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protooncogene PBF is a negative regulator of p53 (show TP53 Proteins) function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 (show TP53 Proteins) mutations are rare compared with other tumor types
Nnegative pituitary tumor-transforming gene 1 protein-interacting protein (PTTG1IP) immunoexpression predicted a 1.5-fold risk of breast cancer death.
data reveal new insight into PBF function and confirm that, rather than being oncogenic, mutations in PBF are likely to be passenger effects, with overexpression of PBF the more important etiological event in human cancer
PTTG1IP and MAML3 are associated with BHR severity in adult asthma. The relevance of these genes is supported by the eQTL analyses and co-expression of PTTG1lP with vimentin and E-cadherin1, and MAML3 with MAML2.
Findings indicate that PBF and PTTG (show PTTG1 Proteins) have a critical role in promoting thyroid cancer that is predictive of poorer patient outcome.
Unique role for PBF in regulating CTTN (show CTTN Proteins) function to promote endocrine cell invasion and migration.
these results demonstrate an emerging role for PBF in colorectal tumorigenesis through regulating p53 (show TP53 Proteins) activity, with implications for PBF as a prognostic indicator for invasive tumors.
These findings indicate that miR (show MLXIP Proteins)-584 suppresses glioma cell growth by negatively regulating the expression of PTTG1IP, suggesting that miR (show MLXIP Proteins)-584 has a tumor suppressive role in human glioma pathogenesis.
Data from mutant recombinant proteins suggest that proto-oncogene PBF is a phosphoprotein and highlight importance of tyrosine residue Y174 in both endocytosis of PBF and its interaction/co-localization with NIS/SLC5A5 (sodium-iodide symporter).
PBF expression may be a promising biomarker for prognostic and therapeutic purposes in papillary thyroid carcinoma patients.
The encoded protein, which directly binds to pituitary tumor-transforming gene 1 protein (PTTG1), facilitates the nuclear translocation of PTTG1 and potentiates the transcriptional activation of basic fibroblast growth factor by PTTG1. The gene product localizes to both the cytoplasm and nucleus. Its NLS is required for its own nuclear localization, the nuclear localization of PTTG1, and its interaction with PTTG1.
, PTTG-binding factor
, pituitary tumor-transforming gene 1 protein-interacting protein
, pituitary tumor-transforming gene protein-binding factor