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SOX7 transcription factor mediates PDGF (show PDGFA Proteins)-BB-induced IL-33 (show IL33 Proteins) expression.
Mechanistically, SOX7 was confirmed to be the downstream target of miR (show MLXIP Proteins)-616 in NSCLC cells. Forced expression of SOX7 prevented the promoting effects of miR (show MLXIP Proteins)-616 overexpression on the proliferation and metastasis of NSCLC cells, while knockdown of SOX7 reversed the inhibitory effects of miR (show MLXIP Proteins)-616 knockdown on the proliferation and metastasis of NSCLC cells.
miR (show MLXIP Proteins)-9 was up-regulated and SOX7 was down-regulated in human non-small-cell lung cancer tissues and cell lines.
The results indicate that SOX7 may inhibit the progression of liver carcinoma and that SOX7 downregulation may accurately predict poor prognosis in liver carcinoma patients.
Consistent with bioinformatics predictions, SOX7 was correlated positively with AXIN2 (show AXIN2 Proteins) and negatively with beta-catenin (show CTNNB1 Proteins), suggesting that SOX7 and AXIN2 (show AXIN2 Proteins) might play important roles as co-regulators through the Wnt (show WNT2 Proteins)-beta-catenin (show CTNNB1 Proteins) pathway in the breast tissue to affect the carcinogenesis process.
SOX7 inhibits oncogenic beta-catenin (show CTNNB1 Proteins)-mediated transcription by disrupting the beta-catenin (show CTNNB1 Proteins)/BCL9 (show BCL9 Proteins) interaction.
Overexpression of miR (show MLXIP Proteins)-935 inhibited SOX7 expression.
The results suggest that miR (show MLXIP Proteins)-664 functions as an oncogene (show RAB1A Proteins) miRNA and has an important role in promoting human osteosarcoma cell invasion and migration by suppressing SOX7 expression.
miR (show MLXIP Proteins)-595 played a critical role in carcinogenesis by suppression of SOX7.
Aberrant methylation of the promoter regions of the SOX7 gene in patients with acute myeloid leukemias.
SOX7 is dispensable for myogenesis but is necessary to promote satellite cell development and survival.
By E10.5, both Sox7 complete knockout and FLK1 (show KDR Proteins)-specific deletion of Sox7 lead to widespread vascular defects. In contrast, while SOX7 is expressed in the earliest specified blood progenitors, the VAV (show VAV1 Proteins)-specific deletion of Sox7 does not affect the hematopoietic system. Together, our data reveal the unique role of SOX7 in vasculogenesis and angiogenesis during embryonic development.
Data provide evidence that the uncontrolled expression of the transcription factor SOX7 in adult haematopoietic cells has dramatic consequences on blood homeostasis with alterations of the haematopoietic system, inducing the proliferation of blood progenitors in the bone marrow while blocking B lymphopoiesis.
SOX7 inhibits the expression of RUNX1 (show RUNX1 Proteins) target genes in hemogenic endothelium, while having no effect on RUNX1 (show RUNX1 Proteins) expression itself. SOX7 directly interacts with RUNX1 (show RUNX1 Proteins) and inhibits its transcriptional activity.
Dynamically and epigenetically coordinated GATA2 (show GATA2 Proteins)/ETS1SOX7 transcription factor expression is indispensable for endothelial cell differentiation.
combined deletion of Sox7, Sox17 (show SOX17 Proteins), and Sox18 (show SOX18 Proteins) at the onset of retinal angiogenesis leads to a dense capillary plexus with a nearly complete loss of radial arteries and veins, whereas the presence of a single Sox17 (show SOX17 Proteins) allele largely restores arterial identity
These data indicate that Sox7 is dispensable for both differentiation and maturation of primitive endoderm in an mouse embryonic stem cell model system.
ETV2 (show ETV2 Proteins) directly regulates Sox7, and ETV2 (show ETV2 Proteins) governs endothelial development by regulating transcriptional networks which include Sox7.
Notch (show NOTCH1 Proteins) and SoxF factors combinatorially regulate Dll4 (show DLL4 Proteins) expression in arteries downstream of VEGF (show VEGFA Proteins).
Haploinsufficiency of Sox7 or Gata4 (show GATA4 Proteins) is sufficient to produce anterior congenital diaphragmatic hernia in mice.
Sox7 levels are crucial in arterial specification in conjunction with hey2 (show HEY2 Proteins) and efnb2 (show EFNB2 Proteins) function, with mutants in all three genes displaying shunt formation and an arterial block.
Sox7/18 factors and Notch (show NOTCH1 Proteins) regulate nr2f2 (show NR2F2 Proteins) gene expression during venous differentiation in zebrafish.
Sox7 and Sox18 (show SOX18 Proteins)-mediated transcriptional regulation of Robo4 (show ROBO4 Proteins) is important in the developing embryonic vasculature
Sox7 and sox18 (show SOX18 Proteins) are specifically expressed in the developing vasculature, and simultaneous loss of their function results in a severe loss of the arterial identity of the presumptive aorta.
Sox7 and sox18 (show SOX18 Proteins) play redundant but collectively essential roles in the establishment of proper arteriovenous identity in zebrafish.
Sox7 and Sox18 (show SOX18 Proteins) control arterial-venous identity by regulating Gridlock (show HEY2 Proteins) expression.
SOX7 mRNA is localized to the vegetal region of the blastula-stage embryo
SOX7 and SOX18b are essential regulators of cardiogenesis in Xenopus.
Vegetal pole localized Sox7 positively regulates Nodal (Xnr4, Xnr5, and Xnr6) expression, as well as the expression of genes involved in mesodermal (Xmenf, Slug, and Snail) and endodermal (Endodermin and Sox17beta) differentiation.
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway.
transcription factor SOX-7
, SRY-box containing gene 7
, SRY (sex determining region Y)-box 7
, SRY (sex determining region Y)-box 7, xSox7 protein
, transcription factor Sox-7