Browse our anti-Neuropilin 1 (NRP1) Antibodies

Human Neuropilin 1 (NRP1) interaction partners

1. NRP-1 forms a complex with GIPC1 and Syx to activate RhoA/ROCK-dependent p38 activity to enhance the Epidermal cancer stem cell phenotype and tumor formation.

2. the effects of NRP1 knockdown in cancer cells are dependent on the genetic status of KRAS.

3. The hypomethylated gene, NRP1, and its co-expressed gene, PDGFRB, were significantly correlated with tumor malignant phenotypes.

4. Authors demonstrate the presence of homo-interactions between NRP1 molecules, as well as hetero-interactions between NRP1 and VEGFR2 molecules, in the plasma membrane. Our results underscore the complex nature of the interactions between self-associating receptors, co-receptors, and their ligands in the plasma membrane.

5. NRP1 was confirmed be the downstream target of miR-9, and inversely modulated by miR-9 in ALL. NRP1 upregulation reversed the anti-cancer regulations of miR-9 on ALL in vitro proliferation and cell-cycle progression.

6. The article highlights the diverse NRP1 and NRP2 ligands and interacting partners on endothelial cells, which are relevant in the context of the tumor vasculature and the tumor microenvironment. (Review)

7. NRP1 can form complexes with FYN and have the correlation changes in odontoblast differentiation of dental pulp stem cells (DPSCs). Therefore, the study surmise that in the progress of dental caries, NRP1 interacts with FYN, by expanding inflammation and inhibition of odontoblast differentiation of DPSCs through nuclear factor kappa B signaling pathway.

8. High NRP1 expression promotes esophageal squamous cancer progression.

9. These findings support that diminished levels of NRP1 contribute to the development of TOF, likely through its function in mediating VEGF signal and vasculogenesis.

10. VEGF-A interacts with NRP-1 and GIPC1 to regulate alpha6/beta4-integrin, FAK, Src, PI3K/PDK1, LATS1 signaling to increase YAP1/Np63alpha accumulation.

11. The bevacizumab-independent VEGF/NRP1/ARHGAP17/Cdc42 regulatory network plays important roles in malignant behavior of breast cancer.

12. Study reports a novel mechanism correlating high baseline NRP-1 with upregulated TNC/ITGB3 signaling, but decreased ABCG2 expression, which sensitizes breast cancer cells to adriamycin/cyclophosphamide.

13. This work supports the importance of NRP-1-associated molecules in circulation to characterize poor prognosis breast cancer and emphasizes on their role as favorable drug targets.

14. we discovered that miR-124-3p acts as the upstream suppressor of NRP-1 which promotes GBM cell development and growth by PI3K/Akt/NFkappaB pathway.

15. HLA-G, NRP1, and PD-1, may be involved in the immune response in psoriatic patients

16. miR-320/NRP-1 axis contributes to the growth and metastasis of cholangiocarcinoma cells.

17. we demonstrated that HS3ST3B enhances the proliferation and survival of breast cancer MDA-MB-231 cells, via a mechanism that is dependent on Nrp1.

18. The serum NRP1 was significantly associated with AFP, gamma-GT, Alb, bile acid, ALT, AST, ALP and pre-Alb. NRP1 is a novel tumor marker in HCC.

19. lnc00152 was aberrantly overexpressed in colorectal tumors and cancer cells and that lnc00152 was modulated by miRNA206. lnc00152 overexpression promoted epithelial-mesenchymal transition and increased neuropilin1 expression in the colorectal cancer cells.

20. the results presented herein indicate that NRP1 exerts tumor suppressive effects in NB, at least in part by regulating the expression of beta1 integrin

Mouse (Murine) Neuropilin 1 (NRP1) interaction partners

1. Cooperation between NRP1 and PDGF signaling is required for secondary septation, and manipulation of NRP1 could promote alveolar regeneration without producing fibrosis.

