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Collier, Fueger, Hohmeier, Newgard: Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines. in Diabetes 2006
Show all 5 Pubmed References
Human AKT ELISA Kit for Sandwich ELISA - ABIN625220
Sharma, Yang, Xi, Grotta, Aronowski, Savitz: IL-10 directly protects cortical neurons by activating PI-3 kinase and STAT-3 pathways. in Brain research 2011
Human AKT ELISA Kit for Sandwich ELISA - ABIN625233
Wang, Rayes, Elahi, Lu, Hancock, Massie, Rowe, Aomari, Hossain, Durocher, Pinard, Tabariès, Siegel, Brodt: The IGF-Trap: Novel Inhibitor of Carcinoma Growth and Metastasis. in Molecular cancer therapeutics 2015
Mouse (Murine) AKT ELISA Kit for Sandwich ELISA - ABIN425439
Campo, Avenoso, DAscola, Scuruchi, Calatroni, Campo: Beta-arrestin 1 is involved in the catabolic response stimulated by hyaluronan degradation in mouse chondrocytes. in Cell and tissue research 2015
Rat (Rattus) AKT ELISA Kit for Competition ELISA - ABIN772316
Waghe, Sarath, Gupta, Kandasamy, Choudhury, Kutty, Mishra, Sarkar: Arsenic causes aortic dysfunction and systemic hypertension in rats: Augmentation of angiotensin II signaling. in Chemico-biological interactions 2015
Rat (Rattus) AKT ELISA Kit for Sandwich ELISA - ABIN367995
Jain, Suryakumar, Prasad, Ganju: Differential activation of myocardial ER stress response: a possible role in hypoxic tolerance. in International journal of cardiology 2013
we have found that SNG inhibits Akt, a key anti-apoptotic protein kinase (show CDK7 ELISA Kits) by dephosphorylating it at Ser (show SIGLEC1 ELISA Kits)(473), leading to the dephosphorylation of its downstream targets, GSK3beta (show GSK3b ELISA Kits) and mTOR (show FRAP1 ELISA Kits)
Results show that macrophages in the renal cell carcinoma (RCC (show XRCC1 ELISA Kits)) tumor microenvironment could increase RCC (show XRCC1 ELISA Kits) metastasis via activation of the AKT/mTOR (show FRAP1 ELISA Kits) signals.
these results indicate that PAK4 (show PAK4 ELISA Kits) confers CDDP resistance via the activation of MEK (show MAP2K1 ELISA Kits)/ERK (show EPHB2 ELISA Kits) and PI3K (show PIK3CA ELISA Kits)/Akt pathways. PAK4 (show PAK4 ELISA Kits) and PI3K (show PIK3CA ELISA Kits)/Akt pathways can reciprocally activate each other.
AQP9 (show AQP7 ELISA Kits) overexpression decreased the protein levels of phosphatidylinositol-3-kinase (PI3K (show PIK3CA ELISA Kits)), leading to reduced phosphorylation of Akt, and subsequently the protein levels of forkhead box protein O1 (FOXO1 (show FOXO1 ELISA Kits)) were increased.
PI3Kdelta and PI3Kgamma (show PIK3CG ELISA Kits) inhibition with IPI-145 has anti-proliferative activity in primary AML (show RUNX1 ELISA Kits) cells by inhibiting the activity of AKT and MAPK (show MAPK1 ELISA Kits)
data show that ErbB2 and Akt are important for CNC migration and implicate other ErbB receptors and Akt-independent signaling pathways. Our findings provide the first example of a functional interaction between the extracellular domain of a type II classical cadherin and growth factor receptors
High AKT1 expression is associated with malignant pleural mesothelioma.
IGF-II siRNA inactivates the FAK (show PTK2 ELISA Kits)/PI3K (show PIK3CA ELISA Kits)/Akt signaling pathway, and further reduces cell proliferation, N-ras (show NRAS ELISA Kits) and C-myc (show MYC ELISA Kits) levels in SMMC-7721 cells.
resistant tumors display high Akt activation and a combined treatment with AKT inhibitors causes synergistic tumour growth inhibition in vitro and in vivo
Studies suggest to maximize therapeutic benefit, drug combinations and schedules for Inhibition of the PI3K (show PIK3CA ELISA Kits)/AKT/mTOR (show FRAP1 ELISA Kits) Pathway must be explored to identify those with the highest efficacy and lowest toxicity overlap.
this study reveals the function of IL-15 (show IL15 ELISA Kits) in astrocyte survival via Akt phosphorylation in response to OGD (show FGFR1 ELISA Kits)-induced damage.
This study demonstrates the neuroprotective effect of TSG (show TWSG1 ELISA Kits) on APP (show APP ELISA Kits) expression, suggesting that TSG (show TWSG1 ELISA Kits) may be beneficial for AD prevention and treatment.
Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.
Despite higher endogenous insulin (show INS ELISA Kits) concentrations following feeding, arcuate nucleus phosphorylation of Akt (pAkt) levels were significantly lower in the pregnant group compared with the nonpregnant group.
