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examination of the local and systemic cardiovascular effects of urocortin 2 and urocortin 3 (show UCN3 Antibodies) in healthy subjects and patients with heart failure
Data show that corticotropin releasing hormone receptor 2 (Crhr2 (show CRHR2 Antibodies)) protein is abundantly expressed in the heart, and plasma Ucn2 (show UTS2 Antibodies) levels were higher in patients with heart failure compared to healthy controls, indicating that endogenous Crhr2 (show CRHR2 Antibodies) is associated with heart failure.
The transcripts of TAS1R3 (show TAS1R3 Antibodies) and UCN2 (show UTS2 Antibodies) in peripheral blood cells may be considered potential biomarkers of consumption of sugary and fatty food, respectively, to complement data of food-intake questionnaires.
Corticotrophin-Releasing Factor (show CRH Antibodies) (CRF (show CRH Antibodies)) and the urocortins are potent regulators of the inflammatory phenotype of human and mouse white adipocytes.
Stresscopin-related peptide induces a weaker enhancement of cardiovascular function through corticotropin-releasing factor (show CRH Antibodies) receptorn 2 than that induced by stresscopin (show UCN3 Antibodies).
Solubilized SUMO-eXact-preproUCN2 was used successfully to generate two high affinity mouse monoclonal antibodies specific to the pro-region of urocortin 2.
UCN2 (show UTS2 Antibodies) is significantly associated with AAA (show APP Antibodies) and inhibits VSMC proliferation by inducing a G1 cell cycle arrest suggesting a plausible regulatory role in AAA (show APP Antibodies) pathogenesis
UCNII caused cell death via different membrane-disrupting mechanisms that involve aggregation & membrane depolarization in bacteria and pore formation in Leishmania even inside macrophages. Innate immune cells produce UCNII in response to infections.
Description of ucn2 (show UTS2 Antibodies) posttranslational processing and peptide sequence. Hypoxia and glycosylation, paradigms that might influence secretion or processing of gene products, did not significantly impact hUcn 2 prohormone cleavage.
study showed that Ucn2 (show UTS2 Antibodies) and Ucn3 (show UCN3 Antibodies) differentially regulate the LPS (show IRF6 Antibodies)-induced TNF-alpha (show TNF Antibodies) and IL-10 (show IL10 Antibodies) expression and secretion in trophoblast explants acting through CRH-R2 (show CRHR2 Antibodies). Ucn2 (show UTS2 Antibodies) is proinflammatory.
Urocortin 2 (show UTS2 Antibodies) acts on gonadotrophs expressing the corticotropin-releasing factor (show CRH Antibodies) type 2 receptor, and inhibits the production of gonadotropins in the pituitary gonadotropic tumor cells.
Co-administration of neutralizing interleukin-6 receptor (show IL6R Antibodies) antibodies (0.2 mg kg(-1) ) and corticotrophin-releasing factor (show CRH Antibodies) receptor 2 agonist.
results indicate that long-term UVA eye irradiation led to increased gp91phox (show CYBB Antibodies)-derived ROS (show ROS1 Antibodies) in the brain and the increased expression of urocortin 2 (show UTS2 Antibodies) and CRHR (show CRHR1 Antibodies) type 2, resulting in photoaging; however, further studies are needed to confirm these findings
This study aims to investigate the cellular localization of CRF (show CRH Antibodies) and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation.
Leptin (show LEP Antibodies) regulates corticotropin-releasing factor (show CRH Antibodies) and urocortin 2 (show UTS2 Antibodies)/3 mRNA in hypothalamic neurons.
Urocortin 2 (show UTS2 Antibodies) autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase (show PRKAA2 Antibodies) in the heart.
this study demonistrated that male UCN2 (show UTS2 Antibodies) null mice showed more passive social interactions.
Ucn2 can modulate GnRH mRNA levels
CRF(1) agonists, Ucn 1 and stressin(1) -A, reduced feeding and induced interoceptive stress, whereas Ucn 2 potently suppressed feeding via a CRF(2) -dependent mechanism without eliciting malaise
member of the corticotropin-releasing hormone (CRH)-related peptides\; may play a role in cardiac hypertrophy and fibrosis\; promotes cell proliferation of cardiac non-myocytes
, urocortin 3
, urocortin II
, prepro-urocortin 2
, stresscopin-related peptide
, urocortin-related peptide
, Urocortin II
, urocortin 2