FK506 Binding Protein 4, 59kDa (FKBP4) (C-Term) Peptide
FKBP4
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all FKBP4 products
- FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- EKKLYANMFE RLAEEENKAK AEASSGDHPT DTEMKEEQKS NTAGSQSQVE
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- FKBP4 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))
- Background
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The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.
Alias Symbols: HBI, p52, Hsp56, FKBP51, FKBP52, FKBP59, PPIase
Protein Size: 459 - Gene ID
- 2288
- NCBI Accession
- NM_002014, NP_002005
- UniProt
- Q02790
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