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Genetic variants in NBA1 may be an important genetic determinant of triple-negative breast cancer susceptibility.
MERIT40 interacts with ABRAXAS which is adaptor molecule of BRCA1-complex.
findings suggest that germline deleterious mutations in C19orf62 should be rare or absent in familial and nonfamilial breast cancer women
NBA1/MERIT40 and BRE (show BRE Proteins) interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36 (show BRCC3 Proteins)-containing complexes
Single nucleotide polymorphism in MERIT40 is associated with ovarian cancer.
germline mutations in MERIT40 are rare or absent in familial breast cancer patients.
MERIT40 represents a novel factor that links BRCA1-Rap80 complex integrity, DSB recognition, and ubiquitin chain hydrolytic activities to the DNA damage response.
A stable complex containing MERIT40 acts early in DNA damage response and regulates damage-dependent BRCA1 localization.
NBA1 is required to maintain BRE and Abra1 abundance and for the recruitment of BRCA1 to sites of DNA damage. In depth bioinformatics analysis revealed that the BRCA1 A complex bears striking similarities to the 19S proteasome complex.
Merit40 mutation exacerbated ICL-induced chromosome instability in the context of concomitant Brca2 deficiency but not in conjunction with Fancd2 mutation.
MERIT40(-/-) hematopoietic stem cells are more resistant to cytoablative stress, and exhibit superior repopulating ability and self-renewal upon serial transplantation.
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component (By similarity).
BRCA1-A complex subunit MERIT40
, BRISC and BRCA1-A complex member 1
, mediator of RAP80 interactions and targeting subunit of 40 kDa
, new component of the BRCA1-A complex
, mediator of Rap80 interactions and targeting 40 kDa
, new component of the BRCA1 A complex
, new component of the BRCAA1 A complex
, Uncharacterized protein C19orf62 homolog