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anti-Human GRIA1 Antibodies:
anti-Rat (Rattus) GRIA1 Antibodies:
anti-Mouse (Murine) GRIA1 Antibodies:
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Rat (Rattus) Polyclonal GRIA1 Primary Antibody for IHC, WB - ABIN361477
Sears, Liu, Narayanan, Sharf, Yeckel, Laubach, Aghajanian, DiLeone: Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Show all 27 Pubmed References
Rat (Rattus) Polyclonal GRIA1 Primary Antibody for WB - ABIN361476
Ferrario, Loweth, Milovanovic, Wang, Wolf: Distribution of AMPA receptor subunits and TARPs in synaptic and extrasynaptic membranes of the adult rat nucleus accumbens. in Neuroscience letters 2011
Show all 13 Pubmed References
Chicken Polyclonal GRIA1 Primary Antibody for WB - ABIN2473830
Castellani, Quinlan, Cooper, Shouval: A biophysical model of bidirectional synaptic plasticity: dependence on AMPA and NMDA receptors. in Proceedings of the National Academy of Sciences of the United States of America 2001
Rat (Rattus) Polyclonal GRIA1 Primary Antibody for WB - ABIN1741837
Song, Massenburg, Wenderski, Jayaraman, Thompson, Neves: ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion. in Proceedings of the National Academy of Sciences of the United States of America 2013
Mouse (Murine) Polyclonal GRIA1 Primary Antibody for IHC (fro), IHC - ABIN152516
Kim, Kwon, Kim, Josselyn, Han: Memory recall and modifications by activating neurons with elevated CREB. in Nature neuroscience 2013
These findings indicate that the CaMKII (show CAMK2G Antibodies)-mediated GluA1 phosphorylation of S567 and S831 is critical for P2X2 (show P2RX2 Antibodies)-mediated AMPAR internalization and ATP-driven synaptic depression.
The reversible binding of kynurenic acid (KYNA) on human glutamate receptor (GluR1) polypeptide (GluR1270-300)-modified gold surface has been studied at various temperatures under physiological conditions by two-dimensional SPR (show SPR Antibodies) experiments. The registered sensorgrams were fitted by using different kinetic models without application of any commercial software. Results suggested that the binding reaction was exothermic.
Elevated GluA1 expression in spinal cord of the amyotrophic lateral sclerosis patients.
This study demonstrated that a significant decrease in the protein level of GluA1 in major depression disorder.
The findings do not support the association of GRIA1 SNPs with schizophrenia in the Chinese Han population.
Our data of this study confirmed the association of GRIA1 (rs2195450) to female migraine susceptibility in the Chinese Han population.
Polymorphisms in GRIA1 gene are a risk factor for asparaginase hypersensitivity during the treatment of childhood acute lymphoblastic leukemia
The level of phosphorylated GluA1 at S831 and S845, two major sites implicated in AMPAR regulation, is almost negligible. Results impel us to reconsider the mechanisms underlying synaptic plasticity.
This study failed to replicate previously reported association between GRIA1 rs548294 and migraine without aura (show AURKA Antibodies), either as single marker or when analyzed in haplotype combination with rs2195450.
the levels were comparable for complexes containing GluR2 (show GRIA2 Antibodies), GluR3 (show GRIA3 Antibodies) and GluR4 (show GRIA4 Antibodies) as well as 5-HT1A (show HTR1A Antibodies). Moreover, the levels of complexes containing muscarinic AChR M1, NR1 (show GRIN1 Antibodies) and GluR1 were significantly increased in male patients with AD.
Data indicate a key role of FoxO3a (show FOXO3 Antibodies)/Zdhhc3 (show ZDHHC3 Antibodies)/GluA1 axis in the high-fat diet (HFD)-dependent impairment of cognitive function.
translocation of surface GluA1, but not GluA2 (show GRIA2 Antibodies), AMPAR subunits to the synapse requires the amino-terminal domain
Taken together, these results suggest that ApoE4 enhances Abeta (show APP Antibodies) inhibition of insulin (show INS Antibodies)-stimulated AMPA (show GRIA3 Antibodies) receptor function, which accelerates memory impairment in ApoE4xAPP mice.
Both hippocampal as well as extra-hippocampal GluA1-containing AMPA (show GRIA3 Antibodies) receptors contribute to spatial working memory.
Presynaptic (CA3 (show CA3 Antibodies) pyramidal cell), but not postsynaptic (CA1 (show CA1 Antibodies) pyramidal cell), deletion of N-methyl-d-aspartate (NMDA)-type glutamate (show GRIN1 Antibodies) receptors eliminated the ketamine-induced enhancement of excitatory synaptic transmission in hippocampal slices and the antidepressant actions of ketamine
In the present study, by combining a 64-channel multielectrode system and a novel analysis and visualization method, we observed the accurate spatial localization and dynamic temporal changes of network fEPSP signals and LTP responses within the ACC circuit and found that PKA phosphorylation, but not PKC phosphorylation, of the GluA1 is required for LTP in the ACC.
