CXCR3 Protein-VLP
Quick Overview for CXCR3 Protein-VLP (ABIN7488804)
Target
See all CXCR3 ProteinsProtein Type
Origin
Source
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Purpose
- Human CXCR3 Full Length Protein (VLP)
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Sequence
- Val 2 - Leu 368
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Characteristics
- Human CXCR3 Full Length Protein-VLP is expressed from human 293 cells (HEK293). It contains AA Val 2 - Leu 368 (Accession # P49682-1).
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Endotoxin Level
- 1.0 EU per μg
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Chemokine (C-X-C Motif) Receptor 3 (CXCR3) (AA 1-53) protein (mFc Tag)
CXCR3 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Chemokine (C-X-C Motif) Receptor 3 (CXCR3) (AA 1-367) protein (His tag)custom-made CXCR3 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Chemokine (C-X-C Motif) Receptor 3 (CXCR3) (AA 1-368) protein (His tag)custom-made CXCR3 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Chemokine (C-X-C Motif) Receptor 3 (CXCR3) (AA 1-53) protein (Fc Tag)CXCR3 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Chemokine (C-X-C Motif) Receptor 3 (CXCR3) proteinCXCR3 Origin: Human Host: HEK-293 Cells Synthetic Nanodisc
Chemokine (C-X-C Motif) Receptor 3 (CXCR3) (AA 1-368) protein (GST tag)CXCR3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Chemokine (C-X-C Motif) Receptor 3 (CXCR3) (AA 1-53) protein (GST tag)CXCR3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Chemokine (C-X-C Motif) Receptor 3 (CXCR3) (AA 121-220) protein (GST tag)CXCR3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- PBS, Arginine, pH 7.4
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Storage
- -80 °C
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Storage Comment
- -70°C
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- CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))
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Alternative Name
- CXCR3
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Background
- Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells, and cause tissue extravasation. Given these properties, their role in anti-tumor immune response in the cancer environment is of great interest. Although immunotherapy has shown clinical benefit for some cancer patients, other patients do not respond. One of the mechanisms of resistance to checkpoint inhibitors may be chemokine signaling. The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis). However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis). Thus, a better understanding of CXCL9, -10, -11/CXCR3 axis is necessary to develop effective cancer control.
Target
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