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miR (show MYLIP Proteins)-375 directly targeted PDK1 (show PDK1 Proteins) in porcine pancreatic stem cells suppressing cell proliferation and differentiation into islet-like cells.
the combination of BX-912 and ABT-263, a BH3 mimetic, resulted in the enhancement of the induction of apoptosis. In conclusion, our results suggest that PDPK1 is a potential novel therapeutic target in Mantle cell lymphoma (MCL (show FH Proteins)) and indicate that clinical development of PDPK1-targeted therapy for MCL (show FH Proteins) is desirable.
Our experimental results suggested that PDK1 (show PDK1 Proteins) may promote chondrocyte apoptosis in osteoarthritis via p38 MAPK (show MAPK14 Proteins) signaling pathway
our results offer significant insight into how PIK3CA (show PIK3CA Proteins) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K (show PIK3CA Proteins)/PDK1 (show PDK1 Proteins) and TGFb (show TGFB1 Proteins) signaling in advanced HNSCC patients with PIK3CA (show PIK3CA Proteins) amplification
Ribociclib, in combination with GSK2334470 or the PI3Kalpha (show PIK3CA Proteins) inhibitor alpelisib, decreased xenograft tumor growth more potently than each drug alone. Taken together, our results highlight a role for the PI3K (show PIK3CA Proteins)-PDK1 (show PDK1 Proteins) signaling pathway in mediating acquired resistance to CDK4/6 (show CDK4 Proteins) inhibitors.
Decreased PDK1 (show PDK1 Proteins) protein expression in A2058 cells.
Together these results indicate a strong potential regulatory role for PDK1 (show PDK1 Proteins) in OC stimulatory pathways (Akt (show AKT1 Proteins), ERK (show EPHB2 Proteins)) and autophagy induction (via mTORC1), which may contribute to the OC phenotype in Paget's disease of bone.
It targeted the 3-phosphoinositide-dependent protein kinase 1 gene that appeared to be a potent regulator of AKT (show AKT1 Proteins).
High (show PDK1 Proteins)ly expressed PDK1 could promote cell invasion and secretion of IL-1beta and IL-6 in human rheumatoid arthritis s (show PDK1 Proteins)ynovial (show PDK1 Proteins)MH7A c (show RPS6KA3 Proteins)ells. Inhib (show RPS6KA3 Proteins)ition of RSK2 reduced the PDK (show ASF1A Proteins)1-induced cell invasion and cytokines secretion (show PDK1 Proteins) in M (show RPS6KA3 Proteins)H7A cells. In response to TNF-alpha, PDK1 could phosphorylate RSK2 and activated RSK2, then promoting the activation of NF-kappaB.
In cancer cells resistant to PI3Kalpha inhibition, PDK1 blockade restores sensitivity to these therapies. SGK1, which is activated by PDK1, contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2.
Results suggest that Ser (show SIGLEC1 Proteins)-64 is an important phosphorylation site that is part of a positive feedback loop for human PDK1 (show PDK1 Proteins)-PKCtheta (show PRKCQ Proteins);-mediated T cell activation.
our results offer significant insight into how PIK3CA (show PIK3CA Proteins) overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K/PDK1 and TGFb (show TGFB1 Proteins) signaling in advanced HNSCC patients with PIK3CA (show PIK3CA Proteins) amplification
PDK1 signaling regulates the basal-to-suprabasal switch in developing epidermis by acting as both an activator and organizer of asymmetric cell division and the Notch (show NOTCH1 Proteins)-dependent differentiation program.
Data indicate that mammary-specific ablation of 3-phosphoinositide dependent protein kinase 1 (PDK1) could delay tumor initiation, progression and metastasis in a spontaneous mouse tumor model.
PDK1 was highly expressed in synovia of collagen-induced-arthritis mice compared to control. The expressions of PDK1, p-PDK1, RSK2 (show RPS6KA3 Proteins) and p-RSK2 (show RPS6KA3 Proteins) were all up-regulated in CIA (show NCOA5 Proteins) compared with normal. This indicated that PDK1/RSK2 (show RPS6KA3 Proteins) may participate in inflammatory progress of RA.
PDK1 is required for Ca(2 (show CA2 Proteins)+)-dependent platelet activation on stimulation of collagen receptor (show ITGA2 Proteins) glycoprotein VI, arterial thrombotic occlusion, and ischemic stroke in vivo.
In conclusion, we have identified that ARL15 acts as an insulin (show INS Proteins)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (show IRS1 Proteins)/PDPK1/AKT (show AKT1 Proteins) insulin (show INS Proteins) pathway by interacting with its GAP ASAP2 (show ASAP2 Proteins) and activating PDPK1. This research may provide new insights into GTPase (show RACGAP1 Proteins)-mediated insulin (show INS Proteins) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS Proteins) sensitizati
Only when suboptimal doses of Akt (show AKT1 Proteins)-Pdpk1 interaction inhibitor NSC156529 were used an additive effect with Notch (show NOTCH1 Proteins) inhibition was seen. We conclude that the Akt (show AKT1 Proteins) pathway inhibitor NSC156529 is potentially useful as single treatment for liver tumors with hyperactivated Akt (show AKT1 Proteins) signaling.
Xanthium strumarium methanolic extract exerts anti-inflammatory activity in vitro and in vivo by inhibiting PDK1 kinase activity and blocking signaling to its downstream transcription factor, NF-kappaB (show NFKB1 Proteins).
PDPK1 is required for exercise-induced cardiac hypertrophy but does not contribute to exercise-induced increases in mitochondrial function.
The PDK1 knock-in mice displayed a reduced brain size due to a reduction in neuronal cell size rather than cell number.
at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (show PIK3C3 Proteins) (PI3K)
Piriformospora indica-stimulated growth response is mediated by a pathway consisting of the PLD-PDK1-OXI1 cascade.
PDK1 (show PDK1 Proteins) undergoes autophosphorylation at several sites; mutation of Ser (show SIGLEC1 Proteins)-276 to Ala resulted in enzyme with no detectable autophosphorylation; other sites important for autophosphorylation &/or activity were Asp (show ASIP Proteins)-167, Thr (show TRH Proteins)-176, & Thr (show TRH Proteins)-211
PDK1 (show PDK1 Proteins) is a potent enhancer of PID (show MTA2 Proteins) activity.
specific lipid signaling pathways converge on PTI1-2 via the PDK1-OXI1 axis
Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.
3-phosphoinositide-dependent protein kinase 1
, 3-phosphoinositide dependent protein kinase-1
, pkB kinase
, protein kinase B kinase
, PkB kinase like gene 1
, Pkb kinase