Data suggest that phosphorylation of Shp2/Ptpn11 (show PTPN11 Antibodies) at Tyr542 and its translocation to postsynaptic compartment are integral processes in synaptic scaling/homeostasis; Shp2 (show PTPN11 Antibodies) phosphatase activity is critical to regulation of Ser (show SIGLEC1 Antibodies)(P)845 GluA1 and surface expression of GluA1 during synaptic scaling. (Shp2/Ptpn11 (show PTPN11 Antibodies) = protein tyrosine phosphatase non-receptor type 11 (show PTPN11 Antibodies); GluA1 = glutamate receptor ionotropic Ampa1 [alpha 1])
Gria1 expression in Purkinje cells is not required for cerebellar motor learning.
Three epilepsy-associated missense mutations reduce neural precursor cell expressed developmentally down-regulated gene 4 (show NEDD4 Antibodies)-2 (Nedd4-2 (show NEDD4L Antibodies))-mediated AMPA (show GRIA3 Antibodies) receptor GluA1 ubiquitination.
Chronic stress-elicited depressive behavior may be due to hypertrophy of basolateral amygdala (BLA (show LACTB Antibodies)) neuronal dendrites and increased of Glur1-Glur2 (show GRIA2 Antibodies) ratio in BLA (show LACTB Antibodies) neurons.
the intracellularly located CTD of GLUR1 is the origin of TARP (show TARP Antibodies)-specific functional modulation and not merely a facilitator of trafficking
We also assessed ionotropic glutamate (show GRIN2A Antibodies) receptor GLR-1 cell-specifically within AIB and determined that GLR-1 fine-tunes AIB activity to modify locomotion following reversal events. Our research highlights that signal integration underlying the initiation and fine-tuning of backwards locomotion is AIB and NPR (show NPTXR Antibodies)-9 dependent, and has demonstrated the suitability of C. elegans for analysis of multisensory integration
We propose a model in which synaptic activity regulates the nuclear localization of CMK-1 to mediate a negative feedback mechanism coupling GLR-1 activity with its own transcription.
Mutants lacking p38 MAPK (show MAPK14 Antibodies) components pmk (show PMVK Antibodies)-1 or sek-1 (show MAP2K4 Antibodies) resemble mutants lacking the hypoxia response component and prolyl hydroxylase egl-9, with impaired subcellular localization of Mint (show SPEN Antibodies) orthologue LIN-10, internalization of glutamate (show GRIN2A Antibodies) receptor GLR-1, and depression of GLR-1-mediated behaviors.
KEL-8 is a substrate receptor for Cullin 3 ubiquitin ligases that is required for the proteolysis of GLR-1 receptors and suggest a novel postmitotic role in neurons for Kelch/CUL3 ubiquitin ligases.
WDR-20 and WDR-48 form a complex with USP-46 and stimulate the DUB to deubiquitinate and stabilize GLR-1 in vivo.
glr-1 is required for long-term memory for habituation and memory for context conditioning.
Study indicates kinesin KLP (show KIF1B Antibodies)-4 as a novel regulator of anterograde GLR-1 glutamate (show GRIN2A Antibodies) receptors trafficking and reveals a cellular control mechanism by which receptor cargo is targeted for degradation in tje absence of its motor.
An auxiliary protein SOL (show KALRN Antibodies)-2, a CUB-domain protein, associates with both the related auxiliary subunit SOL-1 and with the GLR-1 AMPA (show GRIA3 Antibodies) receptor.
UEV-1 could regulate a small subset of K63-linked ubiquitination events in nematodes, at least one of which is critical in regulating GLR-1 trafficking
Long-term memory in C. elegans is dependent on glr-1 and likely involves changes in the expression or localization of glutamate (show GRIN2A Antibodies) receptors
The GRIA1 polymorphism exists in beef cows but it does not influence antral follicle numbers. The association between GnRHR (show GNRHR Antibodies) genotype and age at first calving is likely not causal as this polymorphism is not functional.
Data show that GRIA1 is a critical mediator of ovulation and that GRIA1 might be a useful target for reproductive therapy.
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, AMPA-selective glutamate receptor 1
, glutamate receptor 1
, glutamate receptor A
, glutamate receptor subunit GluR1
, glutamate receptor, ionotropic, AMPA1 (alpha 1)
, glutamate receptor ionotropic, AMPA 1
, AMPA glutamate receptor
, glutamate receptor, ionotropic, AMPA 1
, GluR1 protein
, glutamate receptor, ionotropic, AMPA 1.2
, glutamate receptor, ionotropic, AMPA 1b
, AMPA receptor subunit GluR1A
, glutamate receptor, ionotropic, AMPA1.1
, ionotropic glutamate receptor AMPA 1