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Cell Division Cycle 27 Homolog (S. Cerevisiae) (CDC27) (Middle Region) Peptide

CDC27 Reactivity: Human Host: Synthetic BP, WB
Catalog No. ABIN974728
  • Target See all CDC27 products
    CDC27 (Cell Division Cycle 27 Homolog (S. Cerevisiae) (CDC27))
    Protein Region
    Middle Region
    Origin
    Human
    Source
    • 3
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Sequence
    KLKMKFPPKI PNRKTKSKTN KGGITQPNIN DSLEITKLDS SIISEGKIST
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-CDC27 Antibody(ARP43603_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    CDC27 (Cell Division Cycle 27 Homolog (S. Cerevisiae) (CDC27))
    Background
    The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

    Alias Symbols: APC3, CDC27Hs, D0S1430E, D17S978E, HNUC, NUC2, ANAPC3

    Protein Interaction Partner: FZR1,PIN1,ANAPC10,ANAPC2,ANAPC7,BUB1B,CASP3,CDC16,CDC20,CDC26,FZR1,HOXC10,MAD2L1,PIN1,PPP5C,RB1,SKIL,SMAD2,SMAD3,ANAPC1,ANAPC10,ANAPC11,ANAPC2,ANAPC4,ANAPC5,ANAPC7,APC2,BUB1B,CCNB1,CDC16,CDC20,CDC23,CDC26,CDH1,CDKN1A,CTNNB1,FZR1,MAD2L1,PIN1,PPP5C,PTTG1,Pp

    Protein Size: 824
    Molecular Weight
    92 kDa
    Gene ID
    996
    NCBI Accession
    NM_001256, NP_001247
    UniProt
    P30260
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