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Study shows that in myelin maturation ApoD ultimately controls the removal of the sialic-rich hydrophilic glycocalyx, by maintaining functional integrity of lysosomes. A detailed analysis of the mechanism reveals that the proper localization of Neu1 (show NEU1 Proteins) and plasma membrane Neu3 (show Neu3 Proteins), as well as of the membrane-bound Fyn (show FYN Proteins) kinase, depend on ApoD.
These results provide additional mechanistic information on the apoD-mediated neuroprotection in neurodegenerative conditions.
This study demonstrated that Apo D is mainly located in glial cells while Apo J (show CLU Proteins) expression preferentially occurs in neurons in brain with patient with Alzheimer's Disease.
ApoD expression is likely not a predictor of recurrence in tamoxifen-treated patients. IMPACT: This study eliminates the previously suggested marker ApoD as a predictor of recurrence among tamoxifen-treated women
The high rate of APOD expression in HGPIN and cancer, as well as the absence of its expression in the vast majority of morphologically normal glands allows the use of this protein as an additional marker in the differential diagnosis of prostatic neoplasms.
Our results provide a viable solution to the production of recombinant ApoD protein in lieu of previous obstacles in generating soluble and functional ApoD protein
apoD protein levels are variable across different brain regions.
The data suggest that the presence of Apo D in the nucleus, which some authors related with a specific transport, is a consequence of structural and functional alterations during oxidative stress
hepatic steatosis observed in apoD Tg mice is a consequence of increased PPARgamma (show PPARG Proteins) transcriptional activity by AA leading to increased fatty acid uptake by the liver
The SNP rs7659 within the APOD gene might be related to risk and severity of ischemic stroke in patients.
Study shows that in myelin maturation ApoD ultimately controls the removal of the sialic-rich hydrophilic glycocalyx, by maintaining functional integrity of lysosomes. A detailed analysis of the mechanism reveals that the proper localization of Neu1 (show NEURL Proteins) and plasma membrane Neu3 (show Neu3 Proteins), as well as of the membrane-bound Fyn (show FYN Proteins) kinase, depend on ApoD.
apoD may be part of an intrinsic cardioprotective system, possibly as a consequence of its antioxidation activity.
Changes in hypothalamus of ApoD(-/-) mice may indicate potential role of ApoD in regulation of endocrine functions of somatostatin (show SST Proteins) in a receptor-dependent manner.
Abeta25-35 induces neuroprotective ApoD expression in hippocampal cells in response to stress-induced growth arrest.
The findings underscore the importance of ApoD in the regulation of plasma insulin (show INS Proteins) levels and triglyceride metabolism, suggesting that ApoD plays an important role in the pathogenesis of dyslipidemia.
The data of this study supported that ApoD contributes to the endurance of astrocytes and decreases their reactivity level in vitro and in vivo
Scanning cytometry revealed PACAP (show ADCYAP1 Proteins)/ApoD induced low density lipoprotein receptors (LDLR (show LDLR Proteins)) and ApoE receptor 2 (apoER2 (show LRP8 Proteins)) in NF200 (show NEFH Proteins)-positive cells.
mRNA and protein expression profiles reveal that ApoD is functionally connected in an age-dependent manner to specific molecular programs triggered by injury.
Apolipoprotein D plays a significant role in lipid metabolism.
This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism.
, Apolipoprotein D
, apolipoprotein D-like