Browse our anti-MTOR (FRAP1) Antibodies

Horse (Equine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

Human Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

1. the DAPK (show DAPK1 Antibodies)-mTOR pathway is critical for anti-HCV effects of peg (show PAEP Antibodies)-IFN-alpha (show IFNA Antibodies)

2. Studies indicate that understanding mTOR network circuitry will provide insight into its deregulation in diabetes, cancer, and cardiovascular disease, but modeling in silico to elucidate how insulin (show INS Antibodies) activates mTORC2 (show CRTC2 Antibodies) remains poorly defined.

3. Preventive function of Sirt1 (show SIRT1 Antibodies) may be the inhibition of mTOR phosphorylation, whereas mTOR activity was shown to be a pathogenic culprit of systemic sclerosis in the current research.

4. High expression of periostin (show POSTN Antibodies) and mTOR were independent risk factors of esophageal squamous cell carcinoma patients.

5. the Nav1.6 (show SCN8A Antibodies) sodium channel promotes cell proliferation and invasion through mTOR-mediated Na+/Ca2 (show CA2 Antibodies)+ exchange in melanoma.

6. HER2 (show ERBB2 Antibodies)(+) and triple-negative breast cancer cell lines were treated with AR antagonist plus anti-HER2 (show ERBB2 Antibodies) mAb trastuzumab or mTOR inhibitor everolimus..AR antagonists synergize with FDA-approved breast cancer therapies such as everolimus and trastuzumab through distinct mechanisms. Treatment combinations are effective in trastuzumab-resistant HER2 (show ERBB2 Antibodies)(+) breast cancer cells in vivo

7. Mtor expression is regulated by PRSS8 (show PRSS8 Antibodies) in glioma.

8. Autophagy regulates c-MET phosphorylation via an mTORC2 (show CRTC2 Antibodies)-dependent mechanism.

9. important roles for mTOR in promoting the differentiation of adult stem cells, driving the growth and proliferation of stem and progenitor cells, and dictating the differentiation program of multipotent stem cell populations.

10. The mechanism for Fluoxetine-induced autophagic cell death was associated with inhibition of eEF2K (show EEF2K Antibodies) and activation of AMPK (show PRKAA1 Antibodies)-mTOR-ULK complex axis.

Mouse (Murine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

1. findings suggested E. faecalis LTA (show LTA Antibodies) may increased macrophages autophagy via inhibiting PI3K/Akt (show AKT1 Antibodies)/mTOR pathway and this process was Beclin1 (show BECN1 Antibodies) dependent.

2. Preventive function of Sirt1 (show SIRT1 Antibodies) may be the inhibition of mTOR phosphorylation, whereas mTOR activity was shown to be a pathogenic culprit of systemic sclerosis in the current research.

3. CRP (show CRP Antibodies) is pathogenic in type-2 diabetes (T2DN). CRP (show CRP Antibodies) may promote CD32b- NF-kappaB (show NFKB1 Antibodies) signaling to mediate renal inflammation; whereas, CRP (show CRP Antibodies) may enhance renal fibrosis in T2DN via CD32b-Smad3 (show SMAD3 Antibodies)-mTOR signaling.

4. These results reveal a novel role of miR (show MLXIP Antibodies)-199a as a key regulator of cardiac autophagy.

5. An FAK (show PTK2 Antibodies)-YAP (show YAP1 Antibodies)-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice.

6. Our results suggest that mTORC1/mTORC2 (show CRTC2 Antibodies) dual inhibition is more effective for anti-angiogenic therapy, as it impairs not only endothelial cell proliferation, but also endothelial cell elongation.

7. These results reveal that MTOR is dispensable for the maintenance of undifferentiated spermatogonia, but is cell autonomously required for their proliferation and differentiation.

8. mTOR mediates metabolic adaptation of antigen-presenting cells in distinct tissues, influencing the immunological character of allergic inflammation.

