No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Rat (Rattus) TFAP4 Antibodies:
anti-Human TFAP4 Antibodies:
anti-Mouse (Murine) TFAP4 Antibodies:
Go to our pre-filtered search.
Cow (Bovine) Polyclonal TFAP4 Primary Antibody for WB - ABIN2780083
Tsujimoto, Ono, Sato, Nishida, Oguma, Tadakuma: Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis. in The Journal of biological chemistry 2005
Human Polyclonal TFAP4 Primary Antibody for IP - ABIN4358615
Huang, Kesselman, Kizub, Guerrero-Preston, Ratovitski: Phospho-?Np63?/microRNA feedback regulation in squamous carcinoma cells upon cisplatin exposure. in Cell cycle (Georgetown, Tex.) 2013
Human Polyclonal TFAP4 Primary Antibody for IHC, IHC (p) - ABIN4358617
Jackstadt, Röh, Neumann, Jung, Hoffmann, Horst, Berens, Bornkamm, Kirchner, Menssen, Hermeking: AP4 is a mediator of epithelial-mesenchymal transition and metastasis in colorectal cancer. in The Journal of experimental medicine 2013
These results provide new insight into the mechanisms underlying hyperactivation of the Wnt/beta-catenin pathway in hepatocellular carcinoma, as well the oncogenic ability of TFAP4 to enhance the tumor-forming ability of hepatocellular carcinoma cells via its binding to the promoters of DVL1 (dishevelled segment polarity protein 1) and LEF1 (lymphoid enhancer binding factor 1).
TRIB2 suppresses cellular senescence through interaction with AP4 to down-regulate p21 expression.
TFAP4 is a key regulator of MYCN-amplified neuroblastom
Findings identify LAPTM4B as a direct AP4 target gene and the interaction of AP4 and LAPTM4B plays an important role in breast cancer progression.Implications: This study demonstrates that AP4 promotes cell growth, migration, invasion, and cisplatin resistance through upregulation of LAPTM4B expression.
AP4-associated signatures are conserved between murine adenomas and human colorectal cancer samples. Results establish Ap4 as rate-limiting mediator of adenoma initiation, as well as regulator of intestinal and colonic stem cell and Paneth cell homeostasis.
these findings support a plausible mechanism by which the AP4/L-plastin axis is regulated by the PI3K/AKT pathway in human prostate cancer (PCa)and may represent a novel therapeutic target in PCa treatment.
Results show that AP4 is overexpressed in primary carcinoma compared with the non-cancerous mucosa and is up-regulated in EMT in colorectal cancer (CRC) cells. Its overexpression is correlated with liver metastasis in CRC and poor outcome. Also, The study show that USP22 binds to the promoter region of AP4 to activate its transcription.
Data show that transcription factor activating enhancer binding protein-4 (TFAP4) is a direct transcriptional target of MYCN in neuroblastoma and that high levels of this transcription factor are associated with poor clinical outcome in this disease.
Depletion of either Arl5b or AP4 results in the accumulation of APP.
results indicate that AP4 is a central mediator and coordinator of cell cycle progression
the 16 SNP variants studied in the genes encoding the four units of AP-4 do not have a major role in overall CP, but SNP rs1217401 of AP4B1 is significantly associated with the risk of CP as a sequela of neonatal HIE in the Chinese population.
betaTrCP-dependent degradation of TFAP4 is required for the fidelity of mitotic division
Senescence caused by AP4-deficiency was prevented by depletion of p16 and/or p21, demonstrating that these factors mediate senescence caused by AP4 loss.
Elevated AP4 expression in primary colorectal cancer (CRC) significantly correlated with liver metastasis and poor patient survival. Findings imply AP4 as a new regulator of epithelial-mesenchymal transition that contributes to metastatic processes in CRC
findings provide evidence that a high expression level of AP-4 serves as a biomarker for poor prognosis for hepatocellular carcinoma
The expression of AP-4 was silenced by the siRNAs transfection.
Overexpression of AP-4 is associated with gastric carcinoma.
in serum- or IGF-1-stimulated breast cancer MCF-7 cells, JNK induces SHP1 expression through the binding of AP-4 and RFX-1 transcription factors to the epithelial tissue-specific SHP1 promoter.
Activator protein-4 expression was associated with the expression of matrix metalloproteinase-9 and vascular endothelial growth factor in the advanced colorectal cancer.
Docking studies showed that the ATF4 DpSGIXXpSXE motif fits the binding pocket of beta-TrCP through an S-turning conformation.
Results establish Ap4 as rate-limiting mediator of adenoma initiation, as well as regulator of intestinal and colonic stem cell and Paneth cell homeostasis.
AP4 integrates T-cell-mediated selection and sustained expansion of GC B cells for humoral immunity.
Induction of AP4 by c-myc maintains CD8+ T cell activation.
AP4 contributes to Cd4 silencing both in DN and CD8(+) T cells by enforcing checkpoints for appropriate timing of CD4 expression and its epigenetic silencing.
caspase-9 expression is regulated by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988
transcription factor AP-4 (activating enhancer binding protein 4)
, transcription factor AP-4
, transcription factor AP4
, activating enhancer-binding protein 4
, class C basic helix-loop-helix protein 41
, transcription factor AP-4 (activating enhancer-binding protein 4)