Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (C-Term) Peptide
CTNNB1
Reactivity: Human
Host: Synthetic
BP, WB, ChIP
Catalog No. ABIN975425
Quick Overview for Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (C-Term) Peptide (ABIN975425)
Target
CTNNB1
(Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)
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Protein Region
- C-Term
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Sequence
- LGLDIGAQGE PLGYRQDDPS YRSFHSGGYG QDALGMDPMM EHEMGGHHPG
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CTNNB1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))
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Background
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The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
Alias Symbols: CTNNB, DKFZp686D02253, FLJ25606, FLJ37923
Protein Size: 781 -
Molecular Weight
- 85 kDa
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Gene ID
- 1499
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NCBI Accession
- NM_001904, NP_001895
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UniProt
- P35222
Target
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