Browse our anti-Neuropilin 1 (NRP1) Antibodies

Human Neuropilin 1 (NRP1) interaction partners

1. NRP1 levels dictated the efficacy of MET oncogene inhibitors in addicted carcinoma cells. Mechanistically, NRP1 induced a JNK-dependent signaling cascade leading to the upregulation of alternative effector kinases.

2. PUM2 could facilitate the stemness of breast cancer cells by competitively binding to NRP-1 3'UTR with miR-376a.

3. NRP-1 expression was found exclusively in cancer cells from the endometrium of endometrial cancer patients.

4. Further metabolic pathway analysis revealed that disturbed lipid transportation and phospholipid metabolism probably contributed to the enhanced anti-hepatoma effect by NRP-1 knockdown in combination with SSd. Taken together, in this study, we provided possible interaction mechanisms between SSd and its predicted target NRP-1

5. High NRP1 expression is associated with cervical cancer.

6. NRP-1 forms a complex with GIPC1 and Syx to activate RhoA/ROCK-dependent p38 activity to enhance the Epidermal cancer stem cell phenotype and tumor formation.

7. the effects of NRP1 knockdown in cancer cells are dependent on the genetic status of KRAS.

8. The hypomethylated gene, NRP1, and its co-expressed gene, PDGFRB, were significantly correlated with tumor malignant phenotypes.

9. Authors demonstrate the presence of homo-interactions between NRP1 molecules, as well as hetero-interactions between NRP1 and VEGFR2 molecules, in the plasma membrane. Our results underscore the complex nature of the interactions between self-associating receptors, co-receptors, and their ligands in the plasma membrane.

10. NRP1 was confirmed be the downstream target of miR-9, and inversely modulated by miR-9 in ALL. NRP1 upregulation reversed the anti-cancer regulations of miR-9 on ALL in vitro proliferation and cell-cycle progression.

11. The article highlights the diverse NRP1 and NRP2 ligands and interacting partners on endothelial cells, which are relevant in the context of the tumor vasculature and the tumor microenvironment. (Review)

12. NRP1 can form complexes with FYN and have the correlation changes in odontoblast differentiation of dental pulp stem cells (DPSCs). Therefore, the study surmise that in the progress of dental caries, NRP1 interacts with FYN, by expanding inflammation and inhibition of odontoblast differentiation of DPSCs through nuclear factor kappa B signaling pathway.

13. High NRP1 expression promotes esophageal squamous cancer progression.

14. These findings support that diminished levels of NRP1 contribute to the development of TOF, likely through its function in mediating VEGF signal and vasculogenesis.

15. VEGF-A interacts with NRP-1 and GIPC1 to regulate alpha6/beta4-integrin, FAK, Src, PI3K/PDK1, LATS1 signaling to increase YAP1/Np63alpha accumulation.

16. The bevacizumab-independent VEGF/NRP1/ARHGAP17/Cdc42 regulatory network plays important roles in malignant behavior of breast cancer.

17. Study reports a novel mechanism correlating high baseline NRP-1 with upregulated TNC/ITGB3 signaling, but decreased ABCG2 expression, which sensitizes breast cancer cells to adriamycin/cyclophosphamide.

18. This work supports the importance of NRP-1-associated molecules in circulation to characterize poor prognosis breast cancer and emphasizes on their role as favorable drug targets.

19. we discovered that miR-124-3p acts as the upstream suppressor of NRP-1 which promotes GBM cell development and growth by PI3K/Akt/NFkappaB pathway.

20. HLA-G, NRP1, and PD-1, may be involved in the immune response in psoriatic patients

Mouse (Murine) Neuropilin 1 (NRP1) interaction partners

1. Post-crossing CCAs switch off their response to axon guidance cues, among which the secreted Semaphorin-3C (Sema3C), that act as attractants for pre-crossing axons on their way to the midline. This change is concomitant with an upregulation of the surface protein Ephrin-B1, which acts in CCAs to inhibit Sema3C signaling via interaction with the Neuropilin-1 (Nrp1) receptor.

