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Human CD31 Protein expressed in HEK-293 Cells - ABIN2181646
Guzzo, Ichikawa, Park, Phillips, Liu, Zhang, Kwon, Miao, Lu, Rehm, Arthos, Cicala, Cohen, Fauci, Kehrl, Lusso: Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing. in Science immunology 2017
Human CD31 Protein expressed in HEK-293T Cells - ABIN1684606
Kitazume, Imamaki, Kurimoto, Ogawa, Kato, Yamaguchi, Tanaka, Ishida, Ando, Kiso, Hashii, Kawasaki, Taniguchi: Interaction of platelet endothelial cell adhesion molecule (PECAM) with α2,6-sialylated glycan regulates its cell surface residency and anti-apoptotic role. in The Journal of biological chemistry 2014
novel pathway for PECAM-1 regulation
PECAM-1 may not function as a major mechanoreceptor for activation of MAPK (show MAPK1 Proteins) and AKT (show AKT1 Proteins) in ECs and that there are likely to be other mechanoreceptors in ECs functioning to detect shear stress and trigger intercellular signals.
PECAM-1 and Fyn (show FYN Proteins) are essential components of a PECAM-1-based mechanosensory complex in endothelial cells
PECAM-1 plays a role in the early pathogenesis of thrombotic meningoencephalitis.
TNF-alpha (show TNF Proteins) and IL-10 (show IL10 Proteins) treatment can affect the expression of ICAM-1 (show ICAM1 Proteins) and CD31 (show HBA1 Proteins) in human coronary artery endothelial cells.
High CD31 (show HBA1 Proteins) expression is associated with early-stage, but not in late-stage, laryngeal squamous cell carcinoma.
Adenocarcinomas showed significantly higher staining scores of both VEGF (show VEGFA Proteins) and alphaSMA (show ACTA2 Proteins) than squamous cell carcinomas did. In 42 cases of high CD31 (show HBA1 Proteins) score, five-year survival rate (87%) of patients with lung cancer showing mature tumor vessels was significantly better than that (69%) of patients with immature tumor vessels
Differences in trafficking of CD31 (show HBA1 Proteins)(+) cytotoxic T lymphocytes during acute influenza infection could modulate tolerance and contribute to a dampened adaptive immune response in neonates
Cell adhesion assays on wildtype and mutant PECAM-1 further characterized the structural determinants in cell junction and communication.
In primary hip OA, angiogenesis may be induced by a combined mechanism: hypoxia-related VEGF (show VEGFA Proteins)-dependent vasculogenesis and endothelial differentiation of the activated pluripotent cells, which are released from the hyperplastic synovial cells layer. An endothelial mesenchymal transition is assumed to be involved in the fibrotic process.
upregulation of sVEGFR-1 with concomitant decline of PECAM-1 and sVEGFR-2 levels in preeclampsia compared to normotensive pregnancies, Irrespective of the HIV status
Increased expression of PECAM-1, ICAM-3 (show ICAM3 Proteins), and VCAM-1 (show VCAM1 Proteins) in colonic biopsies from patients with inflammatory bowel disease (IBD) in clinical remission is associated with subsequent flares; this suggests that increases in the expression of these proteins may be early events that lead to flares in patients with IBD.
PECAM-1 gene polymorphisms are associated with Kawasaki disease with and without coronary artery lesions in Chinese children.
Our combined data indicate that as HPMECs achieve confluence and CD31 (show HBA1 Proteins) ectodomains become homophilically engaged, multiple SFKs are activated to increase tyrosine phosphorylation of p120ctn (show CTNND1 Proteins), which in turn, functions as a cross-bridging adaptor molecule that physically couples NEU1 (show NEU1 Proteins) to CD31 (show HBA1 Proteins), permitting NEU1 (show NEU1 Proteins)-mediated desialylation of CD31 (show HBA1 Proteins).
Study confirmes that the presence of functional PECAM1 on the endothelium promotes a proliferative tumor cell phenotype in vivo and in vitro. These proproliferative effects were mediated by soluble endothelialderived factors that are dependent on PECAM1 homophilic ligand interactions, but are independent of PECAM1dependent signaling.
PECAM is required for fibronectin (show FN1 Proteins) assembly in vascular endothelium during flow-mediated vascular remodeling.
Differences in trafficking of CD31(+) cytotoxic T lymphocytes during acute influenza infection could modulate tolerance and contribute to a dampened adaptive immune response in neonates
Stromal DNA replication was highly activated in the uterus of CD31(-/-) mice, manifested by upregulated cyclin series signaling and PCNA expression after E2 + P4 treatment. Collectively, CD31 inhibits E2 -mediated epithelial proliferation via recruitment and phosphorylation of SHP-2 upon receiving P4 signal in early pregnancy.
findings suggest that PECAM-1 enhances SDF-1 (show CXCL12 Proteins)-induced chemotaxis by augmenting and prolonging activation of the PI3K/Akt (show AKT1 Proteins)/mTORC1 pathway and Rap1 (show TERF2IP Proteins) and that PECAM-1, at least partly, exerts its activity by inhibiting SDF-1 (show CXCL12 Proteins)-induced internalization of CXCR4 (show CXCR4 Proteins)
The data in this study provide evidence for the differential involvement of PECAM-1-ligand interactions in PECAM-1-dependent motility and the extension of filopodia.
RrgA, binds both polymeric immunoglobulin receptor (pIgR (show PIGR Proteins)) and PECAM-1, whereas the choline binding protein PspC binds, but to a lower extent, only pIgR (show PIGR Proteins)
Both the number of lung CD31-CD45 (show PTPRC Proteins)-Sca-1+ cells and the expression levels of the Shh (show SHH Proteins) signaling pathway were downregulated in the lung tissues of mice with pulmonary emphysema. These cells and Shh (show SHH Proteins) signaling pathway are reactivated during acute adenovirus infection.
In FVB/n mice, PECAM functions upstream of CD99 (show CD99 Proteins) in leukocyte diapedesis and blocking antibodies against either molecule arrest neutrophils before they traverse the endothelium. However, in C57BL/6 mice, PECAM and CD99 (show CD99 Proteins) appear to function at a different step, as the same antibodies arrest leukocyte migration through the endothelial basement membrane.
These studies indicate a role for PECAM-1 in enhancing the inhibitory functions of TGF-beta (show TGFB1 Proteins) in T cells
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation.
platelet endothelial cell adhesion molecule
, CD31 antigen
, platelet/endothelial cell adhesion molecule (CD31 antigen)
, type I transmembrane endothelial adhesion molecule