ING3 Protein (AA 1-421) (His tag)

Catalog No. ABIN7564758

Product Details

Target: ING3 (Inhibitor of Growth Family, Member 3 (ING3))

Protein Type: Recombinant

Protein Characteristics: AA 1-421

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This ING3 protein is labelled with His tag.

Purpose: Made-to-order recombinant Ing3 Protein expressed in mammalian cells.

Sequence: MLYLEDYLEM IEQLPMDLRD RFTEMREMDL QVQNAMDQLE QRVSEFFMNA KKNKPEWREE QMASIKKDYY KALEDADEKV QLANQIYDLV DRHLRKLDQE LAKFKMELEA DNAGITEILE RRSLELDAPS QPVNNHHAHS HTPVEKRKYN PTSHHAAADH IPEKKFKSEA LLSTLTSDAS KENTLGCRNN NSTASCNNAY NVNSSQPLAS YNIGSLSSGA GAGAITMAAA QAVQATAQMK EGRRTSSLKA SYEAFKNNDF QLGKEFSIPR ETAGYSSSSA LMTTLTQNAS SSATDSRSGR KSKNNTKSSS QQSSSSSSSS SSSSLSLCSS SSTVVQEVSQ QATVVPESDS NSQVDWTYDP NEPRYCICNQ VSYGEMVGCD NQDCPIEWFH YGCVGLTEAP KGKWFCPQCT AAMKRRGSRH K Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: ING3 (Inhibitor of Growth Family, Member 3 (ING3))

Alternative Name: Ing3 (ING3 Products)

Background: Inhibitor of growth protein 3 (p47ING3),FUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). {ECO:0000250}.

Molecular Weight: 46.8 kDa

UniProt: Q8VEK6

AlphaFold: Q8VEK6