2. In summary, the authors concluded that glycosylation-dependent Gal-1/NRP-1 interactions activate TGF-beta and PDGF-like signaling to promote the migration and activation of hepatic stellate cells.

3. Deletion of Nrp1 results in delay of mammary development. Knockdown of Nrp1 inhibits MMTV-Wnt1 tumor growth in xenograft.

4. We show that PTP-3, a LAR homolog in Caenorhabditis elegans, participates in Sema2A-regulated axon guidance. PTPdelta, a member of vertebrate LAR class PTPs, is involved in Sema3A-regulated cortical dendritic growth. In Sema3A signaling, PTPdelta activates Fyn and Src kinases by dephosphorylating their C-terminal Tyr residues.

5. High NRP1 expression promotes esophageal squamous cancer progression.

6. Findings of indicate that neuropilin-1 (Nrp1) vascular progenitor cells (VPCs) in the act as an important step in the arterial differentiation process.

7. Study shows that NPR2 is rather evenly distributed across mouse ventricular myocytes membrane and produces far-reaching, diffusible cGMP signals, whereas NPR1 is exclusively found in T-tubules where it creates a microdomain with restricted cGMP diffusion locally confined by PDE2.

8. High Neuropilin 1 expression is associated with Glioma Progression.

9. Our findings suggest a pivotal role for adipose tissue-resident NRP1(+)-expressing macrophages in driving healthy weight gain and maintaining glucose tolerance.

10. ErbB2 interacts with Nrp1 to form a Sema3d co-receptor expressed by developing coronary endothelium and required for proper connections of the forming coronary veins to the right atrium.

11. inducible endothelial genetic deletion of Neuropilin1 (Nrp1) and Vascular endothelial growth factor receptor 1 (Vegfr1; also known as Flt1) renders mice resistant to diet-induced obesity.

12. a novel role for Sema3A-neuropilin 1 signalling in progenitor cell dynamics and in the generation of interneurons in the ventral telencephalon

13. Tuftsin prevents the negative immunoregulation of neuropilin-1highCD4+CD25+Regulatory T cells and improves survival rate in septic mice.

14. the induction of NRP-1 on macrophages may be a therapeutic indicator for antibody treatments that exert antibody-dependent cellular cytotoxicity activity.

15. Nrp1 mediates the migratory behavior of mesangial cells.

16. These data suggest that both Nrp1 and Sema3a are expressed in the cochlea during time points when spiral ganglion cell begin to innervate the organ of Corti.

17. Reveal a postdevelopmental role of Nrp1 in renal pericytes as an important regulator of glomerular basement membrane integrity.

18. Conditional Nrp1 knockout study does not support the Nrp1 model - that olfactory-derived cAMP signals, rather than direct action of olfactory receptor molecules, determine the target destinations (glomeruli) of olfactory sensory neurons in the olfactory bulb - for the anterior-posterior patterning of glomerular positions in the olfactory bulb.

19. It was concluded that the HFD-instigated Nrp1 reduction in macrophages exacerbates insulin resistance by promoting Nlrp3 inflammasome priming and activation.

20. findings identify a dual function of NRP1 in both axon guidance and subcellular target recognition in the construction of GABAergic circuitry.

Xenopus laevis Neuropilin 1 (NRP1) interaction partners

1. Hermes negatively controls the translation of the guidance cue receptor Neuropilin-1 in retinal ganglion cells

2. Neuropilin-1 and its co-receptor plexinA1 are necessary to bias the extension of the dendrites of retinal ganglion cells to the apical side of the cell, and ectopically expressed class III semaphorins (Sema3s) disrupt this process.

Pig (Porcine) Neuropilin 1 (NRP1) interaction partners

1. binding of Neuropilin-1 to VEGFR-2 requires the PDZ-binding domain of neuropilin-1

2. Neuropilin-1 is essential for enhanced VEGF(165)-mediated vasodilatation in collateral-dependent coronary arterioles of exercise-trained pigs.