Integrin alpha L beta 2 (ITGAL & ITGB2) Heterodimer (AA 24-1087) protein (His tag)
Origin: Mouse
Host: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
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- Target
- Integrin alpha L beta 2 (ITGAL & ITGB2) Heterodimer
- Protein Type
- Recombinant
- Protein Characteristics
- AA 24-1087
- Origin
- Mouse
- Source
- HEK-293 Cells
- Purification tag / Conjugate
- His tag
- Purpose
- Mouse Integrin alpha L beta 2 (ITGAL & ITGB2) Heterodimer Protein
- Sequence
- Tyr24-His1087 (ITGAL) acidic tail & Gln24-Asn702 (ITGB2) basic tail
- Specificity
- Uni-Prot: P24063-1 (ITGAL), P11835 (ITGB2)
- Characteristics
- Recombinant Mouse Integrin alpha L beta 2 (ITGAL & ITGB2) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains (ITGAL) & (ITGB2).
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Integrin alpha L beta 2 (ITGAL & ITGB2) Heterodimer
- Background
- Integrin αLβ2 is one member of the integrin family and also called leukocyte function-associated antigen-1 (LFA-1). It is widely expressed on T lymphocytes and controls the function and, in particular, the migration of immune cells[1]. Active αLβ2 can bind ICAM-1/CD54, ICAM-2, ICAM3 and JAM-1[2].
- Molecular Weight
- 123.30 kDa(ITGAL)&79.60 kDa(ITGB2). Due to glycosylation, the protein migrates to 160-180 kDa(ITGAL)&90-105 kDa(ITGB2) based on Tris-Bis PAGE result.
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