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EDG4 and EDG7 map to q2.1 of pig chromosome 2 (SSC2) and q2.6-3.2 of pig chromosome6 (SSC6), respectively
EDG7 was regulated by pregnancy stage and status. EDG7 expression was highest on d 12 pregnancy, and localized to the luminal and glandular epithelium, and EDG7 mRNA levels were elevated by estrogen in the endometrium.
Expression profiles reveal LPAR3 (lysophosphatidic acid receptor 3) as a mediator for mitotic phosphorylation-driven pancreatic cell motility and invasion. Together, this work identifies YAP (show YAP1 ELISA Kits) as a novel regulator of pancreatic cancer cell motility, invasion and metastasis.
These data indicated that the expression of LPA receptor 3 was increased in human triple-negative breast cancers and is associated with tumor metastatic ability.
Suggest that LPA2 (show LPAR2 ELISA Kits) and LPA3 may function as a molecular switch and play opposing roles during megakaryopoiesis of K562 cells.
The results demonstrate LPA (show APOA ELISA Kits)-stimulated migration in oral carcinoma cells through LPAR3, mediated further by PKC, which acts either in concert with or independently of EGFR (show EGFR ELISA Kits) transactivation
Findings indicate lysophosphatidic acid (LPA)-lysophosphatidic acid receptor-Galpha13 signaling node as a therapeutic target for pancreatic cancer treatment and control.
LPA3 mRNA is clearly expressed in human PANC-1 tumor cells.
Lysophosphatidic acid (LPA) increased hepatocellular carcinoma cells cell invasion, which was LPA-receptor dependent.
in the normal human menstrual cycle, lysophosphatidic acid receptor 3 messenger RNA and protein expression change, indicating that this gene may be related to the function of the endometrium.
The results indicated that LPA(3) acts as a positive regulator of cell motility and invasion in sarcoma cells, suggesting that LPA (show APOA ELISA Kits) signaling pathway via LPA(3) may be involved in the progression of sarcoma cells.
High LPAR3 expression is associated with aggressiveness of breast carcinoma.
These results indicate that ATX (show ENPP2 ELISA Kits)-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF (show HBEGF ELISA Kits) and COX-2 (show COX2 ELISA Kits) pathways.
Lpar3(-/-) female mice had delayed embryo implantation.
These results suggest that LPA3 receptor-mediated amplification of spinal LPA production is required for the development of paclitaxel-induced neuropathic pain.
These results suggest that LPA signaling through LPA3 may inhibit angiogenesis and fibroblast activation in mouse lung cancer cells
The thromboxane A(2) receptor agonist 11-deoxy PGF (show PTGFR ELISA Kits)(2alpha) can partially alleviate embryo crowding in the Lpar3((-/-)) females and embryo crowding likely contributes to reduced litter size in the Lpar3((-/-)) females.
Lysophosphatidic acid, via LPA(1 (show LPAR1 ELISA Kits)) and LPA(3) receptors, may play a significant role in inducing and/or sustaining the massive infiltration of leukocytes during inflammation
Luminal epithelium localization and up-regulation by progesterone differentiate LPA3 from the other nine LP receptors and may underlie its essential role in embryo implantation.
LPA(1 (show LPAR1 ELISA Kits)-3) are differentially expressed in the central nervous system and their expression is upregulated in response to injury.
Lysophosphatidic acid receptors LPA3 and LPA1 (show LPAR1 ELISA Kits) promote CXCL12 (show CXCL12 ELISA Kits)-mediated smooth muscle progenitor cell recruitment.
LPA3 receptor-mediated signalling has an influence on embryo implantation, and there is a linkage between LPA signalling and prostaglandin biosynthesis.
This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7
, lysophosphatidic acid receptor 3
, LPA receptor 3
, LPA receptor EDG7
, calcium-mobilizing lysophosphatidic acid receptor LP-A3
, endothelial cell differentiation gene 7
, lysophosphatidic acid receptor Edg-7
, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7
, putative G protein-coupled receptor snGPCR32