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anti-Human GABBR1 Antibodies:
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Mammalian Monoclonal GABBR1 Primary Antibody for ISt, IHC - ABIN1304650
Karls, Mynlieff: GABAB receptors couple to Gαq to mediate increases in voltage-dependent calcium current during development. in Journal of neurochemistry 2015
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Human Monoclonal GABBR1 Primary Antibody for IF, RNAi - ABIN560976
Tse, Su, Chang, Tsang, Yu, Tang, See, Hsueh, Yang, Hao, Li, Wang, Liao, Chen, Lin, Jorgensen, Chang, Shugart: Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3. in American journal of human genetics 2009
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Human Polyclonal GABBR1 Primary Antibody for WB - ABIN152505
Fatemi, Folsom, Reutiman, Thuras: Expression of GABA(B) receptors is altered in brains of subjects with autism. in Cerebellum (London, England) 2009
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Human Polyclonal GABBR1 Primary Antibody for ELISA, ICC - ABIN6258814
Zhou, Chen, Liu, Manyande, Zhang, Yang, Xiong, Fu, Song, Rittner, Ye, Tian: The Role of Spinal GABAB Receptors in Cancer-Induced Bone Pain in Rats. in The journal of pain : official journal of the American Pain Society 2018
GABA B receptor expression in myometrium
Results show that pregnancy anxiety is associated with differential DNA methylation patterns in newborns and, reveal a potential role for GABBR1 methylation in association with stress in newborns.
GABAB receptor modulation in Periodontal Ligament cells might become an important target in immunoinflammatory settings.
There was no statistically significant association for the two SNPs of the GABBR1 gene (rs29230 and rs29267). However, a significant difference between AUD individuals and controls was observed at genotype level for rs2900512 of GABBR2 gene.
The combined analysis confirmed evidence of genome-wide significant associations in the Han Chinese population for three loci, at 2p16.1 (rs1051061, in an exon of VRK2, P=1.14 x 10-12, odds ratio (OR)=1.17), 6p22.1 (rs115070292 in an intron of GABBR1, P=4.96 x 10-10, OR=0.77) and 10q24.32 (rs10883795 in an intron of AS3MT, P=7.94 x 10-10, OR=0.87; rs10883765 at an intron of ARL3, P=3.06 x 10-9, OR=0.87).
Genotype and allele frequencies of rs29230 in GABR1 were significantly different between cases and controls, especially for male patients, for obstructive sleep apnea risk in Chinese Han population.
presynaptic gamma-aminobutyric acid type B receptor deficits contribute to altered neuronal excitability in fragile X syndrome
Results show that GABBR1 minor genotypes/alleles were protective against risk for alcoholism in 3 ethnically diverse cohorts.
Cell surface ubiquitination precedes endocytosis, after which USP14 acts as an ubiquitin-binding protein that targets the ubiquitinated GABA B receptor to lysosomal degradation and promotes its deubiquitination.
GABA(B)R stimulation promotes chemotaxis in RBL cells which is dependent on signaling via PI3-K/Akt, Src kinases and on rearrangement of both microtubules and actin cytoskeleton.
GABBR1 receptors are expressed in aortic smooth muscle cells and regulate the [Ca(2+)]i via a Gi/o-coupled receptor pathway and a phospholipase C activation pathway.
the first report of abnormal levels of GABA+ and Glx in mood-related brain regions of women with PMDD, indicating that dysregulation of the amino acid neurotransmitter system may be an important neurobiological mechanism in the pathogenesis of PMDD.
Chronic alcohol altered exon/intron expression and splice junction levels.
GABBR1 protein involved in phenylthiourea bitter taste detection.
The endoplasmic reticulum retention signal of GBR1 is not part of the core coiled-coil structure, suggesting that it is sterically shielded by GBR2 upon heterodimer formation.
Authors suggest GABBR1, GABA receptor B1, is implicated in schizophrenia based on a Human endogenous retrovirus long terminal repeat (HERV-W LTR) in the regulatory region of GABBR1.
