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Human MCM3AP Protein expressed in Wheat germ - ABIN1310551
Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia. in Journal of immunological methods 2011
The identification of MCM3AP variants in affected individuals from multiple centres establishes it as a disease gene for childhood-onset recessively inherited Charcot-Marie-Tooth neuropathy with intellectual disability.
MCM3AP and POMP (show POMP Proteins) Mutations Cause a DNA-Repair and DNA-Damage-Signaling Defect in an Immunodeficient Child
These results indicated that the GANP protein is associated with breast cancer resistance.
GANP is induced in activated T4 cells & physically interacts with A3G. GANP is encapsidated in HIV-1 virions & modulates A3G packaging into the cores. Upregulation increases A3G-catalyzed viral G-->A hypermutation, suppressing infectivity.
A homozygous potentially pathogenic variant (c.2743G>A) was identified, which encodes amino acid Lys (show LYZ Proteins), instead of conserved Glu (show DCTN1 Proteins), at the position 915, in patients with mild intellectual disability.
GANP-mediated chromatin modification promotes transcription complex recruitment and positioning at immunoglobulin variable loci to favour AID targeting.
The cellular protein MCM3AP is required for inhibition of cellular DNA synthesis by the IE86 protein of human cytomegalovirus.
HBV DNA integration sites into human genome were random, and MCM3AP was a new site.
GANP, a homologue of yeast Sac3 that is involved in mRNA export, is indispensable for ensuring the stability of human genomic DNA and GANP knockdown causes apoptosis and necrosis of p53 (show TP53 Proteins)-insufficient cancer cells.
GANP transgene may play a critical role in Lyn tyrosine-protein kinase-mediated signaling during selection of high-affinity B cells in peripheral lymphoid organs.
GANP plays a positive role in IgV region diversification of DT40 B cells in a nonhomologous end joining-proficient state. DNA-PKcs (show PRKDC Proteins) physically interacts with GANP, and this interaction is dissociated by dsDNA breaks
GANP may serve as an essential link required to transport AID to B (show TDO2 Proteins)-cell nuclei and to target AID to actively transcribed IgV regions
interaction with MCM3 (show MCM3 Proteins) is associated with a novel phosphatase component G5PR (show PPP2R3C Proteins)
GANP(hi)plasma-like cells appear in lymph nodes of autoimmune mice during aging
Decreased expression of germinal center-associated protein (GANP) in Lyn (show LYN Proteins) kinase-deficient mice suggests that Lyn (show LYN Proteins) controls the formation and proliferation of germinal centers via GANP.
GANP is involved in V region alteration generating high-affinity Ab.
GANP has a critical role in suppression of DNA hyper-recombination in mammalian cells
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization.
80 kDa MCM3-associated protein
, minichromosome maintenance deficient 3 associated protein
, minichromosome maintenance complex component 3 associated protein
, minichromosome maintenance protein 3 associated protein
, MCM3 minichromosome maintenance deficient 3 associated protein
, 80 kDa MCM3-associated protein-like
, MCM3 import protein
, germinal center-associated nuclear protein
, germinal-centre associated nuclear protein
, minichromosome maintenance deficient 3-associated protein
, nuclear protein GANP