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laryngeal cancer cells were enriched in the recurrent chimera COL7A1-UCN2, which potentially affected cancer stem cell transition
examination of the local and systemic cardiovascular effects of urocortin 2 and urocortin 3 in healthy subjects and patients with heart failure
Data show that corticotropin releasing hormone receptor 2 (Crhr2) protein is abundantly expressed in the heart, and plasma Ucn2 levels were higher in patients with heart failure compared to healthy controls, indicating that endogenous Crhr2 is associated with heart failure.
The transcripts of TAS1R3 and UCN2 in peripheral blood cells may be considered potential biomarkers of consumption of sugary and fatty food, respectively, to complement data of food-intake questionnaires.
up-regulated in placenta, fetal membranes, and myometrium in labor
Corticotrophin-Releasing Factor (CRF) and the urocortins are potent regulators of the inflammatory phenotype of human and mouse white adipocytes.
Stresscopin-related peptide induces a weaker enhancement of cardiovascular function through corticotropin-releasing factor receptorn 2 than that induced by stresscopin.
Solubilized SUMO-eXact-preproUCN2 was used successfully to generate two high affinity mouse monoclonal antibodies specific to the pro-region of urocortin 2.
UCN2 is significantly associated with AAA and inhibits VSMC proliferation by inducing a G1 cell cycle arrest suggesting a plausible regulatory role in AAA pathogenesis
UCNII caused cell death via different membrane-disrupting mechanisms that involve aggregation & membrane depolarization in bacteria and pore formation in Leishmania even inside macrophages. Innate immune cells produce UCNII in response to infections.
Description of ucn2 posttranslational processing and peptide sequence. Hypoxia and glycosylation, paradigms that might influence secretion or processing of gene products, did not significantly impact hUcn 2 prohormone cleavage.
study showed that Ucn2 and Ucn3 differentially regulate the LPS-induced TNF-alpha and IL-10 expression and secretion in trophoblast explants acting through CRH-R2. Ucn2 is proinflammatory.
These data suggest a possible involvement of urocortin 2 and Ucn 3 in the mechanisms of endometriosis.
Confirm the anti-inflammatory function of VIP, through the modulation of the expression of CRF system that impacts in a reduction of mediators with inflammatory/destructive functions.
Unlike urocortin-1 levels, higher levels of urocortin 2 are not associated with worse left ventricular diastolic performance in patients with chronic systolic heart failure.
Urocortin 2 may play a role in the regulation of estradiol production throughout pregnancy, thereby contributing to the placental regulation of key reproductive events in pregnancy maintenance and parturition.
Placental Ucn2 and Ucn3 expression is sensitive to O(2) tensions and mediated by HIF-1alpha. In preeclampsia, the increased expression of both peptides may reflect a response to the oxidative stress.
SCP and UCN are potent activators of the p42/44 MAPK pathway, with SRP able to induce phosphorylation of p42/44 MAPK as well, albeit not as pronounced
data suggest a distinctive role for corticotropin-releasing hormone receptor 2 specific agonists like urocortin II in the control of myometrial contractility during human pregnancy
data indicate that intracisternal Ucn 2 induced a central CRF(2)-mediated inhibition of gastric emptying involving sympathetic alpha(1)-adrenergic mechanisms independent from the vagus contrasting with the vagal-dependent inhibitory actions of CRF & Ucn 1
Urocortin 2 acts on gonadotrophs expressing the corticotropin-releasing factor type 2 receptor, and inhibits the production of gonadotropins in the pituitary gonadotropic tumor cells.
Co-administration of neutralizing interleukin-6 receptor antibodies (0.2 mg kg(-1) ) and corticotrophin-releasing factor receptor 2 agonist.
results indicate that long-term UVA eye irradiation led to increased gp91phox-derived ROS in the brain and the increased expression of urocortin 2 and CRHR type 2, resulting in photoaging; however, further studies are needed to confirm these findings
This study aims to investigate the cellular localization of CRF and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation.
increased significantly in placenta approaching birth
Leptin regulates corticotropin-releasing factor and urocortin 2/3 mRNA in hypothalamic neurons.
Urocortin 2 autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase in the heart.
this study demonistrated that male UCN2 null mice showed more passive social interactions.
Ucn2 can modulate GnRH mRNA levels
CRF(1) agonists, Ucn 1 and stressin(1) -A, reduced feeding and induced interoceptive stress, whereas Ucn 2 potently suppressed feeding via a CRF(2) -dependent mechanism without eliciting malaise
findings suggest an important role for UCN2 in cardiovascular homeostasis
Ucn II is expressed in the hypothalamus, brainstem, olfactory bulb, and pituitary. Low levels were also detected in the mouse cortex, hippocampus, and spinal cord, Ucn II gene transcription was stimulated by glucocorticoids
CRFR2beta selective Ucn-II or Ucn-III will protect cardiomyocytes and the ex vivo Langendorff perfused rat heart from ischemia reperfusion injury by activation of ERK1/2-p42, 44.
significant increase in urocortin II mRNA levels in the skin, but not in skeletal muscle, of both corticotropin-releasing factor receptor 1 and 2-null mice
Urocortin 2 induces macrophage apoptosis via Corticotropin-Releasing Factor Receptor-2.
The differential phenotype of urocortin 2 deficiency in female and male mice may imply a role for urocortin 2 in these gender differences.
Ucn 2 inhibited insulin-induced Akt and ERK1/2 phosphorylation in cultured skeletal muscle cells and C2C12 myotubes
The selective CRF2 agonist prevented enhanced defecation.
the Ucn-CRH receptor system may be regulated by two major forms of cardiac stresses, i.e. oxidative and inflammatory stress, and may play a critical role in cardiac stress adaptation in heart diseases
no effects on ciliary muscle's resting force
member of the corticotropin-releasing hormone (CRH)-related peptides\; may play a role in cardiac hypertrophy and fibrosis\; promotes cell proliferation of cardiac non-myocytes
, urocortin 3
, urocortin II
, prepro-urocortin 2
, stresscopin-related peptide
, urocortin-related peptide
, Urocortin II
, urocortin 2