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Human Polyclonal UBE2V2 Primary Antibody for ELISA, WB - ABIN249511
Fritsche, Rehli, Krause, Andreesen, Kreutz: Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes. in Biochemical and biophysical research communications 1997
Data suggest that ubiquitin-conjugating enzyme E2 variant 2 (Ube2V2) and ring finger protein 4 (RNF4 (show RNF4 Antibodies)) together induce an active conformation of the ubiquitin-conjugating enzyme (show Ube2t Antibodies) Ubc13 (show UBE2N Antibodies)-ubiquitin (Ubc13 (show UBE2N Antibodies)~Ub) thioester.
Functional analysis of selected regulated proteins revealed that knockdown of HNRPD (show HNRNPD Antibodies), PHB2 (show PHB2 Antibodies) and UB2V2 can increase HCMV replication, while knockdown of A4 and KSRP (show KHSRP Antibodies) resulted in decreased HCMV replication.
Data show RING finger (show PCGF1 Antibodies) (RNF (show TRIM31 Antibodies)) E3 ubiquitin ligase (show MUL1 Antibodies) RNF8 (show RNF8 Antibodies) dimerizes and binds to E2 ubiquitin-conjugating complex Ubc13 (show UBE2N Antibodies)/Mms2 with formation of Lys (show LYZ Antibodies)-63 ubiquitin chains, whereas the RNF168 (show RNF168 Antibodies) RING domain is a monomer and does not catalyze Lys (show LYZ Antibodies)-6 ubiquitylation.
the crystal structure of human OTUB1 (show OTUB1 Antibodies) in complex with human UBC13 (show UBE2N Antibodies) and MMS2
entire coding region and splice junctions of RNF8 (show RNF8 Antibodies), UBC13 (show UBE2N Antibodies) and MMS2 genes were screened for mutations in affected index cases from 123 Northern Finnish breast cancer families
Ubc13 (show UBE2N Antibodies)-Mms2 and Lys63-polyubiquitin (show UBB Antibodies) chains are associated with signaling cellular stress
UBE2v2 signalling through PCNA (show PCNA Antibodies) ubiquitination is not required for immunoglobulin diversification in DT40 cells.
The results in this study allowed identification of important residues of the Ubc13 (show UBE2N Antibodies)-Mms2 interface, determine a correlation between heterodimer formation and function, and conclude why Mms2 forms a specific complex with Ubc13 (show UBE2N Antibodies) but not other Ubc (show RPS27A Antibodies) proteins.
Insight into the influence of protein dynamics on the affinity of ubiquitin for Mms2.
Data demonstrate that divergent activities of Ubc13 (show UBE2N Antibodies) rely on its pairing with either of two Uevs, Uev1A (show UBE2V1 Antibodies) or Mms2.
Ang II (show AGT Antibodies) type 2 receptor signaling attenuates DNA damage and consequent vascular senescence at least in part through methyl methanesulfonate sensitive 2 (MMS2) transactivation.
Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes.
1 alpha,25-dihydroxyvitamin D3-inducible
, DDVit 1
, MMS2 homolog
, enterocyte differentiation promoting factor
, enterocyte differentiation-associated factor 1
, enterocyte differentiation-associated factor EDAF-1
, enterocyte differentiation-promoting factor 1
, methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of
, vitamin D3-inducible protein
, ubiquitin-conjugating enzyme E2v2
, ubiquitin-conjugating enzyme variant MMS2
, methyl methanesulfonate sensitive 2
, ubc-like protein MMS2
, ubiquitin-conjugating enzyme E2 variant 2
, Ubiquitin-conjugating enzyme E2 variant 2
, TMEM189-UBE2V1 readthrough transcript