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examination of the local and systemic cardiovascular effects of urocortin 2 and urocortin 3 (show UCN3 Proteins) in healthy subjects and patients with heart failure
Data show that corticotropin releasing hormone receptor 2 (Crhr2 (show CRHR2 Proteins)) protein is abundantly expressed in the heart, and plasma Ucn2 (show UTS2 Proteins) levels were higher in patients with heart failure compared to healthy controls, indicating that endogenous Crhr2 (show CRHR2 Proteins) is associated with heart failure.
The transcripts of TAS1R3 (show TAS1R3 Proteins) and UCN2 (show UTS2 Proteins) in peripheral blood cells may be considered potential biomarkers of consumption of sugary and fatty food, respectively, to complement data of food-intake questionnaires.
Corticotrophin-Releasing Factor (show CRH Proteins) (CRF (show CRH Proteins)) and the urocortins are potent regulators of the inflammatory phenotype of human and mouse white adipocytes.
Stresscopin-related peptide induces a weaker enhancement of cardiovascular function through corticotropin-releasing factor (show CRH Proteins) receptorn 2 than that induced by stresscopin (show UCN3 Proteins).
Solubilized SUMO-eXact-preproUCN2 was used successfully to generate two high affinity mouse monoclonal antibodies specific to the pro-region of urocortin 2.
UCN2 (show UTS2 Proteins) is significantly associated with AAA (show APP Proteins) and inhibits VSMC proliferation by inducing a G1 cell cycle arrest suggesting a plausible regulatory role in AAA (show APP Proteins) pathogenesis
UCNII caused cell death via different membrane-disrupting mechanisms that involve aggregation & membrane depolarization in bacteria and pore formation in Leishmania even inside macrophages. Innate immune cells produce UCNII in response to infections.
Description of ucn2 (show UTS2 Proteins) posttranslational processing and peptide sequence. Hypoxia and glycosylation, paradigms that might influence secretion or processing of gene products, did not significantly impact hUcn 2 prohormone cleavage.
study showed that Ucn2 (show UTS2 Proteins) and Ucn3 (show UCN3 Proteins) differentially regulate the LPS (show IRF6 Proteins)-induced TNF-alpha (show TNF Proteins) and IL-10 (show IL10 Proteins) expression and secretion in trophoblast explants acting through CRH-R2 (show CRHR2 Proteins). Ucn2 (show UTS2 Proteins) is proinflammatory.
findings collectively suggest that the MeA (show MEA1 Proteins) Ucn3 (show UCN3 Proteins)-CRF-R2 (show CRHR2 Proteins) system modulates the ability of mice to cope with social challenges
results indicate that long-term UVA eye irradiation led to increased gp91phox (show CYBB Proteins)-derived ROS (show ROS1 Proteins) in the brain and the increased expression of urocortin 2 (show UTS2 Proteins) and CRHR (show CRHR1 Proteins) type 2, resulting in photoaging; however, further studies are needed to confirm these findings
Ucn3 (show UCN3 Proteins) KO mice displayed significantly increased ethanol intake and preference compared with WT. There were no long-term effects of chronic pain on alcohol drinking behavior, regardless of genotype.
This study aims to investigate the cellular localization of CRF (show CRH Proteins) and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation.
The paracrine actions of Ucn3 (show UCN3 Proteins) activate a negative feedback loop that promotes somatostatin (show SST Proteins) release to ensure the timely reduction of insulin (show INS Proteins) secretion upon normalization of plasma glucose.
UCN3 (show UCN3 Proteins) expression enhances glucose disposal and signalling in muscle by an autocrine/paracrine mechanism that is separate from its pro-hypertrophic effects.
Leptin (show LEP Proteins) regulates corticotropin-releasing factor (show CRH Proteins) and urocortin 2 (show UTS2 Proteins)/3 mRNA in hypothalamic neurons.
Urocortin 2 (show UTS2 Proteins) autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase (show PRKAA2 Proteins) in the heart.
this study demonistrated that male UCN2 (show UTS2 Proteins) null mice showed more passive social interactions.
member of the corticotropin-releasing hormone (CRH)-related peptides\; may play a role in cardiac hypertrophy and fibrosis\; promotes cell proliferation of cardiac non-myocytes
, urocortin 2
, prepro-urocortin 2
, stresscopin-related peptide
, ucn II
, urocortin II
, urocortin-related peptide
, Urocortin II
, urocortin 3
, Urocortin III
, ucn III