Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (Middle Region) Peptide
FGR
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN976849
Quick Overview for Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (Middle Region) Peptide (ABIN976849)
Target
Fgr (FGR)
(Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- CPPGCPASLY EAMEQTWRLD PEERPTFEYL QSFLEDYFTS AEPQYQPGDQ
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-FGR Antibody(ARP54523_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) peptide
FGR Reactivity: Human, Mouse, Rat, Dog Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Fgr (FGR) (Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR))
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Background
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This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Alias Symbols: FLJ43153, MGC75096, SRC2, c-fgr, c-src2, p55c-fgr, p58c-fgr, p55-Fgr, p58-Fgr
Protein Interaction Partner: ARRB1,CBL,CCR3,CD24,CSK,DAB2,DOK1,FGR,HCLS1,INPP5D,PTK2,SLAMF1,SNCA,SRC,SYK,VDR,WAS,YWHAQ,CBL,CCR3,CD24,DAB2,DOK1,FASLG,HCLS1,IKBKG,NCOA6,PTK2,SLAMF1,SYK,WAS
Protein Size: 529 -
Molecular Weight
- 59 kDa
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Gene ID
- 2268
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NCBI Accession
- NM_001042729, NP_001036194
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UniProt
- P09769
Target
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