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Association of higher ApoD levels in fat depots with improved metabolic health in severely obese women.
Study shows that in myelin maturation ApoD ultimately controls the removal of the sialic-rich hydrophilic glycocalyx, by maintaining functional integrity of lysosomes. A detailed analysis of the mechanism reveals that the proper localization of Neu1 and plasma membrane Neu3, as well as of the membrane-bound Fyn kinase, depend on ApoD.
These results provide additional mechanistic information on the apoD-mediated neuroprotection in neurodegenerative conditions.
This study demonstrated that Apo D is mainly located in glial cells while Apo J expression preferentially occurs in neurons in brain with patient with Alzheimer's Disease.
ApoD expression is likely not a predictor of recurrence in tamoxifen-treated patients. IMPACT: This study eliminates the previously suggested marker ApoD as a predictor of recurrence among tamoxifen-treated women
The high rate of APOD expression in HGPIN and cancer, as well as the absence of its expression in the vast majority of morphologically normal glands allows the use of this protein as an additional marker in the differential diagnosis of prostatic neoplasms.
Our results provide a viable solution to the production of recombinant ApoD protein in lieu of previous obstacles in generating soluble and functional ApoD protein
apoD protein levels are variable across different brain regions.
The data suggest that the presence of Apo D in the nucleus, which some authors related with a specific transport, is a consequence of structural and functional alterations during oxidative stress
hepatic steatosis observed in apoD Tg mice is a consequence of increased PPARgamma transcriptional activity by AA leading to increased fatty acid uptake by the liver
The SNP rs7659 within the APOD gene might be related to risk and severity of ischemic stroke in patients.
apoD mediates binding of high density lipoprotein to low density lipoprotein and to growing T24 carcinomas, thereby highlighting the importance of apoD in lipid metabolism.
The internalization of apoD is mediated by basigin.
ApoE is located in the nucleus and on the ApoD promoter in human hepatic and glioblastoma cells lines.
Rs7659, 3' UTR polymorphism of the APOD gene was associated with early onset Alzheimer disease in APOEepsilon4 (-) subgroup. Our results suggest that the variation of the APOD gene modifies the risk for Alzheimer disease.
ApoD mRNA expression is seen in whole endometrium, stromal and epithelial cells in the secretory phase, as well as after hormonal stimulation in vitro.
We propose that strong brainstem expression of Apo D throughout adult life contributes to resistance against neurodegenerative disease and age-related degeneration, possibly by preventing oxidative stress and ensuing lipid peroxidation.
ApoD is marker of initial stages of colorectal cancer progression.
Data suggest that ApoD binds various lyophilic ligands: retinoic acid, retinol, fatty acids, sphingomyelin, and anandamide. ApoD successfully delivers retinoic acid to immature neuronal cell line resulting in neurogenesis (i.e., neurite formation).
Molecular dynamics analysis of apolipoprotein-D-lipid hydroperoxide interactions show the mechanism for selective oxidation of Met-93
It regulates amyloid plaque pathology in a mouse model of Alzheimer's disease
apoD may be part of an intrinsic cardioprotective system, possibly as a consequence of its antioxidation activity.
Changes in hypothalamus of ApoD(-/-) mice may indicate potential role of ApoD in regulation of endocrine functions of somatostatin in a receptor-dependent manner.
Abeta25-35 induces neuroprotective ApoD expression in hippocampal cells in response to stress-induced growth arrest.
The findings underscore the importance of ApoD in the regulation of plasma insulin levels and triglyceride metabolism, suggesting that ApoD plays an important role in the pathogenesis of dyslipidemia.
The data of this study supported that ApoD contributes to the endurance of astrocytes and decreases their reactivity level in vitro and in vivo
Scanning cytometry revealed PACAP/ApoD induced low density lipoprotein receptors (LDLR) and ApoE receptor 2 (apoER2) in NF200-positive cells.
mRNA and protein expression profiles reveal that ApoD is functionally connected in an age-dependent manner to specific molecular programs triggered by injury.
Apolipoprotein D plays a significant role in lipid metabolism.
This study concluded that glutamatergic pathways seem to be particularly affected in ApoD(-/-) mice.
Expression pattern of the lipocalin apolipoprotein D during mouse embryogenesis.
Apolipoprotein D-immunolabeled cells are observed in select grey matter nuclei, including the globus pallidus, thalamus, and substantia nigra, and in white matter tracts within the internal capsule and cerebellum of Neimann-Pick type C mouse brain.
apolipoprotein D and the lipogenic protein Spot 14 are LXR alpha and LXRB responsive genes both in vitro and in vivo
ApoD messenger RNA expression was localised to the spiral ligament and spiral limbus, particularly in the suprastrial and supralimbral regions.
These observations, together with its transcriptional up-regulation in the brain upon oxidative insult, identify ApoD as an acute response protein with a protective and therefore beneficial function mediated by the control of peroxidated lipids.
Taken together, our results describe receptor and region specific changes in SST and SSTR subtypes expression in ApoD(-/-) mice brain, which may be linked to specific neurological disorders.
This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism.
, Apolipoprotein D
, apolipoprotein D-like