Browse our WD Repeat Domain 36 Proteins (WDR36)

Mouse (Murine) WD Repeat Domain 36 (WDR36) interaction partners

1. Our data obtained in Wdr36(+/-) mice do not support the assumption of a causative role for WDR36 in the pathogenesis of primary open-angle glaucoma.

2. results provide evidence that WDR36 is an essential protein in mammalian cells which is involved in the nucleolar processing of small subunit 18S rRNA

3. WDR36 plays an important functional role in the retina homeostasis and mutation to this gene can cause devastating retinal damage.

Zebrafish WD Repeat Domain 36 (WDR36) interaction partners

1. Loss of Wdr36 function leads to an activation of the p53 (show TP53 Proteins) stress-response pathway, suggesting that defects in p53 (show TP53 Proteins) pathway may influence the impact of WDR36 variants on primary open-angle glaucoma.

Human WD Repeat Domain 36 (WDR36) interaction partners

1. Study suggests that WDR36 gene is involved in the pathogenesis of juvenile open-angle glaucoma in Taiwan population as a subordinate modifier gene.

2. Meta-analysis does not support a significant role of WDR36 in the genetic susceptibility of primary open angle glaucoma or its subtypes.

3. The association between WDR36 and POAG was not supported, and the majority of POAG cases did not harbor a potentially disease-causing variant in the remaining Mendelian genes.

4. Familial linkage studies for primary angle-closure glaucoma have been performed and identified WDR36 causative primary angle-closure glaucoma disease

5. According to molecular genetic studies, WDR36 causative gene involved in the development of Primary open-angle glaucoma.

6. Single nucleotide polymorphism in the WDR36 gene, rs10038177 (c.710+30C>T), was found to be strongly associated with the high tension glaucoma cases, but not with controls in the East Indian population.

7. Rare WDR36 variants and the P53 (show TP53 Proteins) p.R72P polymorphism behaved as moderate glaucoma risk factors in Spanish patients. The authors provide evidence for a genetic interaction between WDR36 and P53 (show TP53 Proteins) variants in glaucoma susceptibility.

8. WDR36 acts as a scaffold protein (show HOMER1 Proteins) tethering a G-protein-coupled receptor (show ADRA1A Proteins), Galphaq (show GNAQ Proteins) and phospholipase C beta 2 (show PLCb2 Proteins) in a signalling complex

9. WDR36 sequence variance was only a rare cause of primary open-angel glaucoma glaucoma in Italian families with glaucoma.

10. Genetic variants of CYP1B1 (show CYP1B1 Proteins) and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg