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anti-Human Mahogunin RING Finger Protein 1 Antibodies:
anti-Mouse (Murine) Mahogunin RING Finger Protein 1 Antibodies:
anti-Rat (Rattus) Mahogunin RING Finger Protein 1 Antibodies:
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epletion of MGRN1 activity may hamper physiologically important processes like mitochondrial movement in neuronal processes and intracellular transport of ligands through the endosomal pathway thereby contributing to the pathogenesis of neurodegeneration in certain types of prion (show PRNP Antibodies) diseases
In a heterologous expression system, MC1R (show MSHR Antibodies)-dependent Arrestins B ubiquitination was enhanced by overexpression of MGRN1 and was impaired by siRNA-mediated MGRN1 knockdown thus pointing to MGRN1 as the responsible E3-ligase.
Hypomethylation of CpG sites in RPTOR (show RPTOR Antibodies), MGRN1 and RAPSN (show RAPSN Antibodies) in blood is associated with breast cancer.
Regulation of Mfn1 (show MFN1 Antibodies) by MGRN1 and the proteasome modulates mitochondrial fusion.
With aging, the neuroprotective e3 ligase MGRN1 relocates from the cytosol to the nucleus of neurons, where it associates with chromatin and potentiates the cellular response to proteotoxic stress. This nuclear shift is due to a proteasome impairment dependent increase of a monoubiquitinated form of MGRN1.
Catalytic inactivation of MGRN1 results in elevated levels of GP78 (show AMFR Antibodies) and a consequential increase in the initiation of mitophagy.
Mahogunin-mediated alpha-tubulin (show TUBA4A Antibodies) ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation.
data suggest that MGRN1 selectively targets misfolded proteins for degradation and may exhibit viable therapeutic potential for the treatment of spongiform neurodegeneration
It therefore seems probable that the role of MGRN1 in the adrenal relates to the trafficking and/or degradation of the melanocortin 2 receptor (show MC2R Antibodies).
a role for Mahogunin in a proteasome-independent ubiquitylation pathway: TSG101 (show TSG101 Antibodies) is a specific Mahogunin substrate
Mgrn1 can negatively regulate signaling through the Hedgehog (show SHH Antibodies) pathway by reducing cell-surface and ciliary levels of Smoothened, an oncoprotein that transmits the Hedgehog (show SHH Antibodies) signal across the membrane.
Findings suggest that mahogunin ring finger-1 contributes to the clearance of toxic mutant copper-zinc superoxide dismutase (show SOD1 Antibodies) inclusions likely through autophagic pathway.
ATRN (show ATRN Antibodies) also has no effect on prion (show PRNP Antibodies) disease onset or progression and discuss possible mechanisms that could cause vacuolation of the central nervous system in Mgrn1 and Atrn (show ATRN Antibodies) null mutant mice
pigment-type switching likely requires MGRN1's ubiquitin ligase activity but not its ability to bind TSG101 or NEDD4.
Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase (show MUL1 Antibodies) do not influence prion (show PRNP Antibodies) disease.
the md and mg mutations rescue the A(y) phenotypes by a primarily cAMP-independent mechanism promoting trafficking of MC4R (show MC4R Antibodies) and likely MC1R (show MSHR Antibodies) away from the lysosome toward the cell surface.
positional cloning of mahoganoid, encoding a novel 494-amino acid protein containing a C3HC4 RING (really interesting new gene) domain that may function as an E3 ubiquitin ligase (show MUL1 Antibodies)
a null mutation for mahoganoid causes a similar age-dependent neuropathology that includes many features of prion (show PRNP Antibodies) diseases but without accumulation of protease-resistant prion protein (show PRNP Antibodies)
Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.
E3 ubiquitin-protein ligase MGRN1
, RING finger protein 156
, mahogunin RING finger protein 1
, mahogunin, ring finger 1
, probable E3 ubiquitin-protein ligase MGRN1
, mahogunin ring finger protein 1