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anti-Human LPAR3 Antibodies:
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Human Polyclonal LPAR3 Primary Antibody for IF (p), IHC (p) - ABIN681133
Chen, Zhang, Deng, Liu, Yang, Wu, Yu: Lysophosphatidic acid directly induces macrophage-derived foam cell formation by blocking the expression of SRBI. in Biochemical and biophysical research communications 2017
EDG4 and EDG7 map to q2.1 of pig chromosome 2 (SSC2) and q2.6-3.2 of pig chromosome6 (SSC6), respectively
EDG7 was regulated by pregnancy stage and status. EDG7 expression was highest on d 12 pregnancy, and localized to the luminal and glandular epithelium, and EDG7 mRNA levels were elevated by estrogen in the endometrium.
Using pharmacological activators and shRNA knockdown experiments, we demonstrate that activation of LPA3 inhibits megakaryopoiesis in human HSCs. In addition, pharmacological activation of LPA3 suppressed thrombopoiesis in zebrafish.
The results indicate that LPA2 and LPA3 receptors play opposing roles during red blood cells differentiation.
myeloma cells stimulate mesenchymal stem cells (MSCs to produce autotaxin, an indispensable enzyme for the biosynthesis of lysophosphatidic acid, and LPA receptor 1 (LPA1) and 3 (LPA3) transduce opposite signals to MSCs to determine the fate of MSCs.
Expression profiles reveal LPAR3 (lysophosphatidic acid receptor 3) as a mediator for mitotic phosphorylation-driven pancreatic cell motility and invasion. Together, this work identifies YAP as a novel regulator of pancreatic cancer cell motility, invasion and metastasis.
These data indicated that the expression of LPA receptor 3 was increased in human triple-negative breast cancers and is associated with tumor metastatic ability.
Suggest that LPA2 and LPA3 may function as a molecular switch and play opposing roles during megakaryopoiesis of K562 cells.
The results demonstrate LPA-stimulated migration in oral carcinoma cells through LPAR3, mediated further by PKC, which acts either in concert with or independently of EGFR transactivation
Findings indicate lysophosphatidic acid (LPA)-lysophosphatidic acid receptor-Galpha13 signaling node as a therapeutic target for pancreatic cancer treatment and control.
LPA3 mRNA is clearly expressed in human PANC-1 tumor cells.
Lysophosphatidic acid (LPA) increased hepatocellular carcinoma cells cell invasion, which was LPA-receptor dependent.
in the normal human menstrual cycle, lysophosphatidic acid receptor 3 messenger RNA and protein expression change, indicating that this gene may be related to the function of the endometrium.
The results indicated that LPA(3) acts as a positive regulator of cell motility and invasion in sarcoma cells, suggesting that LPA signaling pathway via LPA(3) may be involved in the progression of sarcoma cells.
High LPAR3 expression is associated with aggressiveness of breast carcinoma.
LPA3 Receptor act as a negative regulator on cell motile and invasive abilities of colon cancer.
found that LPA receptor 2/3-mediated IL-8 expression occurs through Gi/PI3K/AKT, Gi/PKC and IkappaB/NF-kappaB signaling
study found that LPS induces both ATX and LPA3 expression in THP-1 cells; the PKR and SPK1-mediated pathways are involved in both ATX and LPA3 induction, resulting in the coordinate up-regulation of these two genes
Mutation in LPA3 gene indicate that the alterations in LPA receptor gene may play some role in pathogenesis in human osteosarcoma cells.
Data show that CLL cells express LPA receptors LPA(1-5) and VEGF receptors, and the plasma levels of VEGF are elevated in CLL patients.
show that human microglia express LPA receptor subtypes LPA(1), LPA(2), and LPA(3) on mRNA and protein level. LPA activation of C13NJ cells induced Rho and extracellular signal-regulated kinase activation and enhanced cellular ATP production.
demonstrate that two biological fluids, blood plasma and seminal plasma, differentially activate LPA receptors
we demonstrate that LPA1/3 antagonism mildly reduced plasma LDL cholesterol levels. Therefore, pharmacological inhibition of LPA1/3 receptors may prove a promising approach to diminish atherosclerosis development.
These results indicate that ATX-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF and COX-2 pathways.
Lpar3(-/-) female mice had delayed embryo implantation.
These results suggest that LPA3 receptor-mediated amplification of spinal LPA production is required for the development of paclitaxel-induced neuropathic pain.
These results suggest that LPA signaling through LPA3 may inhibit angiogenesis and fibroblast activation in mouse lung cancer cells
The thromboxane A(2) receptor agonist 11-deoxy PGF(2alpha) can partially alleviate embryo crowding in the Lpar3((-/-)) females and embryo crowding likely contributes to reduced litter size in the Lpar3((-/-)) females.
Lysophosphatidic acid, via LPA(1) and LPA(3) receptors, may play a significant role in inducing and/or sustaining the massive infiltration of leukocytes during inflammation
Luminal epithelium localization and up-regulation by progesterone differentiate LPA3 from the other nine LP receptors and may underlie its essential role in embryo implantation.
LPA(1-3) are differentially expressed in the central nervous system and their expression is upregulated in response to injury.
Lysophosphatidic acid receptors LPA3 and LPA1 promote CXCL12-mediated smooth muscle progenitor cell recruitment.
LPA3 receptor-mediated signalling has an influence on embryo implantation, and there is a linkage between LPA signalling and prostaglandin biosynthesis.
Progesterone and estrogen cooperatively regulate LPA(3) expression, thereby contributing to the receptivity of uteri during early pregnancy.
A novel in vivo function for LPA signaling as a germ cell survival factor during spermatogenesis.
This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7
, lysophosphatidic acid receptor 3
, LPA receptor 3
, LPA receptor EDG7
, calcium-mobilizing lysophosphatidic acid receptor LP-A3
, endothelial cell differentiation gene 7
, lysophosphatidic acid receptor Edg-7
, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7
, putative G protein-coupled receptor snGPCR32