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anti-Mouse (Murine) Antibodies:
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Rat (Rattus) Monoclonal TNR Primary Antibody for ICC, IHC - ABIN1742431
Weber, Bartsch, Rasband, Czaniera, Lang, Bluethmann, Margolis, Levinson, Shrager, Montag, Schachner: Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
Show all 4 Pubmed References
Two genes, TNR (and TNK2 (show TNK2 Antibodies)), were found to have genetic variations linked to familial Parkinson's Disease.
TnC (show TNC Antibodies) and TnR play important roles in nervous and immune systems. [Review]
citation presents comparison with human gene.
results show that tenascin-R expression is tightly regulated in a spatiotemporal manner during brain development, especially cortical plate formation; its pattern of expression suggests a role for tenascin-R in corticogenesis
KIAA0510, the 3'-untranslated region of the tenascin-R gene, and tenascin-R are overexpressed in pilocytic astrocytomas
The researchers found evidence that the tenascin R gene is a potential susceptiblity or marker gene for IgA (show IgA Antibodies) nephropathy.
Tenascin R is expressed and glycosylated in neurons
An extracellular matrix molecule TNR and its associated carbohydrate human natural killer cell glycan (HNK-1 (show B3GAT1 Antibodies)) provide conditions beneficial for induction of long-term potentiation in the hippocampus.
The synaptic plasticity occurs in the hippocampus of freely behaving mice that lack tenascin-C (show TNC Antibodies), the informational content stored by synaptic plasticity is not the same.
Tenascin-R promotes assembly of the extracellular matrix of perineuronal nets via clustering of aggrecan (show ACAN Antibodies).
Aggrecan (show ACAN Antibodies), link protein (show HAPLN1 Antibodies) and TN-R were identified to be essential for the neuroprotective properties of the perineuronal net.
These findings indicate the importance of TNR in the regulation of hippocampal neurogenesis and suggest that TNR acts through distinct direct and indirect mechanisms during development and in the adult.
TNR is expressed in a subset of astrocytes and contributes to glutamate (show GRIN1 Antibodies) homeostasis by regulating astrocytic GLAST (show SLC1A3 Antibodies) expression.
Our results indicate that TNR modulates adult but not developmental neurogenesis in the olfactory bulb
This study provided evidence that the tenascin-R modulates synaptogenesis and long-term synapse stability. The mutant neurons display reduced frequencies of mEPSCs and mIPSCs.
Ablation of TNR modifies the extracellular matrix and leads to reorganization of the dentate gyrus with enhanced GABAergic innervation and altered plasticity, promoting working memory and reversal learning.
TN-R appears to play an important role in the regulation of the number and architecture of perisomatic inhibitory synapses onto hippocampal pyramidal cells.
the impact of TN-R deficiency on the living animal
Tenascin-R (TNR) is an extracellular matix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion\; MIM 187380), TNX (TNXB\; MIM 600985), and TNR (Erickson, 1993
, neural recognition molecule J1-160/180
, Tenascin-R (Restrictin janusin J1-160/180)
, Tenascin-R (Restrictin, janusin, J1-160/180)
, tenascin R (restrictin, janusin)