Setdb1 (show SETDB1 ELISA Kits) regulates PTEN/AKT/FOXO1 (show FOXO1 ELISA Kits) pathway to inhibit Spermatogonial stem cells apoptosis.
These findings indicate that IGF-II reduces PGC-1alpha (show PPARGC1A ELISA Kits) expression in skeletal muscle cells through a mechanism involving PI3K-Akt-FoxO1 (show FOXO1 ELISA Kits) but not p38 MAPK (show MAPK14 ELISA Kits) or Erk1/2 (show MAPK1/3 ELISA Kits) MAPK (show MAPK1 ELISA Kits) pathways.
Ablation of Cyclophilin D (show PPIF ELISA Kits) Results in an Activation of FAK (show PTK2 ELISA Kits), Akt, and ERK (show EPHB2 ELISA Kits) Pathways in the Mouse Heart.(
These results reveal a novel signaling network, the Sema4D (show SEMA4D ELISA Kits)-RhoA (show RHOA ELISA Kits)-Akt signal cascade, that coordinates cellular function and morphology and highlights the importance of specific spatiotemporally restricted components of a signaling pathway in the regulation of ameloblast differentiation.
This is perhaps the first report demonstrating that AKT1 signaling prevailing in the mesenchymal stem cells regulates hematopoietic stem cell functionality through various intercellular communication mechanisms.
L. donovani triggered AKT activation to regulate GSK-3beta (show GSK3b ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits)/FOXO-1 (show FOXO1 ELISA Kits) axis.
The metabolic defects of cycG (show CCNG1 ELISA Kits) mutant animals are abrogated by a concomitant loss of Wdb, CycG (show CCNG1 ELISA Kits) presumably influences Akt1 activity at the PP2A nexus; Well rounded (Wrd), another B' subunit of PP2A in Drosophila, binds CycG (show CCNG1 ELISA Kits) similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG (show CCNG1 ELISA Kits) mutants.
Our findings demonstrated that lovastatin restored LRRK2 (show LRRK2 ELISA Kits)-G2019S neurite degeneration by augmenting Akt/NRF2 (show NFE2L2 ELISA Kits) pathway and inhibiting downstream GSK3b (show GSK3b ELISA Kits) activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2 (show LRRK2 ELISA Kits)-G2019S parkinsonism.
These findings revise the existing spermiation model in Drosophila and suggest that somatic cells can actively oppose mechanical cell invasion attempts using calibrated F-actin dynamics in situ
subtle manipulation of foxo through Akt1 can enhance survival during adverse nutrient conditions in Drosophila.
The developmental delay of these novel Akt1 hypomorphs results in a latent phenotype uncovered by generation of somatic clones
these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation
AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.
Akt1 governs two critical elements of synapse development, neurotransmitter receptor (show GRIN1 ELISA Kits) localization, and postsynaptic membrane elaboration
Tsc2 (show TSC2 ELISA Kits) mutants showed a dramatic decrease in the levels of phosphorylated Akt, and interestingly, Akt mutants phenocopied Tsc2 (show TSC2 ELISA Kits) mutants, leading to the hypothesis that Tsc2 (show TSC2 ELISA Kits) and Akt might work via the same genetic pathway to regulate synapse growth.
Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity.
This study showed that beta-actin (show ACTB ELISA Kits), L32 (show RPL32 ELISA Kits) ribosomal protein, and ATP5B (show ATP5B ELISA Kits) proteins were the most stabily expressed genes in cryopreserved horse semen.
the measurement of levels of PI3K-Akt pathway components in FCs from ovarian follicles carrying oocytes with distinct developmental competences is a useful tool to identify putative molecular pathways involved in the acquisition of oocyte competence.
These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 (show CTNNB1 ELISA Kits) accumulation and subsequent ovarian E2 production.
Caveolin-1 (show CAV1 ELISA Kits) scaffolding domain residue phenylalanine 92 modulates Akt signaling
TG2 (show TGM2 ELISA Kits) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.
results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta (show GSK3b ELISA Kits), and NF-kappaB (show NFKB1 ELISA Kits).
The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (show NOX1 ELISA Kits), reactive oxygen species, and PI3-kinase (show PIK3CA ELISA Kits) in stimulated NO release.
PI3K/Akt and p53 (show TP53 ELISA Kits) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide
Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR (show FRAP1 ELISA Kits), p70S6K (show RPS6KB1 ELISA Kits), and ERK1/2 (show MAPK1/3 ELISA Kits).
Gab1 tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B and endothelial nitric-oxide synthase (show NOS3 ELISA Kits) activation in endothelial cells
Losartan metabolite stimulates eNOS (show NOS3 ELISA Kits) phosphorylation and suppresses tumor necrosis factor alpha (show TNF ELISA Kits)-induced endothelial cell apoptosis by activating AKT1.
