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review elucidates the role of tumor stroma interactions, the roles of PDGF receptor signaling in cancer-associated fibroblasts via alteration of stromal matrix composition and the mitogenic effects of cancer-derived PDGFs.
Data indicate the association between SNP rs17633132:C/T in PDGFRL with Behcet disease and suggest that the PDGFRL gene may be involved in Behcet disease by modulating its transcription.
Results indicate that PDGFRL functions as a tumor suppressor, inhibiting the growth of colorectal cancer cells.
These findings suggest that PDGFRL plays the different roles, depending upon cell types. Particularly, in chondrocytes, PDGFRL may play a new and important role which is distinct from the function previously reported.
This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor.
platelet-derived growth factor receptor-like protein
, platelet-derived growth factor receptor-like
, platelet-derived growth factor receptor-like protein-like
, PDGF receptor beta-like tumor suppressor
, PDGFR-like protein
, platelet-derived growth factor-beta-like tumor suppressor