TYMS Protein (AA 1-313) (His tag)

Catalog No. ABIN666924

Product Details

Target: TYMS (Thymidylate Synthetase (TYMS))

Protein Type: Recombinant

Protein Characteristics: AA 1-313

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This TYMS protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Characteristics: Thymidylate synthase, 1-313aa, Human, His tag, E.coli

Purity: > 95 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1 M NaCl.

Storage: 4 °C

Target Details

Target: TYMS (Thymidylate Synthetase (TYMS))

Alternative Name: Thymidylate synthase (TYMS Products)

Target Type: Viral Protein

Background: Thymidylate synthase is an intracellular enzyme critical for de novo synthesis of DNA. This function maintains the dTMP(thymidine-5-prime monophosphate) pool critical for DNA replication and repair. In cancer, expression of this protein is often elevated and becomes further elevated as a result of treatment with the most commonly used chemotherapeutic, 5-fluorouracil (5-FU). Resistance or lack of response to 5-FU is attributed to the elevation of thymidylate synthase activity. Recombinant human Thymidylate synthase protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: HST422, TMS, TS, d TMP synthase, EC 2.1.1.45, MGC88736, Thymidylate synthase, Thymidylate synthetase, Tsase, TYMS, TYMS protein, Tyms thymidylate synthetase,. NCBI no.: NP_001062

Molecular Weight: 37.8 kDa (333aa), confirmed by MALDI-TOF.

Pathways: Mitotic G1-G1/S Phases