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anti-Human MTOR Antibodies:
anti-Mouse (Murine) MTOR Antibodies:
anti-Rat (Rattus) MTOR Antibodies:
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Fish Polyclonal MTOR Primary Antibody for ELISA, IHC - ABIN6255124
Liu, Luo, Mu, Liu, Geng, Liu, Yi: Fluoxetine regulates mTOR signalling in a region-dependent manner in depression-like mice. in Scientific reports 2016
Show all 12 Pubmed References
Fish Polyclonal MTOR Primary Antibody for ELISA, ICC - ABIN6263424
He, Cao, Guo, Li, Shang, Liu, Xie, Xu, Liu: Quercetin induces autophagy via FOXO1-dependent pathways and autophagy suppression enhances quercetin-induced apoptosis in PASMCs in hypoxia. in Free radical biology & medicine 2017
Show all 7 Pubmed References
Human Polyclonal MTOR Primary Antibody for IF (p), IHC (p) - ABIN676403
Li, Liu, Wang, Sun, Ding, Sun, Han, Wang: Follistatin could promote the proliferation of duck primary myoblasts by activating PI3K/Akt/mTOR signalling. in Bioscience reports 2014
Show all 6 Pubmed References
Human Polyclonal MTOR Primary Antibody for ELISA, EM - ABIN153493
Gupta, Dillon, Ziesmer, Feldman, Witzig, Ansell, Cerhan, Novak: A proliferation-inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase-regulated mammalian target of rapamycin activation. in Blood 2009
Show all 5 Pubmed References
Human Polyclonal MTOR Primary Antibody for DB - ABIN1881353
Dowling, Zakikhani, Fantus, Pollak, Sonenberg: Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. in Cancer research 2007
Show all 4 Pubmed References
Human Polyclonal MTOR Primary Antibody for ICC, IF - ABIN151707
Bolster, Vary, Kimball, Jefferson: Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation. in The Journal of nutrition 2004
Show all 4 Pubmed References
Human Polyclonal MTOR Primary Antibody for IHC (p), WB - ABIN272127
Li, Yan, Zhang, Jiang, Sun, Hu, Sun, Xu: miR-145 inhibits isoproterenol-induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6. in FEBS letters 2013
Show all 3 Pubmed References
Human MTOR Primary Antibody for IHC - ABIN966602
Holz, Blenis: Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. in The Journal of biological chemistry 2005
Show all 3 Pubmed References
Human Polyclonal MTOR Primary Antibody for IF, IHC (p) - ABIN390217
Cao, Dong, Meng, Liu, Liao, Liu: MiR-511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3. in Tumour biology 2015
Show all 3 Pubmed References
Human Polyclonal MTOR Primary Antibody for IF (p), IHC (p) - ABIN747158
Yang, Wang, Wang, Zhang, Zhang, Lu, Wang: mTOR is involved in 17?-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1, and CCNE1. in Molecular reproduction and development 2015
Show all 2 Pubmed References
Studies indicate that understanding mTOR network circuitry will provide insight into its deregulation in diabetes, cancer, and cardiovascular disease, but modeling in silico to elucidate how insulin (show INS Antibodies) activates mTORC2 (show CRTC2 Antibodies) remains poorly defined.
RIO kinase 3 (RIOK3 (show RIOK3 Antibodies)) positively regulates the activity of the AKT (show AKT1 Antibodies)/mTOR pathway in glioma cells.
Targeted profiling of RNA translation reveals mTOR-4EBP1 (show EIF4EBP1 Antibodies)/2-independent translation regulation of mRNAs encoding ribosomal proteins.
Results show that mTOR expression is regulated by PPP2R2D which influences its protein phosphorylation level contributing to gastric cancer progression.
We performed quantitative mass spectrometry of IAV1918-infected cells to measure host protein dysregulation. Selected proteins were validated by immunoblotting and phosphorylation levels of members of the PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies)/mTOR pathway were assessed.
Using an mTORspecific signalling pathway phospho array we revealed that NVPBEZ235 significantly decreased phosphorylation of 4EBP1 (show EIF4EBP1 Antibodies) (Thr70), the downstream target of mTORC1.
The essential role of mTOR in the endocrine therapy resistance in estrogen receptor (show ESR1 Antibodies)-positive, HER2 (show ERBB2 Antibodies)-negative breast cancer.[review]
MiR (show MLXIP Antibodies)-206 inhibits the development of epithelial ovarian cancer cell by directly targeting c-Met and inhibiting the c-Met/AKT (show AKT1 Antibodies)/mTOR signaling pathway.
our findings identified LSD1 (show KDM1A Antibodies) as a novel negative regulator of autophagy through the mTOR signaling pathway in ovarian cancer HO8910 cells and indicated that LSD1 (show KDM1A Antibodies) may function as a driving factor of ovarian cancer progression via deregulating autophagy.
These results suggested that silibinin induced glioblastoma cell apoptosis concomitant with autophagy which might be due to simultaneous inhibition of mTOR and YAP (show YAP1 Antibodies) and silibinin induced autophagy exerted a protective role against cell apoptosis in both A172 and SR cells.
the present study suggested that Pulsed electromagnetic fields (PEMFs) reduced osteoclast formation from RAW264.7 macrophages via inhibition of the Akt (show AKT1 Antibodies)/mTOR signaling pathway. These findings provided novel insight into the mechanisms through which PEMFs suppress osteoclast differentiation.
mTOR signaling is a key mediator of central insulin (show INS Antibodies) dysfunction, which leads to pathogenesis of Alzheimer disease.
