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Review. Polymorphic variants in AXIN2 gene are discussed in relation to the occurrence of the tooth agenesis but also as an indication of the risk of cancer. Mutations in AXIN2 gene were found in patients with colorectal or hepatocellular carcinoma, prostate cancer, ovarian or lung cancer.
Consistent with bioinformatics predictions, SOX7 (show SOX7 Proteins) was correlated positively with AXIN2 and negatively with beta-catenin (show CTNNB1 Proteins), suggesting that SOX7 (show SOX7 Proteins) and AXIN2 might play important roles as co-regulators through the Wnt (show WNT2 Proteins)-beta-catenin (show CTNNB1 Proteins) pathway in the breast tissue to affect the carcinogenesis process.
we performed an association study of AXIN2, BMP4 (show BMP4 Proteins) and IRF6 (show IRF6 Proteins) gene SNPs with Non-Syndromic Cleft Lip with or without Cleft Palate in an Iranian population and the findings proposed that BMP4 (show BMP4 Proteins) rs17563 polymorphism is associated with reduced risk against Non-Syndromic Cleft Lip with or without Cleft Palate.
The results demonstrated miR (show MLXIP Proteins)-3120-5p promotes stemness and invasiveness of colon cancer cells through direct targeting of Axin2.
Hepatic Axin2 expressing CD90 (show THY1 Proteins)+ cells play a cancer stem cell-like role in the progression from liver cirrhosis to hepatocarcinoma.
role in the formation of degradasomes and degradation of beta-catenin (show CTNNB1 Proteins) induced by the TNKSi G007-LK in colorectal cancer cells
AXIN2 overexpression is associated with Breast Cancer Invasion and Metastasis.
the study reveals a strong association of SNPs in the Axin2 gene with lung cancer risk in North Indians.
Genetic variant in AXIN2 gene is associated with gallbladder cancer.
Data show that SS18 (show SS18 Proteins)/SSX (show SSX2 Proteins) tightly regulates the elevated expression of the key Wnt (show WNT2 Proteins) target AXIN2 in primary synovial sarcoma.
beta-catenin1 cannot revert the ich (show ACE Proteins) phenotype because it may be under the control of a GSK3beta-independent mechanism that required Axin's RGS (show PITX2 Proteins) domain function.
Study provides evidence that Axin2-expressing cells execute regeneration after skeletal injury.
identify Rap1b acting downstream of Axin2 as a signaling interrogator for FGF and BMP. Genetic analysis reveals that Rap1b is essential for development of craniofacial and body skeletons. Axin2 regulates Rap1b through modulation of canonical BMP signaling.
increased mesenchymal Wnt (show WNT2 Proteins) signaling inhibits the sequential formation of teeth, and suggest that Axin2/Runx2 (show RUNX2 Proteins) antagonistic interactions modulate the level of mesenchymal Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling, underlying the contrasting dental phenotypes caused by human AXIN2 and RUNX2 (show RUNX2 Proteins) mutations
we found that ESC-derived tissues at day 7 grown in Glasgow Minimum Expression Media (GMEM (show TNC Proteins)) containing knockout serum replacement (KSR (show KSR1 Proteins)) exhibited higher levels of expression of axin2, a Wnt (show WNT2 Proteins) target gene, than those grown in chemically defined medium
Barx2 (show BARX2 Proteins) and Pax7 (show PAX7 Proteins) regulate the canonical Wnt (show WNT2 Proteins) target gene Axin2, which mediates critical feedback to terminate the transcriptional response to Wnt (show WNT2 Proteins) signals.
Axin2 limits Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signalling after birth and allows proper heart valve maturation. Moreover, dysregulation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signalling resulting from loss of Axin2 leads to progressive myxomatous valve disease.
Wnt/beta-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers
Our results reveal a critical role for Axin2 during ocular development, likely by restricting the activity of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.
The role of Axin-2 signaling in the proliferation of undifferentiated spermatogonia in the adult mouse testis
Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
, axin-like protein
, axis inhibition protein 2
, axin 2 (conductin, axil)
, axin-related protein
, axin 2
, Axin-related protein