These findings highlight novel and essential roles of PFKFB4 (show PFKFB4 ELISA Kits) activity in later stages of neural crest (NC) development that are wired into the NC gene regulatory network.
SCF (show KITLG ELISA Kits) is a critical regulatory factor for conceptus development and implantation during pregnancy in pigs.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR (show FRAP1 ELISA Kits)-FOXO1 (show FOXO1 ELISA Kits) signaling and suppressing the activation of TLR4 (show TLR4 ELISA Kits) and/or NOD2 (show NOD2 ELISA Kits) signaling pathways.
Data show that homocysteine (Hcy) can ameliorate the endothelium-independent hypoxic coronary vasoconstriction, in which the inhibition of PI3K/Akt signaling pathway may be involved.
In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 could positively regulate lactose synthesis.
In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.
Host PI3K and Akt1 play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.
Activity of AKT is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.
IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.
findings show that megalin (show LRP2 ELISA Kits) is the sensor that determines whether cells will be protected or injured by albumin (show ALB ELISA Kits); it binds protein kinase B (PKB) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB in the luminal plasma membrane [
protein kinase B (PKB/Akt)was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea
CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.
results suggest that NO decreases K(+) absorption by promoting the synthesis of vitamin B6 PLP (show FNTA ELISA Kits), which further represses the activity of K(+) channel (show KCNC4 ELISA Kits) AKT1 in Arabidopsis.
Examination of the athak5 atakt1 double mutant, revealing novel aspects of an uptake system as yet unidentified by genetic means.
AKT1 is regulated by CIPK23 in guard cells and is involved in water stress responses.
These findings provide further insights into the signaling network consisting of CBL (show CBL ELISA Kits)-CIPK-PP2C interactions in the activation of the AKT1 channel.
Electrophysiological results showed that AtKC1 inhibited the AKT1-mediated inward K(+) currents and negatively shifted the voltage dependence of AKT1 channels.
AtHAK5 and AKT1 are vital for plant growth and development at low K+ concentrations.
In the range between 0.01 and 0.05 mM K+ AtHAK5 and AtAKT1 are the only contributors to K+ acquisition. At higher K+ concentrations, unknown systems come into operation and participate together with AtAKT1 in low-affinity K+ uptake.
CIPK23 directly phosphorylates the K+ transporter AKT1
Data show that interacting calcium sensors (CBL1 and CBL9) together with CIPK23, but not either alone, activated the AKT1 channel in a Ca(2 (show CA2 ELISA Kits)+)-dependent manner, connecting the Ca(2 (show CA2 ELISA Kits)+) signal to K(+) uptake through activation of a K(+) channel (show KCNC4 ELISA Kits).
the LIN-28/let-7/AKT/DAF-16 axis is a program that plays an important role in balancing reproduction and somatic maintenance.
this study shows that akt-1 and akt-2 negatively regulate DNA-damage-induced apoptosis in the C. elegans germline and the antiapoptotic activity of akt-1 is independent of its target gene daf-16 but dependent on cep-1/p53 (show TP53 ELISA Kits).
Modulation of pptr-1 affects insulin (show INS ELISA Kits)/IGF-1 (show IGF1 ELISA Kits) signaling pathway-associated phenotypes including life span, dauer, stress resistance, and fat storage; study shows that PPTR-1 functions by regulating worm AKT-1 phosphorylation at Thr (show TRH ELISA Kits) 350.
Exogenous AKT was transcribed, and AKT was overexpressed, inducing the phosphorylation of p70S6K (show RPS6KB1 ELISA Kits) (Thr389) and 4E-BP1 (show EIF4EBP1 ELISA Kits) (Thr37/46) in goat fetal fibroblasts.
findings suggested that the expressions of the cardiac CACNA1C (show CACNA1C ELISA Kits) were under the CLOCK-BMAL1 (show ARNTL ELISA Kits) regulation, probably through the PI3K-Akt signal pathway
Overexpression of human Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish.
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
, RAC-alpha serine/threonine-protein kinase
, protein kinase B alpha
, proto-oncogene c-Akt
, rac protein kinase alpha
, AKT1 kinase
, protein kinase B-alpha
, proto-oncogene c-AKT
, related to A and C kinases
, actin, cytoplasmic 1
, Akt kinase
, dAkt kinase
, protein kinase B
, related to PKA to PKC protein kinases
, related to the A and C kinases
, 5C actin
, actin 5 C
, actin 5C
, actin 5c
, actin A1
, cellular cytoskeletal beta-actin
, gamma non-muscle actin
, beta actin
, RAC protein kinase alpha RAC-PK alpha
, murine thymoma viral (v-akt) oncogene homolog 1
, thymoma viral proto-oncogene 1
, v-akt murine thymoma viral oncogene-like protein 1
, serine/threonine protein kinase
, protein kinase Akt-1
, protein kinase B, alpha
, v-akt murine thymoma viral oncogene homolog 1
, v-akt murine thymoma viral oncogene-like 1