Results indicate that L-Arg stimulates protein synthesis via the activation of the mTOR (Thr (show TRH Antibodies) 2446)/p70S6K (show RPS6KB1 Antibodies) signaling pathway in an NO-dependent manner.
High mTOR expression is associated with cardiac hypertrophy.
cPKC&-gamma modulated sequential reactivation of mTOR inhibited autophagic flux in neurons exposed to OGD (show FGFR1 Antibodies)/R, which may provide endogenous interventional strategies for stroke, especially ischemia/reperfusion injury
findings suggest that deficiencies of leucine and isoleucine reduce type I and III tropocollagen syntheses in skin by suppressing the action of mTOR
MTOR-dependent pathways in primordial or growing oocytes differentially affected downstream processes including follicular development, sex-specific identity of early granulosa cells, maintenance of oocyte genome integrity, oocyte gene expression, meiosis, and preimplantation developmental competence.
The control of cMaf (show MAF Antibodies) expression at the translational level by mTOR regulated the expression of inflammatory genes in response to lipopolysaccharide challenge.
The function of mTOR in epidermal morphogenesis is split between mTORC1 and mTORC2 (show CRTC2 Antibodies). Whereas mTORC1 mainly controls keratinocyte proliferation within the basal layer, early epidermal stratification and differentiation, mTORC2 (show CRTC2 Antibodies) primarily controls cell division orientation and late stage barrier formation of the interfollicular epidermis.
Loss of mTOR in vasoactive intestinal peptide (show Vip Antibodies) neurons displayed erratic circadian behavior and weakened synchronization among cells in the suprachiasmatic nucleus, the master circadian pacemaker.
This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (show ESCO2 Antibodies) cells and supports that normal gene expression and translation requires ESCO2 (show ESCO2 Antibodies) function.
By inhibiting mTOR signaling via Fbxw7 (show FBXW7 Antibodies), the amount of myelination during development is reduced.
Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish
In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (show TP53 Antibodies).
TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.
in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg (show PPARG Antibodies). In summary, PPARg (show PPARG Antibodies) plays an important role in the regulation of IGF-1 (show IGF1 Antibodies) secretion and gene expression in response to dietary protein.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt (show AKT1 Antibodies)-mTOR-FOXO1 (show FOXO1 Antibodies) signaling and suppressing the activation of TLR4 (show TLR4 Antibodies) and/or NOD2 (show NOD2 Antibodies) signaling pathways.
Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).
AMPK (show PRKAA1 Antibodies)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Uroguanylin (show GUCA2B Antibodies) modulates (Na++K+)ATPase (show ATP1A1 Antibodies) in a proximal tubule cells via cGMP/protein kinase (show CDK7 Antibodies) G, cAMP/protein kinase A, and mTOR pathways.
mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (show CCND1 Antibodies), and CCNE1 (show CCNE1 Antibodies).
L-Glutamine (show GFPT2 Antibodies) enhances enterocyte growth via activation of the mTOR.
Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr (show PTCHD3 Antibodies) cells through activation of the MTOR-RPS6K-RPS6 (show RPS6 Antibodies)-EIF4EBP1 (show EIF4EBP1 Antibodies) signal transduction pathway.
Data indicate that the expression of MAP1LC3A (show MAP1LC3A Antibodies), B and autophagy-associated genes (ATG5 (show ATG5 Antibodies), mTOR, Beclin-1 (show BECN1 Antibodies)) was increased in normal pigs, while decreased in miniature pigs.
Biochemical, cellular, and molecular data suggest that L-arginine (show GATM Antibodies) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.
AnxA2 (show ANXA2 Antibodies) functions as a critical regulator for amino acid or hormone-induced milk synthesis and mammary gland epithelial cell proliferation via the PI3K-mTOR-SREBP-1c (show SREBF1 Antibodies)/Cyclin D1 (show CCND1 Antibodies) signaling pathway.
These findings suggest that mTOR is involved in the control of the expression of multiple genes in cattle, which may be triggered by the luteinizing hormone surge.
14-3-3gamma affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (show JAK2 Antibodies)-STAT5 (show STAT5A Antibodies) and mTOR signaling pathways.
Insulin (show INS Antibodies)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.
IGF-I (show IGF1 Antibodies) down-regulated functional IGF-I receptor (show IGF1R Antibodies) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (show IGF1R Antibodies) level in nonstimulated cells.
stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (show INS Antibodies), and prolactin (show PRL Antibodies) were associated with increased phosphorylation of the mTOR substrates
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
prostaglandin F2alpha phosphorylates TSC2 (show TSC2 Antibodies) and activates mTOR and ribosomal protein S6 (show RPS6 Antibodies) kinase (show RPS6KB1 Antibodies) signaling in an AKT (show AKT1 Antibodies)-independent manner
mTOR links IGF-I (show IGF1 Antibodies) and EGF (show EGF Antibodies) signaling in inhibiting the autophagy pathways.
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
FK506 binding protein 12-rapamycin associated protein 1
, FK506 binding protein 12-rapamycin associated protein 2
, FK506-binding protein 12-rapamycin complex-associated protein 1
, FKBP-rapamycin associated protein
, FKBP12-rapamycin complex-associated protein 1
, mammalian target of rapamycin
, rapamycin and FKBP12 target 1
, rapamycin associated protein FRAP2
, rapamycin target protein 1
, serine/threonine-protein kinase mTOR
, FKBP-rapamycin associated protein (FRAP)
, FKBP-rapamycin-associated protein FRAP
, FKBP12-rapamycin complex-associated protein
, angiopoietin-like factor CDT6
, rapamycin and FKBP12 target-1 protein
, target of rapamycin