Peroxiredoxin 5 Protein (PRDX5) (His tag)

Catalog No. ABIN7320236

Product Details

Target: Peroxiredoxin 5 (PRDX5)

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Peroxiredoxin 5 protein is labelled with His tag.

Purpose: Recombinant Mouse Peroxiredoxin 5/PRDX5 Protein (His Tag)(Active)

Sequence: Met 49-Leu 210

Characteristics: A DNA sequence encoding the mouse PRDX5 (mitochondrial) (P99029-1) (Met 49-Leu 210) was expressed, with a polyhistide tag at the N-terminus.

Purity: > 92 % as determined by SDS-PAGE

Biological Activity Comment: Measured by its ability to reduce H2O2.The specific activity is > 100 pmoles/min/μg.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.5

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Peroxiredoxin 5 (PRDX5)

Alternative Name: Peroxiredoxin 5/PRDX5 (PRDX5 Products)

Background:

Background: Peroxiredoxin-5, also known as Alu corepressor 1, Antioxidant enzyme B166, Liver tissue 2D-page spot 71B, Peroxisomal antioxidant enzyme, Thioredoxin peroxidase PMP20, Thioredoxin reductase, PRDX5 and ACR1, is cytoplasm protein which belongs to the?peroxiredoxin 2 family. Peroxiredoxin-5 / PRDX5 reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Peroxiredoxin-5 / PRDX5 is involved in intracellular redox signaling. The Peroxiredoxins / Prx are a family of 25 kDa peroxidases that can reduce H2O2 using an electron from thioredoxin (Trx) or other substances. The mammalian Peroxiredoxins / Prx family is divided into six groups ( PRDX1,PRDX2, PRDX3, PRDX4, PRDX5, PRDX6 ) on the basis of homology of amino acid sequences. They are located in the cytosol and play a role in the cell signaling system. All six mammalian peroxiredoxins are expressed in the lung. Peroxiredoxins / Prx is overexpressed in breast cancer tissues to a great extent suggesting that Peroxiredoxins / Prx has a proliferative effect and may be related to cancer development or progression.

Synonym: AOEB166,AOPP,Pmp20,Prdx6,PrxV

Molecular Weight: 18.5 kDa

Pathways: Cell RedoxHomeostasis