FARP2 Protein (AA 1-1065) (His tag)

Catalog No. ABIN7564787

Product Details

Target: FARP2 (FERM, RhoGEF and Pleckstrin Domain Protein 2 (FARP2))

Protein Type: Recombinant

Protein Characteristics: AA 1-1065

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This FARP2 protein is labelled with His tag.

Purpose: Custom-made recombinant Farp2 Protein expressed in mammalian cells.

Sequence: MGEIEGTYRA LPTSGTRLGG QTAIGVSTLE PEQSLSPRMQ EKHMRIRVKL LDSTVELFDI EPKCDGQVLL TQVWKHLNLI ECDYFGLEFK NVQSYWIWLE PMKPIIRQVR KPKNAVLRLA VKFFPPDPGQ LQEEYTRYLF ALQLKRDLLE ERLTCTANTA ALLISHLLQS EIGDYDETLD REHLKANEYL PNQEKSLEKI LDFHQRHTGQ TPAESDFQVL EIARKLEMYG IRFHMASDRE GTKINLAVSH MGVLVFQGTT KINTFNWSKV RKLSFKRKRF LIKLHPEVHG PYQDTLEFLL GSRDECKNFW KICVEYHTFF RLSDQPKPKA KAVFFSRGSS FRYSGRTQKQ LVDYVKDGGM KRIPYERRHS KTRTSLHALT VDLPKQSVSF TDGLRTSASL SSANVSFYPP PSSSLSPPGL PNLKDSSSSL VDPQAPVIKS TAAERSSGPS SSDGPSTQSA HLPGPPVLRP GPGFSMDSPQ PSPSSLKSHL SLCPELQAAL STAEQGASPV LSPVLSGAGT ARMDNQEEQK HKHMPEDEAY FIAKEILATE RTYLKDLEVI TVWFRSVLIK EEAMPAALMA LLFSNIDPVY EFHRGFLHEV EQRLALWEGP SSAHLKGDHQ RIGDILLRNM RQLKEFTSYF QRHDEVLTEL EKATKHCKKL EAVYKEFELQ KVCYLPLNTF LLKPVQRLVH YRLLLSRLCA HYSPGHRDYA DCHEALKAIT EVTTELQQSL TRLENLQKLT ELQRDLVGVE NLIAPGREFI REGCLHKLTK KGLQQRMFFL FSDMLLYTSK SVTGASHFRI RGFLPLRGML VEESENEWSV PHCFTIYAAQ KTIVVAASTR LEKEKWMQDL NAAIQAAKTI GDSPPVLLGG PVYTRTPRSS DEVSLEESED GRGNRGSLEG NSQHRANTTM HVCWYRNTSV SRADHSAAVE NQLSGYLLRK FKNSNGWQKL WVVFTNFCLF FYKTHQDDYP LASLPLLGYS VSLPREADSI HKDYVFKLQF KSHVYFFRAE SKYTFERWMD VIKRASSSPG RPPSFTQDCS HHSPGLEAEI REKEACPSPC LDKNL Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: FARP2 (FERM, RhoGEF and Pleckstrin Domain Protein 2 (FARP2))

Alternative Name: Farp2 (FARP2 Products)

Background: FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2),FUNCTION: Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity (PubMed:23375260, PubMed:20702777). Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion. {ECO:0000269|PubMed:12351724, ECO:0000269|PubMed:16286926, ECO:0000269|PubMed:20702777, ECO:0000269|PubMed:23375260}.

Molecular Weight: 121.3 kDa

UniProt: Q91VS8

AlphaFold: Q91VS8