NFKB Inhibitor Interacting Ras-Like 1 (NKIRAS1) (AA 1-192) protein (His tag)

Details for Product No. ABIN6386901
Protein Name
Protein Characteristics
AA 1-192
5
1
Origin
Human
5
1
1
1
Source
Escherichia coli (E. coli)
4
2
1
1
Protein Type
Recombinant
Purification tag / Conjugate
His tag
Application
SDS-PAGE (SDS)
Options
Characteristics NKIRAS1, 1-192aa , Human, His tag, E.coli
Purity > 95 % by SDS - PAGE
Protein Name
Background NKIRAS1, also known as NF-kappa-B inhibitor-interacting Ras-like protein 1, belongs to the small GTPase superfamily. NKIRAS1 is atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. It may act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Recombinant human NKIRAS1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: NF-kappa-B inhibitor-interacting Ras-like protein 1, kappaB-Ras1, KBRAS1. NCBI no.: NP_065078
Molecular Weight 23.8 kDa (212aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/ml (determined by Bradford assay)
Buffer Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT
Storage 4 °C
Supplier Images
Image no. 1 for NFKB Inhibitor Interacting Ras-Like 1 (NKIRAS1) (AA 1-192) protein (His tag) (ABIN6386901) NFKB Inhibitor Interacting Ras-Like 1 (NKIRAS1) (AA 1-192) protein (His tag) (Image 1)
Image no. 2 for NFKB Inhibitor Interacting Ras-Like 1 (NKIRAS1) (AA 1-192) protein (His tag) (ABIN6386901) NFKB Inhibitor Interacting Ras-Like 1 (NKIRAS1) (AA 1-192) protein (His tag) (Image 2)