Browse our anti-MTOR (FRAP1) Antibodies

Horse (Equine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

Human Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

1. Studies indicate that understanding mTOR network circuitry will provide insight into its deregulation in diabetes, cancer, and cardiovascular disease, but modeling in silico to elucidate how insulin (show INS Antibodies) activates mTORC2 (show CRTC2 Antibodies) remains poorly defined.

2. these findings uncover a novel mechanism by which PML (show PML Antibodies) loss may contribute to mTOR activation and cancer progression via dysregulation of basal DDIT4 (show DDIT4 Antibodies) gene expression.

3. High mTOR expression is associated with periodontitis.

4. This review intends to provide an outline of the principal biological and molecular functions of mTOR.

5. High mTOR expression is associated with Pancreatic Ductal Adenocarcinoma Metastasis.

6. High mTOR expression is associated with prostate cancer.

7. In ASS1 (show ASS1 Antibodies)-knockout cells, DEPTOR (show DEPTOR Antibodies), an inhibitor of mTORC1 signal, was downregulated and mTORC1 signaling was more activated in response to arginine.

8. This review addresses the role of mTOR-dependent autophagy dysfunction in a variety of neuropsychiatric disorders, to focus mainly on psychiatric syndromes including schizophrenia and drug addiction. [review]

9. This article reviews the role of mTOR in cellular processes involved in cancer cachexia and highlights the studies supporting the contribution of mTOR in cancer cachexia. [review]

10. High mTOR expression is associated with aggressive pathology in urologic cancers.

Mouse (Murine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

1. metabolic profiling reveals elevated glycolysis and increased mTORC1 signaling in Ndfip1 (show NDFIP1 Antibodies)-deficient Treg cells

2. Sesn2 (show SESN2 Antibodies)/AMPK (show PRKAA1 Antibodies)/mTOR signaling mediates balance between survival and apoptosis in sensory hair cells under stress.

3. mTOR is a direct interacting partner of Trx1 (show TXN Antibodies) in the heart. Trx1 (show TXN Antibodies) protects cardiomyocytes against oxidative stress by reducing mTOR at Cys (show DNAJC5 Antibodies)-1483, thereby preserving the activity of mTOR and inhibiting cell death.

4. the present study suggested that Pulsed electromagnetic fields (PEMFs) reduced osteoclast formation from RAW264.7 macrophages via inhibition of the Akt (show AKT1 Antibodies)/mTOR signaling pathway. These findings provided novel insight into the mechanisms through which PEMFs suppress osteoclast differentiation.

5. mTOR signaling is a key mediator of central insulin (show INS Antibodies) dysfunction, which leads to pathogenesis of Alzheimer disease.

6. Results indicate that L-Arg stimulates protein synthesis via the activation of the mTOR (Thr (show TRH Antibodies) 2446)/p70S6K (show RPS6KB1 Antibodies) signaling pathway in an NO-dependent manner.

7. High mTOR expression is associated with cardiac hypertrophy.

8. cPKC&-gamma modulated sequential reactivation of mTOR inhibited autophagic flux in neurons exposed to OGD (show FGFR1 Antibodies)/R, which may provide endogenous interventional strategies for stroke, especially ischemia/reperfusion injury

9. findings suggest that deficiencies of leucine and isoleucine reduce type I and III tropocollagen syntheses in skin by suppressing the action of mTOR

10. MTOR-dependent pathways in primordial or growing oocytes differentially affected downstream processes including follicular development, sex-specific identity of early granulosa cells, maintenance of oocyte genome integrity, oocyte gene expression, meiosis, and preimplantation developmental competence.

Zebrafish Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

1. This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (show ESCO2 Antibodies) cells and supports that normal gene expression and translation requires ESCO2 (show ESCO2 Antibodies) function.

2. By inhibiting mTOR signaling via Fbxw7 (show FBXW7 Antibodies), the amount of myelination during development is reduced.

3. Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish

4. In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (show TP53 Antibodies).

5. TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.

6. in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine

Pig (Porcine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

1. The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg (show PPARG Antibodies). In summary, PPARg (show PPARG Antibodies) plays an important role in the regulation of IGF-1 (show IGF1 Antibodies) secretion and gene expression in response to dietary protein.

2. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt (show AKT1 Antibodies)-mTOR-FOXO1 (show FOXO1 Antibodies) signaling and suppressing the activation of TLR4 (show TLR4 Antibodies) and/or NOD2 (show NOD2 Antibodies) signaling pathways.

3. Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).

4. AMPK (show PRKAA1 Antibodies)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.

5. Uroguanylin (show GUCA2B Antibodies) modulates (Na++K+)ATPase (show ATP1A1 Antibodies) in a proximal tubule cells via cGMP/protein kinase (show CDK7 Antibodies) G, cAMP/protein kinase A, and mTOR pathways.

6. mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (show CCND1 Antibodies), and CCNE1 (show CCNE1 Antibodies).

7. L-Glutamine (show GFPT2 Antibodies) enhances enterocyte growth via activation of the mTOR.

8. Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr (show PTCHD3 Antibodies) cells through activation of the MTOR-RPS6K-RPS6 (show RPS6 Antibodies)-EIF4EBP1 (show EIF4EBP1 Antibodies) signal transduction pathway.

9. Data indicate that the expression of MAP1LC3A (show MAP1LC3A Antibodies), B and autophagy-associated genes (ATG5 (show ATG5 Antibodies), mTOR, Beclin-1 (show BECN1 Antibodies)) was increased in normal pigs, while decreased in miniature pigs.

10. Biochemical, cellular, and molecular data suggest that L-arginine (show GATM Antibodies) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.

Cow (Bovine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

1. AnxA2 (show ANXA2 Antibodies) functions as a critical regulator for amino acid or hormone-induced milk synthesis and mammary gland epithelial cell proliferation via the PI3K-mTOR-SREBP-1c (show SREBF1 Antibodies)/Cyclin D1 (show CCND1 Antibodies) signaling pathway.

2. These findings suggest that mTOR is involved in the control of the expression of multiple genes in cattle, which may be triggered by the luteinizing hormone surge.

3. 14-3-3gamma affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.

4. Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (show JAK2 Antibodies)-STAT5 (show STAT5A Antibodies) and mTOR signaling pathways.

5. Insulin (show INS Antibodies)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.

6. IGF-I (show IGF1 Antibodies) down-regulated functional IGF-I receptor (show IGF1R Antibodies) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (show IGF1R Antibodies) level in nonstimulated cells.

7. stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (show INS Antibodies), and prolactin (show PRL Antibodies) were associated with increased phosphorylation of the mTOR substrates

8. data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

9. prostaglandin F2alpha phosphorylates TSC2 (show TSC2 Antibodies) and activates mTOR and ribosomal protein S6 (show RPS6 Antibodies) kinase (show RPS6KB1 Antibodies) signaling in an AKT (show AKT1 Antibodies)-independent manner

10. mTOR links IGF-I (show IGF1 Antibodies) and EGF (show EGF Antibodies) signaling in inhibiting the autophagy pathways.