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CCK1R may play a role differing from CCK2R in colon carcinogenesis, nuclear CCK1R represents a potential biomarker for poor prognosis.
Study shows downregulation of CCKAR gene expression in A1/A1 genotype of gallstone disease patients as compared with control with significant variation in its expression pattern in relation to polymorphism.
Our study showed significantly higher expression of CCKAR and down regulation of CCKBR in pancreatic cancer as compared to control while CCKBR/GR was detected in majority of stomach cancer samples. Thus, our study suggests that CCK and Gs receptors may have diagnostic and therapeutic implications.
The neurotransmitter cholecystokinin (CCK), along with its receptors, CCKAR and CCKBR, have been previously associated with psychiatric disorders, suggesting that variants near these genes may play a role in the pre-pulse/startle response in this cohort
CCK-AR polymorphism is protective against functional dyspepsia.
There is functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.
CCK binding modulates the contractile function of the lower esophageal sphincter through differential binding to the CCK-A receptor on the sling and clasp fibers
Age related differential expression of CCKAR in GBC may suggest two possible variants of the disease in this endemic belt.
Y140A mutation within a cholesterol-binding motif results in ligand binding and activity characteristics similar to wild type CCK1R. in a high cholesterol environment
The findings suggest that variants in the CCKAR gene may influence the risk of gallbladder cancer in women.
A significant association of the cholecystokinin-A receptor (CCKAR) gene variation rs1800857 and language lateralization, is reported.
The results showed that three individual haplotypes of CCKAR were strongly associated with increased risk of schizophrenia.
Data suggest that CCK-1R expression is up-regulated in kidney tubules (but not in glomeruli) in patients with diabetic nephropathy; increased expression of CCK-1R in tubules appears to be biomarker of severity of proteinuria in these patients.
data may suggest that the TM3 CRAC cholesterol-binding motif could be responsible for the cholesterol sensitivity of the CCK1R.
CCKAR expression was significantly increased in gallbladder cancer compared to gallstone disease.
Data indicate that the Homo-Phe derivative 2 (VL-0797) enhanced 12-fold the affinity for the rat CCK(1)-R affinity and 15-fold for the human CCK(1)-R relative to the reference compound 12 (VL-0395).
An association is not found between cholecystokinin A receptor polymorphisms and antipsychotic induced weight gain in schizophrenia patients.
LPS can up-regulate the expression of CCK-AR and CCK-BR mRNA in vascular endothelial cells.
Impaired muscle contraction in gallbladders with cholesterol stones is due to high caveolar levels of cholesterol that inhibits CAV-3 generation; cholesterol increases the caveolar sequestration of CAV-3 and CCK-1R.
a 2-marker haplotype (rs1800855/rs1800857) in the CCKAR gene protected women against PD (P=0.004). In addition, we found two novel rare missense variations in the CCKBR gene (Lys329Asn and Pro446Leu) in two and one patient, respectively
The studies establish chronic pancreatitis as an IL-33-dependent inflammation resulting from synergistic interactions between the NOD1 and CCKR signaling pathways.
mice lacking CCK receptors exhibited a functional shift from the gastrin-CCK pathways to the neuronal pathway in control of the ECL cells and eventually the acid secretion
cellular and subcellular localization of cholecystokinin (CCK)-1 receptors in the pancreas, gallbladder, and stomach
The lithogenic diet was associated with significantly lower CAV3 in the liver and lower CAV3 and CCKAR in the gallbladder compared with the control mice.
CCK-8S increases [Ca(2+)]i in gastric antral interstitial cells of Cajal via the CCK(1) receptor
CCK1 receptor activation does not have a greater effect combination with upregulated leptin signalling in high-fat-fed mice
Suggest role for ependymal CCK-1 receptors in infant satiety-controlling mechanisms.
CCK-1 and -2 receptors may function synergistically in single PaPo neurons and deletion of CCK-1 receptors may facilitate CCK-2 receptor signaling.
This study demonistrated that cholecystokinin-1 receptor relate to glucose homeostasis.
data show that hyperphagia in CCKR/ mice ingesting HF diet is reversed by blockade of the ghrelin receptor.
activation of neurons in the nucleus of the solitary tract following administration of T2R agonists to the GI tract involves CCK(1) and Y(2) receptors located on vagal afferent terminals in the gut wall [CCK1R]
CCK-A receptor is important for pancreatic exocrine secretion but not essential for maintaining glucose concentration and pancreatic growth in mice
Anxiety-related behaviors in cholecystokinin-A, B, and AB receptor gene knockout mice in the plus-maze.
Gallstone formation was enhanced in CCK-AR gene knockout mice.
Deteriorated gallbladder contraction due to a lack of CCK-AR favored gallstone formation after the middle age of life.
Differential roles for cholecystokinin a receptors in energy balance in rats and mice.
Mice without CCK-AR showed larger hysteresis than mice with CCK-AR.
CCKAR is involved in CCK-8S-induced depolarization of orexin neurons.
MEKK1 probably activates a transcriptional partner of c-Jun whose activity is maintained or increased in the presence of the rat cholecystokinin 1 receptor but repressed in the presence of the mouse cholecystokinin 1 receptor.
Sphincter of Oddi CCKAR expression levels increased in the cholesterol gallstone groups compared to the control group.
This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine.
, cholecystokinin B receptor
, cholecystokinin receptor
, cholecystokinin A receptor
, cholecystokinin receptor type A-like
, CCK-A receptor
, cholecystokinin receptor type A
, cholecystokinin type-A receptor
, cholecystokinin-1 receptor
, gastric cholecystokinin A receptor
, cholecystokinin 1 receptor
, Cholecystokinin receptor type A
, Cholecystokinin-1 receptor