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CER/BOK-induced regulation of mitochondrial fission and its functional consequence for heightened trophoblast cell autophagy in preeclampsia.
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BOK downregulation may be associated with tumorigenesis of testicular cancer (TC); BOK had the potency to suppress TC cell proliferation and invasion, and BOK also contributes to Cisplatin resistance.
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These data indicate BOK as a prognostic marker in colorectal cancer.
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Loss of BOK is associated with non-small-cell lung carcinoma.
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These results not only establish Bok as a Bak- and Bax-independent apoptosis inducer, but also suggest a potential impact of Bok expression in ovarian cancer therapy.
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Data suggest that endoplasmic reticulum (ER) stress-induced apoptosis in hepatoma cells is regulated by highly labile and ER-associated BCL-2 family member BOK, which is controlled at level of protein stability by ER-associated degradation components; DNAJB12 is required in hepatoma cells to maintain BOK at low levels and suppress ER stress. (DNAJB12 = DnaJ (Hsp40) homolog, subfamily B, member 12)
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Data suggest that hypoxia-induced expression of BOK in placental cells is regulated via promoter region, hypoxia-response element, and binding of hypoxia-inducible factors (HIF1A, HIF2A/EPAS1, HIF1B/ARNT) but is not affected by its antisense transcript.
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First evidence for a key role of the BOK-MCL1 system in regulating autophagy in the human placenta, whereby an adverse environment as seen in preeclampsia tilts the BOK-MCL1 balance toward the build-up of isoforms that triggers placental autophagy.
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Bok may govern IP3R cleavage and activity during apoptosis.
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The results suggest important roles for Bok and Bcl-X(L) in human ovarian development, follicle maturation and apoptosis.
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Data conclude that Mtd-L functions to regulate trophoblast cell proliferation during early placentation and that the elevated levels of Mtd found in PE may contribute to increased trophoblast proliferation.
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BOK and NOXA are essential mediators of p53-dependent apoptosis
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A novel Mtd/BOK splice isoform is responsible for trophoblast cell death in pre-eclampsia.
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Studies showed that hBok was distributed in both the cytosol and intracellular membranes of healthy cells.
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a link between the apoptotic activity and nuclear localization of a pro-apoptotic Bok
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Bok represents a cell cycle-regulated pro-apoptotic member of the Bcl-2 family
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BOKAS is a natural antisense transcript that regulates the pro-apoptotic activity of human Bok