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increased abundance of Snail and Axin2 is highly correlated to malignant transformation of OL, making them novel biomarker(s) predicting oral cancer development
Review. Polymorphic variants in AXIN2 gene are discussed in relation to the occurrence of the tooth agenesis but also as an indication of the risk of cancer. Mutations in AXIN2 gene were found in patients with colorectal or hepatocellular carcinoma, prostate cancer, ovarian or lung cancer.
Consistent with bioinformatics predictions, SOX7 was correlated positively with AXIN2 and negatively with beta-catenin, suggesting that SOX7 and AXIN2 might play important roles as co-regulators through the Wnt-beta-catenin pathway in the breast tissue to affect the carcinogenesis process.
we performed an association study of AXIN2, BMP4 and IRF6 gene SNPs with Non-Syndromic Cleft Lip with or without Cleft Palate in an Iranian population and the findings proposed that BMP4 rs17563 polymorphism is associated with reduced risk against Non-Syndromic Cleft Lip with or without Cleft Palate.
The results demonstrated miR-3120-5p promotes stemness and invasiveness of colon cancer cells through direct targeting of Axin2.
Hepatic Axin2 expressing CD90+ cells play a cancer stem cell-like role in the progression from liver cirrhosis to hepatocarcinoma.
role in the formation of degradasomes and degradation of beta-catenin induced by the TNKSi G007-LK in colorectal cancer cells
AXIN2 overexpression is associated with Breast Cancer Invasion and Metastasis.
the study reveals a strong association of SNPs in the Axin2 gene with lung cancer risk in North Indians.
The genotype distribution of the rs1133683 polymorphism C> T showed a statistical difference between the two study groups ( p = 0.0019). individuals with either the C/T or T/T genotype have a decreased risk for colorectal cancer. For the rs2240308 polymorphism C > T, the OR analysis showed a significantly increased risk for carriers of the T/T genotype.
Genetic variant in AXIN2 gene is associated with gallbladder cancer.
Data show that SS18/SSX tightly regulates the elevated expression of the key Wnt target AXIN2 in primary synovial sarcoma.
our mutation analysis detected already known mutations as well as, to the best of our knowledge, mutations and an interstitial deletion of CTNNB1 not described in JAs before. Additionally, a so far unknown transcribed Axin2 splice variant was found, but no further Axin2 mutations.
miR-374a functions as an oncogene in osteosarcoma, and the miR-374a/Axin2 axis might represent a potential therapeutic target for OS intervention.
Flow cytometrically sorted CA9+ population showed increased mRNA level of a Wnt signaling factor AXIN2. In conclusion, these observations indicate that CA9 expression in normal crypt base cells has association with intestinal epithelial stemness
Increase in AXIN2 level expression is associated with breast cancer.
rs9675316 located on chr17q23-a24 near the AXIN2 gene was the most significantly associated with hallux valgus in males in genome-wide association meta-analyses.
Low AXIN2 was independently associated with more aggressive Prostate cancer , biochemical recurrence, and metastasis-free survival after Prostatectomies .
Axin2, a tumor suppressor, exhibited a marked inhibitory effect on Eca109 cell growth. The results identified a new role of miR-374a in esophageal cancer involving Axin2 suppression
study supports the relationship between AXIN2 mutation and non-syndromic oligodontia and extends the mutation spectrum of the AXIN2 gene.
beta-catenin1 cannot revert the ich phenotype because it may be under the control of a GSK3beta-independent mechanism that required Axin's RGS domain function.
Study provides evidence that Axin2-expressing cells execute regeneration after skeletal injury.
identify Rap1b acting downstream of Axin2 as a signaling interrogator for FGF and BMP. Genetic analysis reveals that Rap1b is essential for development of craniofacial and body skeletons. Axin2 regulates Rap1b through modulation of canonical BMP signaling.
increased mesenchymal Wnt signaling inhibits the sequential formation of teeth, and suggest that Axin2/Runx2 antagonistic interactions modulate the level of mesenchymal Wnt/beta-catenin signaling, underlying the contrasting dental phenotypes caused by human AXIN2 and RUNX2 mutations
we found that ESC-derived tissues at day 7 grown in Glasgow Minimum Expression Media (GMEM) containing knockout serum replacement (KSR) exhibited higher levels of expression of axin2, a Wnt target gene, than those grown in chemically defined medium
Barx2 and Pax7 regulate the canonical Wnt target gene Axin2, which mediates critical feedback to terminate the transcriptional response to Wnt signals.
Axin2 limits Wnt/beta-catenin signalling after birth and allows proper heart valve maturation. Moreover, dysregulation of Wnt/beta-catenin signalling resulting from loss of Axin2 leads to progressive myxomatous valve disease.
Wnt/beta-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers
Our results reveal a critical role for Axin2 during ocular development, likely by restricting the activity of the Wnt/beta-catenin pathway.
The role of Axin-2 signaling in the proliferation of undifferentiated spermatogonia in the adult mouse testis
Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt/beta-catenin signaling.
Axin2-expressing prostatic cells express epithelial cell markers and are able to expand cell lineage during prostatic development and maturation.
Axin1 and Axin2 do not have equivalent functions in satellite cells, but are both involved in repression of Wnt/beta-catenin signalling to maintain proliferation and contribute to controlling timely myogenic differentiation.
These data demonstrate a dominant role for Runx2 in chondrocyte maturation, but implicate Axin2 as an important modulator of the terminal stages of endochondral bone formation.
implants lacking primary stability undergo osseointegration, provided Wnt signalling is amplified. Fibrous encapsulation can be prevented and osseointegration assured if Wnt signalling is elevated at the time of implant placement.
Axin2(-/-) PF-sutures lack physiological endochondral ossification
Axin2(+) cells can give rise to spatially and functionally restricted populations of adult neural stem cells in the subventricular zone.
Axin2-positive tympanic border cells are Wnt responsive and can act as precursors to sensory epithelial cells in the postnatal cochlea.
Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice
Data show that expression of Brachyury targets Axin2, Fgf8 and Wnt3a, is down regulated in Brachyury mutant embryos.
Lgr5 and Axin2 differential expression among cell populations highlights the dynamic but complex distribution of Wnt-activated cells in and around the embryonic and postnatal cochlea.
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
, axin-like protein
, axis inhibition protein 2
, axin 2 (conductin, axil)
, axin-related protein
, axin 2
, Axin-related protein