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anti-Mouse (Murine) ADRBK2 Antibodies:
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Human Polyclonal ADRBK2 Primary Antibody for EIA, IHC (p) - ABIN950649
Rao, Rapoport, Kim: Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients. in The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2009
Show all 2 Pubmed References
Human Polyclonal ADRBK2 Primary Antibody for WB - ABIN390986
Calabrese, Sallese, Stornaiuolo, Stuppia, Palka, De Blasi: Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes. in Genomics 1995
Show all 4 Pubmed References
GRK3 controls cardiac alpha1-adrenergic receptor responsiveness
GRK3 is a new critical activator of neuroendocrine phenotypes and mediator of CREB (show CREB1 Antibodies) activation in promoting neuroendocrine differentiation of prostate cancer cells.
effects of GRK3 modulation appear to be specific to chemokine (show CCL1 Antibodies)-mediated migration behaviors without influencing tumor cell proliferation or survival
data are consistent with the possibility that oncogenes can induce cellular stiffness via an HDAC6 (show HDAC6 Antibodies)-induced reorganization of the vimentin (show VIM Antibodies) intermediate filament network
Data indicate that CXCL12 (show CXCL12 Antibodies)-induced phosphorylation at CXCR4 (show CXCR4 Antibodies) S346/347 was mediated by GRK2/3.
In oral squamous cell carcinomas, malignant cells and surrounding tissue overexpress the ADRBK2 gene.
A reduced cortical concentration of GRK3 in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia.
GRK3 is a negative regulator of cell growth whose expression is preferentially reduced in glioblastoma of the classical subtype as a consequence of activity in primary gliomagenic pathways.
mRNA levels for GRK3 were inversely correlated with systolic and diastolic blood pressure (day, night and 24 h), which suggests a protective role for GRK3 in the regulation of human blood pressure
we found no evidence of altered levels of acetylated histone H3 (show HIST3H3 Antibodies) at the affected allele compared to the common allele
dysregulation in GRK3 expression alters signaling desensitization, and thereby predisposes to the development of bipolar disorder
beta-arrestin 2 (show ARRB2 Antibodies) and GRK2 (show ADRBK1 Antibodies) colocalize with S1p2 (show S1PR2 Antibodies) in developing zebrafish embryos and depletion of GRK2 (show ADRBK1 Antibodies) in the S1p2 (show S1PR2 Antibodies) R150H miles apart zebrafish partially rescued cardia bifida.
GRK2 (show ADRBK1 Antibodies) and GRK5 (show GRK5 Antibodies) control cardiac function as well as morphogenesis during development although with different morphological outcomes.
Data suggest that a G protein-coupled receptor (show GPBAR1 Antibodies) kinase, perhaps GRK2 (show ADRBK1 Antibodies) or 3, functions as a vertebrate kinase for Smoothened (show SMO Antibodies), promoting Hedgehog (show SHH Antibodies) signal transduction during early development.
These data thus reveal a novel kinase activity-independent function for GRK and establish a role for GRK2 as a cell-cycle regulator during early embryonic development.
Fusion proteins containing the c-terminus of GPCR kinase 3 (GRK3ct) and either the fluorescent protein cerulean or Renilla luciferase bind to venus-labeled Gbetagamma dimers, resulting in Forster or bioluminescence resonance energy transfer.
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
adrenergic, beta, receptor kinase 2
, beta-adrenergic receptor kinase 2-like
, beta ARK2
, beta-adrenergic receptor kinase 2
, G-protein-coupled receptor kinase 3
, adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase)
, G-protein coupled receptor kinase 2/3