Browse our anti-MTOR (FRAP1) Antibodies

Horse (Equine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

Human Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

1. High mTOR expression is associated with gastric cancer.

2. The authors demonstrate that, particularly when autophagy is upregulated, varicella-zoster virus inhibits mTOR-mediated late-stage autophagic flux, likely at the point where autophagosomes and lysosomes fuse or where vesicle contents are degraded. Importantly, inhibition of autophagy yields higher varicella-zoster virus titers.

3. Identification of a functional mTOR targeted multigene signature robustly discriminates between normal prostate tissues, primary tumors, and hormone refractory metastatic samples but is also predictive of cancer recurrence

4. 2-ME reduced the production of CTGF (show CTGF Antibodies) and collagen I in SSc (show CYP11A1 Antibodies) fibroblasts induced by hypoxia through PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/mTOR/HIF-1alpha (show HIF1A Antibodies) signalling and inhibited the proliferation of fibroblasts. These findings suggested that 2-ME could be employed as a promising antifibrotic therapy for SSc (show CYP11A1 Antibodies)

5. Studies indicate that understanding mTOR network circuitry will provide insight into its deregulation in diabetes, cancer, and cardiovascular disease, but modeling in silico to elucidate how insulin (show INS Antibodies) activates mTORC2 (show CRTC2 Antibodies) remains poorly defined.

6. miR33a5p inhibited the proliferation of lung adenocarcinoma cells, enhanced the antitumor effect of celastrol, and improved sensitivity to celastrol by targeting mTOR in lung adenocarcinoma in vitro and in vivo

7. miR (show MLXIP Antibodies)-181 may be a novel and important regulator of cisplatin-resistant non-small cell lung cancer by serving a role in the regulation of apoptosis, as an established rate-limiting miRNA target.

8. Evaluation of the potential mechanism demonstrated that TRIM28 (show TRIM28 Antibodies) promoted cervical cancer cell growth by activating the mammalian target of rapamycin (mTOR) signaling pathway. In support of this finding, TRIM28 (show TRIM28 Antibodies)-induced cell proliferation was abolished by treatment with everolimus, a specific mTOR inhibitor

9. MiR (show MLXIP Antibodies)-101 and mTOR expressions significantly declined in endometrial cancer (EC) tissue.

10. while mTOR inhibitors restore endocrine sensitivity, CDK4/6 (show CDK4 Antibodies) inhibitors may favor the emergence of estrogen receptor 1 (ESR1 (show ESR1 Antibodies)) mutations resulting in ligand-independent activity of the receptor

Mouse (Murine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

1. The control of cMaf (show MAF Antibodies) expression at the translational level by mTOR regulated the expression of inflammatory genes in response to lipopolysaccharide challenge.

2. The function of mTOR in epidermal morphogenesis is split between mTORC1 and mTORC2 (show CRTC2 Antibodies). Whereas mTORC1 mainly controls keratinocyte proliferation within the basal layer, early epidermal stratification and differentiation, mTORC2 (show CRTC2 Antibodies) primarily controls cell division orientation and late stage barrier formation of the interfollicular epidermis.

3. Loss of mTOR in vasoactive intestinal peptide (show Vip Antibodies) neurons displayed erratic circadian behavior and weakened synchronization among cells in the suprachiasmatic nucleus, the master circadian pacemaker.

4. T1R1 (show TAS1R1 Antibodies)/T1R3 (show TAS1R3 Antibodies) modulates the mTOR pathway to regulate milk protein synthesis in the mouse mammary gland in vivo.

5. the protein expression levels of mTOR were significantly reduced in spinal cord injury (SCI) neurons, whereas transfection with a miR99b5p inhibitor suppressed the SCIinduced reduction of mTOR.

6. Adoptive transfer with targeting-mTOR strategy markedly improves neuronal recovery after ONI, supporting the therapeutic potentials of Tregs in acute and chronic neurological disorder

7. Activation of the mTOR pathway was partially repressed by T1R1 (show TAS1R1 Antibodies) siRNA or SLC7A5 (show SLC7A5 Antibodies)/SLC3A2 (show SLC3A2 Antibodies) inhibitor (BCH (show CHN2 Antibodies), 10 mM), and the combination of these two treatments further repressed the activity of mTOR pathway.

