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GRK3 controls cardiac alpha1-adrenergic receptor responsiveness
effects of GRK3 modulation appear to be specific to chemokine (show CCL1 ELISA Kits)-mediated migration behaviors without influencing tumor cell proliferation or survival
data are consistent with the possibility that oncogenes can induce cellular stiffness via an HDAC6 (show HDAC6 ELISA Kits)-induced reorganization of the vimentin (show VIM ELISA Kits) intermediate filament network
Data indicate that CXCL12 (show CXCL12 ELISA Kits)-induced phosphorylation at CXCR4 (show CXCR4 ELISA Kits) S346/347 was mediated by GRK2/3.
In oral squamous cell carcinomas, malignant cells and surrounding tissue overexpress the ADRBK2 gene.
A reduced cortical concentration of GRK3 in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia.
GRK3 is a negative regulator of cell growth whose expression is preferentially reduced in glioblastoma of the classical subtype as a consequence of activity in primary gliomagenic pathways.
mRNA levels for GRK3 were inversely correlated with systolic and diastolic blood pressure (day, night and 24 h), which suggests a protective role for GRK3 in the regulation of human blood pressure
we found no evidence of altered levels of acetylated histone H3 (show HIST3H3 ELISA Kits) at the affected allele compared to the common allele
dysregulation in GRK3 expression alters signaling desensitization, and thereby predisposes to the development of bipolar disorder
the CRH (show CRH ELISA Kits)-R1alpha carboxyl tail is important for regulation of receptor activity by G protein-coupled receptor (show ADRA1A ELISA Kits) kinase
beta-arrestin 2 (show ARRB2 ELISA Kits) and GRK2 (show ADRBK1 ELISA Kits) colocalize with S1p2 (show S1PR2 ELISA Kits) in developing zebrafish embryos and depletion of GRK2 (show ADRBK1 ELISA Kits) in the S1p2 (show S1PR2 ELISA Kits) R150H miles apart zebrafish partially rescued cardia bifida.
GRK2 (show ADRBK1 ELISA Kits) and GRK5 (show GRK5 ELISA Kits) control cardiac function as well as morphogenesis during development although with different morphological outcomes.
Data suggest that a G protein-coupled receptor (show GPBAR1 ELISA Kits) kinase, perhaps GRK2 (show ADRBK1 ELISA Kits) or 3, functions as a vertebrate kinase for Smoothened, promoting Hedgehog (show SHH ELISA Kits) signal transduction during early development.
These data thus reveal a novel kinase activity-independent function for GRK and establish a role for GRK2 as a cell-cycle regulator during early embryonic development.
Fusion proteins containing the c-terminus of GPCR kinase 3 (GRK3ct) and either the fluorescent protein cerulean or Renilla luciferase bind to venus-labeled Gbetagamma dimers, resulting in Forster or bioluminescence resonance energy transfer.
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
adrenergic, beta, receptor kinase 2
, beta-adrenergic receptor kinase 2-like
, beta ARK2
, beta-adrenergic receptor kinase 2
, G-protein-coupled receptor kinase 3
, adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase)
, G-protein coupled receptor kinase 2/3