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Human CD31 Protein expressed in HEK-293 Cells - ABIN2181646
Guzzo, Ichikawa, Park, Phillips, Liu, Zhang, Kwon, Miao, Lu, Rehm, Arthos, Cicala, Cohen, Fauci, Kehrl, Lusso: Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing. in Science immunology 2017
novel pathway for PECAM-1 regulation
PECAM-1 may not function as a major mechanoreceptor for activation of MAPK (show MAPK1 Proteins) and AKT (show AKT1 Proteins) in ECs and that there are likely to be other mechanoreceptors in ECs functioning to detect shear stress and trigger intercellular signals.
PECAM-1 and Fyn (show FYN Proteins) are essential components of a PECAM-1-based mechanosensory complex in endothelial cells
PECAM-1 plays a role in the early pathogenesis of thrombotic meningoencephalitis.
Sirt1 (show SIRT1 Proteins) expression is associated with CD31 (show HBA1 Proteins) expression in endothelial progenitor cells from patients with chronic obstructive pulmonary disease.
we found a significant cumulative contribution of the genetic heterogeneity of glycoproteins Ia and IIIa and platelet-endothelial cell adhesion molecule-1 and P-Selectin (show SELP Proteins) genes in the risk of recurrent IVF (show SCN5A Proteins)-ET failures. The coexistence of these SNPs was associated with increased IVF (show SCN5A Proteins)-ET failure risk and the more polymorphic alleles or genotypes were present the higher the risk of IVF (show SCN5A Proteins)-ET failure, especially for younger women
Dimer conformation of soluble PECAM-1
RrgA, binds both polymeric immunoglobulin receptor (pIgR (show PIGR Proteins)) and PECAM-1, whereas the choline binding protein PspC binds, but to a lower extent, only pIgR (show PIGR Proteins)
this study shows a significant role for CD31 (show HBA1 Proteins) during T cell development
Cells in high glucose for 7 days showed a significant decrease in mRNA expression of CD31 (show HBA1 Proteins) and VE-cadherin (show CDH5 Proteins), and a significant increase in that of alpha-SMA (show SMN1 Proteins) and collagen I.
Patients who had optic neuritis that progressed to multiple sclerosis had a decrease in serum PECAM-1 levels.
Platelet endothelial cell adhesion molecule (PECAM-1) is expressed in endothelial cells (ECs), platelets, and leukocytes, regulating the interaction between those cells.
Data indicate no association of maternal or fetal ITGA2 (show ITGA2 Proteins) C807T SNP, ITGB3 (show ITGB3 Proteins) T1565C SNP, PECAM1 CTG - GTG (show GGT1 Proteins) and SELP (show SEPP1 Proteins) A/C polymorphisms with fetal growth restriction (FGR (show FGR Proteins)).
these data suggest that a sialic acid-containing glycan emanating from Asn-25 reinforces dynamic endothelial cell-cell interactions by stabilizing the PECAM-1 homophilic binding interface.
findings suggest that PECAM-1 enhances SDF-1 (show CXCL12 Proteins)-induced chemotaxis by augmenting and prolonging activation of the PI3K/Akt (show AKT1 Proteins)/mTORC1 pathway and Rap1 (show TERF2IP Proteins) and that PECAM-1, at least partly, exerts its activity by inhibiting SDF-1 (show CXCL12 Proteins)-induced internalization of CXCR4 (show CXCR4 Proteins)
The data in this study provide evidence for the differential involvement of PECAM-1-ligand interactions in PECAM-1-dependent motility and the extension of filopodia.
Both the number of lung CD31-CD45 (show PTPRC Proteins)-Sca-1+ cells and the expression levels of the Shh (show SHH Proteins) signaling pathway were downregulated in the lung tissues of mice with pulmonary emphysema. These cells and Shh (show SHH Proteins) signaling pathway are reactivated during acute adenovirus infection.
In FVB/n mice, PECAM functions upstream of CD99 (show CD99 Proteins) in leukocyte diapedesis and blocking antibodies against either molecule arrest neutrophils before they traverse the endothelium. However, in C57BL/6 mice, PECAM and CD99 (show CD99 Proteins) appear to function at a different step, as the same antibodies arrest leukocyte migration through the endothelial basement membrane.
These studies indicate a role for PECAM-1 in enhancing the inhibitory functions of TGF-beta (show TGFB1 Proteins) in T cells
PECAM1 acts upstream of Gab1, promoting Gab1/Akt (show AKT1 Proteins)/eNOS (show NOS3 Proteins) phosphorylation and activation, thereby confers EC responsiveness to flow.
Radiation-induced stress conditions induce a transient accumulation of granulocytes within the liver by down-regulation/absence of PECAM-1.
CD31 gene transfer is sufficient to recapitulate the cytoprotective mechanisms in CD31(-) pancreatic beta cells, which become resistant to immune-mediated rejection when grafted in fully allogeneic recipients
PECAM1+ melanoma cells form vascular channels
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation.
platelet endothelial cell adhesion molecule
, CD31 antigen
, platelet/endothelial cell adhesion molecule (CD31 antigen)
, type I transmembrane endothelial adhesion molecule