8. Ggpps (show GGPS1 Antibodies) deletion enhanced Rheb (show RHEB Antibodies) farnesylation, which subsequently activated mTORC1 and facilitated spermatogonial differentiation

9. mTOR is crucial for T-cell accumulation in the GI tract and for establishing local adaptive immunity against pathogens.

10. Data show that mammalian/mechanistic target of rapamycin (mTOR) perturbation alters the suprachiasmatic nucleus (SCN (show SRI Antibodies)) clock oscillations.

Zebrafish Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

1. This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (show ESCO2 Antibodies) cells and supports that normal gene expression and translation requires ESCO2 (show ESCO2 Antibodies) function.

2. By inhibiting mTOR signaling via Fbxw7 (show FBXW7 Antibodies), the amount of myelination during development is reduced.

3. Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish

4. In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (show TP53 Antibodies).

5. TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.

6. in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine

Pig (Porcine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

1. The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg (show PPARG Antibodies). In summary, PPARg (show PPARG Antibodies) plays an important role in the regulation of IGF-1 (show IGF1 Antibodies) secretion and gene expression in response to dietary protein.

2. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt (show AKT1 Antibodies)-mTOR-FOXO1 (show FOXO1 Antibodies) signaling and suppressing the activation of TLR4 (show TLR4 Antibodies) and/or NOD2 (show NOD2 Antibodies) signaling pathways.

3. Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).

4. AMPK (show PRKAA1 Antibodies)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.

5. Uroguanylin (show GUCA2B Antibodies) modulates (Na++K+)ATPase (show ATP1A1 Antibodies) in a proximal tubule cells via cGMP/protein kinase (show CDK7 Antibodies) G, cAMP/protein kinase A, and mTOR pathways.

6. mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (show CCND1 Antibodies), and CCNE1 (show CCNE1 Antibodies).

7. L-Glutamine (show GFPT2 Antibodies) enhances enterocyte growth via activation of the mTOR.

8. Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr (show PTCHD3 Antibodies) cells through activation of the MTOR-RPS6K-RPS6 (show RPS6 Antibodies)-EIF4EBP1 (show EIF4EBP1 Antibodies) signal transduction pathway.

9. Data indicate that the expression of MAP1LC3A (show MAP1LC3A Antibodies), B and autophagy-associated genes (ATG5 (show ATG5 Antibodies), mTOR, Beclin-1 (show BECN1 Antibodies)) was increased in normal pigs, while decreased in miniature pigs.

10. Biochemical, cellular, and molecular data suggest that L-arginine (show GATM Antibodies) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.

Cow (Bovine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

1. AnxA2 (show ANXA2 Antibodies) functions as a critical regulator for amino acid or hormone-induced milk synthesis and mammary gland epithelial cell proliferation via the PI3K-mTOR-SREBP-1c (show SREBF1 Antibodies)/Cyclin D1 (show CCND1 Antibodies) signaling pathway.

2. These findings suggest that mTOR is involved in the control of the expression of multiple genes in cattle, which may be triggered by the luteinizing hormone surge.

3. 14-3-3gamma (show YWHAG Antibodies) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.

4. Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (show JAK2 Antibodies)-STAT5 (show STAT5A Antibodies) and mTOR signaling pathways.

5. Insulin (show INS Antibodies)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.

6. IGF-I (show IGF1 Antibodies) down-regulated functional IGF-I receptor (show IGF1R Antibodies) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (show IGF1R Antibodies) level in nonstimulated cells.

7. stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (show INS Antibodies), and prolactin (show PRL Antibodies) were associated with increased phosphorylation of the mTOR substrates

8. data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

9. prostaglandin F2alpha phosphorylates TSC2 (show TSC2 Antibodies) and activates mTOR and ribosomal protein S6 (show RPS6 Antibodies) kinase (show RPS6KB1 Antibodies) signaling in an AKT (show AKT1 Antibodies)-independent manner

10. mTOR links IGF-I (show IGF1 Antibodies) and EGF (show EGF Antibodies) signaling in inhibiting the autophagy pathways.