9. mTOR Inhibition Subdues Milk Disorder Caused by Maternal VLDLR (show VLDLR Antibodies) Loss

10. AKAP1 (show AKAP1 Antibodies) is a transcriptional target of Myc (show MYC Antibodies), and it supports mTOR pathway and the growth of cancer cells.

Zebrafish Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

1. This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (show ESCO2 Antibodies) cells and supports that normal gene expression and translation requires ESCO2 (show ESCO2 Antibodies) function.

2. By inhibiting mTOR signaling via Fbxw7 (show FBXW7 Antibodies), the amount of myelination during development is reduced.

3. Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish

4. In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (show TP53 Antibodies).

5. TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.

6. in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine

Pig (Porcine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

1. The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg (show PPARG Antibodies). In summary, PPARg (show PPARG Antibodies) plays an important role in the regulation of IGF-1 (show IGF1 Antibodies) secretion and gene expression in response to dietary protein.

2. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt (show AKT1 Antibodies)-mTOR-FOXO1 (show FOXO1 Antibodies) signaling and suppressing the activation of TLR4 (show TLR4 Antibodies) and/or NOD2 (show NOD2 Antibodies) signaling pathways.

3. Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).

4. AMPK (show PRKAA1 Antibodies)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.

5. Uroguanylin (show GUCA2B Antibodies) modulates (Na++K+)ATPase (show ATP1A1 Antibodies) in a proximal tubule cells via cGMP/protein kinase (show CDK7 Antibodies) G, cAMP/protein kinase A, and mTOR pathways.

6. mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (show CCND1 Antibodies), and CCNE1 (show CCNE1 Antibodies).

7. L-Glutamine (show GFPT2 Antibodies) enhances enterocyte growth via activation of the mTOR.

8. Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr (show PTCHD3 Antibodies) cells through activation of the MTOR-RPS6K-RPS6 (show RPS6 Antibodies)-EIF4EBP1 (show EIF4EBP1 Antibodies) signal transduction pathway.

9. Data indicate that the expression of MAP1LC3A (show MAP1LC3A Antibodies), B and autophagy-associated genes (ATG5 (show ATG5 Antibodies), mTOR, Beclin-1 (show BECN1 Antibodies)) was increased in normal pigs, while decreased in miniature pigs.

10. Biochemical, cellular, and molecular data suggest that L-arginine (show GATM Antibodies) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.

Cow (Bovine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

1. AnxA2 (show ANXA2 Antibodies) functions as a critical regulator for amino acid or hormone-induced milk synthesis and mammary gland epithelial cell proliferation via the PI3K-mTOR-SREBP-1c (show SREBF1 Antibodies)/Cyclin D1 (show CCND1 Antibodies) signaling pathway.

2. These findings suggest that mTOR is involved in the control of the expression of multiple genes in cattle, which may be triggered by the luteinizing hormone surge.

3. 14-3-3gamma (show YWHAG Antibodies) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.

4. Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (show JAK2 Antibodies)-STAT5 (show STAT5A Antibodies) and mTOR signaling pathways.

5. Insulin (show INS Antibodies)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.

6. IGF-I (show IGF1 Antibodies) down-regulated functional IGF-I receptor (show IGF1R Antibodies) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (show IGF1R Antibodies) level in nonstimulated cells.

7. stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (show INS Antibodies), and prolactin (show PRL Antibodies) were associated with increased phosphorylation of the mTOR substrates

8. data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

9. prostaglandin F2alpha phosphorylates TSC2 (show TSC2 Antibodies) and activates mTOR and ribosomal protein S6 (show RPS6 Antibodies) kinase (show RPS6KB1 Antibodies) signaling in an AKT (show AKT1 Antibodies)-independent manner

10. mTOR links IGF-I (show IGF1 Antibodies) and EGF (show EGF Antibodies) signaling in inhibiting the autophagy pathways.