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anti-Human BOK Antibodies:
anti-Rat (Rattus) BOK Antibodies:
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Human Polyclonal BOK Primary Antibody for IHC (p), WB - ABIN388103
Hsu, Kaipia, McGee, Lomeli, Hsueh: Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. in Proceedings of the National Academy of Sciences of the United States of America 1997
Show all 4 Pubmed References
Loss of BOK is associated with non-small-cell lung carcinoma.
These results not only establish Bok as a Bak (show BAK1 Antibodies)- and Bax (show BAX Antibodies)-independent apoptosis inducer, but also suggest a potential impact of Bok expression in ovarian cancer therapy.
Data suggest that endoplasmic reticulum (ER) stress-induced apoptosis in hepatoma cells is regulated by highly labile and ER-associated BCL-2 (show BCL2 Antibodies) family member BOK, which is controlled at level of protein stability by ER-associated degradation components; DNAJB12 (show DNAJB12 Antibodies) is required in hepatoma cells to maintain BOK at low levels and suppress ER stress. (DNAJB12 (show DNAJB12 Antibodies) = DnaJ (Hsp40 (show DNAJB1 Antibodies)) homolog (show DNAJB4 Antibodies), subfamily B (show CYP Antibodies), member 12)
Data suggest that hypoxia-induced expression of BOK in placental cells is regulated via promoter region, hypoxia-response element, and binding of hypoxia-inducible factors (HIF1A (show HIF1A Antibodies), HIF2A/EPAS1 (show EPAS1 Antibodies), HIF1B/ARNT (show ARNT Antibodies)) but is not affected by its antisense transcript.
First evidence for a key role of the BOK-MCL1 (show MCL1 Antibodies) system in regulating autophagy in the human placenta, whereby an adverse environment as seen in preeclampsia tilts the BOK-MCL1 (show MCL1 Antibodies) balance toward the build-up of isoforms that triggers placental autophagy.
Bok may govern IP3R (show ITPR1 Antibodies) cleavage and activity during apoptosis.
The results suggest important roles for Bok and Bcl-X(L (show BCL2L1 Antibodies)) in human ovarian development, follicle maturation and apoptosis.
Data conclude that Mtd (show MT1E Antibodies)-L functions to regulate trophoblast cell proliferation during early placentation and that the elevated levels of Mtd (show MT1E Antibodies) found in PE may contribute to increased trophoblast proliferation.
BOK and NOXA (show PMAIP1 Antibodies) are essential mediators of p53 (show TP53 Antibodies)-dependent apoptosis
A novel Mtd/BOK splice isoform is responsible for trophoblast cell death in pre-eclampsia.
we show that BOK(C) can permeabilize liposomes, and cooperate with cBID, but its role in directly mediating mitochondrial permeabilization is unclear and may underlie a yet to be determined negative regulation.
Bok controls neuronal Ca(2 (show CA2 Antibodies)+) homeostasis and bioenergetics in seizure-induced neuronal injury.
Study reports that BCL-2 (show BCL2 Antibodies) ovarian killer (BOK) is a bona fide yet unconventional effector of mitochondrial outer membrane permeabilization that can trigger apoptosis in the absence of both BAX (show BAX Antibodies) and BAK (show BAK1 Antibodies).
findings support a selective and distinguishing role for BOK in regulating the apoptotic response to ER stress, revealing--to our knowledge--the first bona fide apoptotic defect linked to Bok deletion
BOK-deficient mice have no readily discernible abnormalities, and its function therefore remains unresolved.
two proapoptotic Bcl-2 family members Bok and Noxa/Pmaip are directly transcriptionally induced by activated MAL and upon activation of the actin-MAL-SRF pathway
Bok protein have a role that largely overlaps with that of other members of the Bcl-2 (show BCL2 Antibodies) family, or may have a function restricted to specific stress stimuli and/or tissues.
Bok represents a cell cycle-regulated pro-apoptotic member of the Bcl-2 (show BCL2 Antibodies) family
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding different proteins have been identified.
bcl-2-related ovarian killer protein
, BCL2-related ovarian killer
, Bcl-2-related ovarian killer
, bcl-2-related ovarian killer protein homolog A
, bcl-2-related ovarian killer protein homolog B
, bcl-2-like protein 9
, ATP synthase lipid-binding protein, mitochondrial
, ATP synthase proteolipid P3
, ATP synthase subunit 9
, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)
, ATP synthase, mitochondrial, C subunit-3
, ATPase protein 9
, ATPase subunit C
, apoptosis activator Mtd
, protein matador