GABA may inhibit the growth of cholangiocarcinoma QBC939 cells through the GABAB receptor, and the anti-cancer effects may be partly mediated via the JAK/STAT3 pathway
Activation of GABA(B) receptors significantly inhibits Akt/GSK-3 signaling in a beta-arrestin-dependent pathway.
We have discovered main triplets of amino acid residues in the GABAB1 receptor and several other neural receptors which seem to come from immunoglobulin chains and appear also as homologies in receptor heteromers.
Results show that GABA(B) receptors R1 and R2 must be activated for the modulation of N-type (Ca(v)2.2) calcium channels by analgesic alpha-conotoxins Vc1.1 and RgIA.
These data provide a better framework for understanding the different roles played by GABAB receptors and their effector ion channels in the cerebellar network.
These data suggest that GABA, acting through both presynaptic GABAA and GABAB receptors, modulate the amplitude and short-term plasticity of excitatory synapses, a result not possible from activation of either receptor type alone
This study showed that increase dorsal raphe GABA(B1a) expression via epigenetic regulation is associated with abnormal responses to social stimulation such as encounter-induced hyperactivity and aggressive behavior in isolation-reared mice
activation of presynaptic hippocampal GABAB receptors is important for acquisition of a learning task and for learning-associated synaptic changes and network dynamics.
These results suggest a role for GABAB receptor in Fmrp regulation and a potential interest of GABAB receptor signaling in Fragile X syndrome improvement.
Activation of GABA(B) or mGlu2/3 receptors inhibited both evoked presynaptic Ca(2+) transients and striatal field potentials.
Embryonic GABA-B receptor blockade alters cell migration, adult hypothalamic structure, and anxiety- and depression-like behaviors sex specifically in mice.
Immunoblotting and RT-PCR results showed that NIHL increased the expression of PKCgamma but decreased that of GABABR1 and GABABR2 at both protein and mRNA levels in the CNC
Results show GABA(B(1a,2)) and GABA(B(1b,2)) receptor subtypes differentially modulate Granule Cell outputs via selective axonal terminal and dendritic locations in the hilar pathways.
GABAB(1) receptor subunit isoforms differentially regulate the deleterious effects of stress and, thus, may be important therapeutic targets for the treatment of depression
Results establish an endogenous GABA/GABAB1 feedback mechanism that keeps TRPV1-mediated pain hypersensitivity in check.
The Gabbr1 has an important role in mediating the anxiety-related effects induced by nicotine.
The results of this study suggested a complex role for GABAB receptors in mediating neocortical circuit function.
Results show that GABAB(1a) receptors are required for the maintenance, but not encoding, of a precise fear memory; and are required for the maintenance, but not encoding, of spatial memories
The study suggested that the altered pain sensitivity derives from a Schwann cell-specific loss of GABA-B receptor functions, pointing to a role for GABA-B receptors in the regulation of Schwann cell maturation towards the non-myelinating phenotype.
Sex differences in reproductive genes Gnrh1, Gad1, and Kiss1 are critically disturbed in GABAB1-deficient mice, probably altering the organization and development of neural circuits governing the reproductive axis.
GABAB signaling may normally directly or indirectly inhibit Kiss1 expression, particularly in the bed nucleus of the stria terminalis and medial amygdala
Pharmacological inhibition of GABAB receptors stimulated neural stem cell proliferation and genetic deletion of GABAB1 receptor subunits increased neural stem cell proliferation and differentiation of neuroblasts in vivo.
Enhanced GABA B receptor activity reduces expression of Arg3.1, which is critical for long-term memory.
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic
, GABAB, subunit 1c
, gamma-aminobutyric acid type B receptor subunit 1
, seven transmembrane helix receptor
, gamma-aminobutyric acid (GABA) B receptor, 1
, gamma-aminobutyric acid (GABA) B receptor 1
, gamma-aminobutyric acid B receptor 1
, GABA-B receptor 1
, GABA-BR1b receptor
, bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a)
, gamma-aminobutyric acid (GABA-B) receptor, 1