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Association between insulin (show INS Proteins) sensitivity and genetic variants in DEPTOR gene suggest DEPTOR and mammalian target of rapamycin (show FRAP1 Proteins) signaling pathway to be potential target for future research and pharmacological interventions.
High DEPTOR expression is associated with T-cell leukemia.
Results provide evidence that DEPTOR acts as a tumor suppressor by limiting EGFR (show EGFR Proteins)-driven lung adenocarcinoma progression.
that DEPTOR expression is required to maintain myeloma cell differentiation and high level of its expression are associated with better outcome.
High expression of DEPTOR benefits esophageal squamous cell carcinoma patients in early stage but not advanced stage.
the present findings supported the fact that DEPTOR-mTOR (show FRAP1 Proteins) signaling is a central regulator of lipid metabolism-mediated inflammation in lymphocytes of PBMC culture.
In this study we began by validating the expression of four main mTOR (show FRAP1 Proteins) pathway components, mTOR (show FRAP1 Proteins), DEPTOR, rictor and raptor (show RPTOR Proteins), at gene and protein level in in vitro models of endometrioid (MDAH2774) and clear cell (SKOV3) ovarian cancer
Cul1 (show CUL1 Proteins) promoted mTORC1 activity and cap-dependent translation by enhancing the ubiquitination and degradation of DEPTOR.
Propose regulation of placental SNAT2 (show SLC38A2 Proteins)/LAT1 (show LAT Proteins) ubiquitination by mTORC1 and Nedd4-2 (show NEDD4L Proteins).
Deptor enhances triple-negative breast cancer metastasis and chemoresistance through coupling to survivin (show BIRC5 Proteins) expression
These results support the idea that other neuronal populations are responsible for these phenotypes. Nonetheless, we observed a mild elevation in fasting blood glucose, insulin (show INS Proteins) resistance, and alterations in liver glucose and lipid homeostasis in mice overexpressing DEPTOR in POMC (show POMC Proteins) neurons. Taken together, these results show that DEPTOR overexpression in POMC (show POMC Proteins) neurons does not affect energy balance regulation but could modu
The present study indicates that regulation of DEPTOR/mTOR (show FRAP1 Proteins) signaling may be an important mechanism for glutamine (show GFPT1 Proteins) in prevention against the development of colitis-associated colorectal cancer (CAC (show SLC25A20 Proteins)): the chemopreventive effect of dietary glutamine (show GFPT1 Proteins) on CAC (show SLC25A20 Proteins) is, at least in part, associated with the induction of autophagy.
DEPTOR regulates liver inflammation at least partially via mTORC1 pathway, and is down-regulated by lypopolysaccharides through p65 (show NFkBP65 Proteins).
p38gamma (show MAPK12 Proteins) and p38delta control heart growth by modulating mTOR (show FRAP1 Proteins) pathway through DEPTOR phosphorylation and subsequent degradation.
DEPTOR plays a key role in maintaining stem cell pluripotency by limiting mTOR (show FRAP1 Proteins) activity in undifferentiated embryonic stem cells
DEPTOR is induced by glucocorticoids during adipogenesis and that its overexpression promotes, while its suppression blocks, adipogenesis.
Data show that knockdown reduced Deptor mRNA and protein content by 90%, which increased phosphorylation of mTOR (show FRAP1 Proteins) kinase substrates, 4E-BP1 (show EIF4EBP1 Proteins) and S6K1 (show RPS6KB1 Proteins), and concomitantly increased protein synthesis.
Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes (By similarity).
DEP domain containing MTOR-interacting protein
, DEP domain containing 6
, DEP domain containing mTOR interacting protein
, DEP domain-containing mTOR-interacting protein
, DEP domain-containing protein 6
, Rap guanine nucleotide exchange factor (GEF) 4