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Tubulin-tyrosine ligase (TTL) is required to increase the levels of tyrosinated alpha-tubulin (show TUBA4A Proteins) at the axon injury site and plays an important role in injury signaling.
Our results show that MAP1B (show MAP1B Proteins) abd tubulin-tyrosine ligase indeed interact and that the interaction is not affected by MAP1B (show MAP1B Proteins) phosphorylation.
TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003
, tubulin-tyrosine ligase