2. Nrp1 signaling mediated accumulation of Tregs within tumor might play a critical role in exacerbating ischemic brain injury in cancer-bearing mice.

3. Cooperation between NRP1 and PDGF signaling is required for secondary septation, and manipulation of NRP1 could promote alveolar regeneration without producing fibrosis.

4. In summary, the authors concluded that glycosylation-dependent Gal-1/NRP-1 interactions activate TGF-beta and PDGF-like signaling to promote the migration and activation of hepatic stellate cells.

5. Deletion of Nrp1 results in delay of mammary development. Knockdown of Nrp1 inhibits MMTV-Wnt1 tumor growth in xenograft.

6. We show that PTP-3, a LAR homolog in Caenorhabditis elegans, participates in Sema2A-regulated axon guidance. PTPdelta, a member of vertebrate LAR class PTPs, is involved in Sema3A-regulated cortical dendritic growth. In Sema3A signaling, PTPdelta activates Fyn and Src kinases by dephosphorylating their C-terminal Tyr residues.

7. High NRP1 expression promotes esophageal squamous cancer progression.

8. Findings of indicate that neuropilin-1 (Nrp1) vascular progenitor cells (VPCs) in the act as an important step in the arterial differentiation process.

9. Study shows that NPR2 is rather evenly distributed across mouse ventricular myocytes membrane and produces far-reaching, diffusible cGMP signals, whereas NPR1 is exclusively found in T-tubules where it creates a microdomain with restricted cGMP diffusion locally confined by PDE2.

10. High Neuropilin 1 expression is associated with Glioma Progression.

11. Our findings suggest a pivotal role for adipose tissue-resident NRP1(+)-expressing macrophages in driving healthy weight gain and maintaining glucose tolerance.

12. ErbB2 interacts with Nrp1 to form a Sema3d co-receptor expressed by developing coronary endothelium and required for proper connections of the forming coronary veins to the right atrium.

13. inducible endothelial genetic deletion of Neuropilin1 (Nrp1) and Vascular endothelial growth factor receptor 1 (Vegfr1; also known as Flt1) renders mice resistant to diet-induced obesity.

14. a novel role for Sema3A-neuropilin 1 signalling in progenitor cell dynamics and in the generation of interneurons in the ventral telencephalon

15. Tuftsin prevents the negative immunoregulation of neuropilin-1highCD4+CD25+Regulatory T cells and improves survival rate in septic mice.

16. the induction of NRP-1 on macrophages may be a therapeutic indicator for antibody treatments that exert antibody-dependent cellular cytotoxicity activity.

17. Nrp1 mediates the migratory behavior of mesangial cells.

18. These data suggest that both Nrp1 and Sema3a are expressed in the cochlea during time points when spiral ganglion cell begin to innervate the organ of Corti.

19. Reveal a postdevelopmental role of Nrp1 in renal pericytes as an important regulator of glomerular basement membrane integrity.

20. Conditional Nrp1 knockout study does not support the Nrp1 model - that olfactory-derived cAMP signals, rather than direct action of olfactory receptor molecules, determine the target destinations (glomeruli) of olfactory sensory neurons in the olfactory bulb - for the anterior-posterior patterning of glomerular positions in the olfactory bulb.

Xenopus laevis Neuropilin 1 (NRP1) interaction partners

1. Hermes negatively controls the translation of the guidance cue receptor Neuropilin-1 in retinal ganglion cells

2. Neuropilin-1 and its co-receptor plexinA1 are necessary to bias the extension of the dendrites of retinal ganglion cells to the apical side of the cell, and ectopically expressed class III semaphorins (Sema3s) disrupt this process.

Pig (Porcine) Neuropilin 1 (NRP1) interaction partners

1. binding of Neuropilin-1 to VEGFR-2 requires the PDZ-binding domain of neuropilin-1

2. Neuropilin-1 is essential for enhanced VEGF(165)-mediated vasodilatation in collateral-dependent coronary arterioles of exercise-trained pigs.