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Dkkl1 may not be essential for normal brain organization, but could exert import functions during pathological conditions such as tumorigenesis and cancer progression.
DKKL1/Dkkl1 may play an important role in testicular development and spermatogenesis and may be an important factor in male infertility.
DKKL1 is a mammalian-specific acrosomal protein that is not essential either for development or fertility.
DKKL1 is a mammalian-specific, acrosomal protein that strongly affects in vitro fertilization, although the effect is attenuated in vivo.
Results suggest that DNA methylation is not the primary determinant of Soggy/Tead2 expression.
Dkkl1 is a negative regulator of adult testis homeostasis that specifically controls the number of postpubertal spermatocytes.
SLY1 interacts with acrosomal protein DKKL1, histone acetyltransferase KAT5 & microtubule-associated protein APPBP2; data suggest SLY1 may be involved in spermiogenesis processes, including control of gene expression & acrosome development or function
DKKL was overexpressed in colorectal cancer tissue compared with healthy colon. DKKL expression positively correlated with colorectal cancer progression.
previously unreported alternative splicing patterns in the genes ZNF419 and DKKL1
Findings suggest that Dkk-3 plays a role in the regulation of cell interactions during retinoic acid-induced neuronal differentiation; effect on apoptosis was also observed upon expression of the related protein Dkkl-1
Unliganded VDR upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 and SOSTDC1.
The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, dickkopf-like 1 (soggy)
, dickkopf-like protein 1
, protein soggy-1
, soggy 1
, cancer/testis antigen 34