (show GSTT1 Proteins) null, XPD (show ERCC2 Proteins) 751 and XPC 939 CC homozygote subjects confirm the importance of the genetic polymorphisms analysis associated to genotoxicological studies.
XPC Ala499Val substitution increases urinary bladder cancer risk, but Lys939Gln appears to be neutral. (Meta-analysis)
low XPC and global genome repair have roles in reduced repair of UVB-induced DNA damage in melanoma
Several mutations in the two parts of the central "crest" of the arrestin (show SAG Proteins) molecule, middle-loop and C-loop, enhanced or reduced arrestin-3 (show ARRB2 Proteins) interactions with several GPCRs in receptor subtype and functional state-specific manner.
these studies found that carriers of the T allele of ERCC1 (show ERCC1 Proteins) rs11615, XPC rs2228000 and rs50872, particularly in postmenopausal females, have an increased risk of breast cancer
results suggest that XPC may help repair DNA damage caused by KRAS-mediated production of ROS (show ROS1 Proteins).
OCT4 (show POU5F1 Proteins) and SOX2 (show SOX2 Proteins) are the primary transcription factors recruiting SCC (show CYP11A1 Proteins) to regulatory regions of pluripotency genes; the XPC subunit is essential for interaction with the two proteins
progerin and p16(INK4a) expression, beta-galactosidase (show GLB1 Proteins) activity, and reactive oxygen species, which increase with age, were higher in young Xpc(-/-) mice than in young Xpc(+/+) ones
Study indicates that Xpc(-/-) mice have an increased mutational load upon induction of oxidative stress. The effect of non-functional XPC in vivo appears to have implications in mutagenesis, which can contribute to the carcinogenesis process.
The C-terminal region of Xpc is dispensable for the transcriptional activity of Oct3/4 (show POU5F1 Proteins) in mouse embryonic stem cells.
BRAF (show BRAF Proteins)(V600E) and ARF deletion synergize to inhibit nucleotide excision repair by epigenetically repressing XPC.
Dysmyelination not demyelination causes neurological symptoms in preweaned mice in a cs-b xp-c murine model of Cockayne syndrome
analysis of mHR23A/B double-mutant cells showed that HR23 proteins function in nucleotide excision repair by governing xeroderma pigmentosum group C protein stability via partial protection against proteasomal degradation
mutational hot spot is not at a dipyrimidine site and is apparently Xpc-specific, suggesting some form of non-dipyrimidine base damage is normally repaired in a manner distinct from conventional nucleotide excision repair, but that requires XPC protein
Deletion of Gadd45a (show GADD45A Proteins) alone does not lead to increased lung tumors in mice, but coupled with an XPC deletion, it results in lung tumor progression
This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
xeroderma pigmentosum, complementation group C
, DNA repair protein complementing XP-C cells
, mutant xeroderma pigmentosum group C
, DNA repair protein complementing XP-C cells homolog
, xeroderma pigmentosum group C-complementing protein homolog