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Galanin, acting via the GAL1 (show LGALS1 Proteins) receptor and Gi -coupled signalling in L and K cells, is a potent inhibitor of GLP-1 (show GCG Proteins) and GIP (show GIP Proteins) secretion
Galanin released by cancer induces neuritogenesis, facilitating perineural invasion.
Study shows that LIF (show LIF Proteins)-treated postmitotic oligodendrocytes secrete a number of neuropeptides, in particular galanin, at the mRNA and peptide level, and galanin itself was shown to be a survival factor for oligodendrocytes
Results suggest that GAL is a regulator of myelination, as demonstrated by MBP (show MBP Proteins) synthesis, and may be one of the myelination promoters
Oleuropein protects mice from gh-fat diet induced adiposity by upregulation of genes involved in WNT10b (show WNT10B Proteins)-mediated signaling and downregulation of genes involved in galanin-mediated signaling cascades.
medial preoptic area galanin neurons emerge as an essential regulatory node of male and female parenting behaviour and other social responses
Analysis of the gene proximal region using EMSA and ChIP assays showed that CREB (show CREB1 Proteins) protein interacts with the galanin promoter both in vitro and in vivo. Additional EMSA analysis revealed that an SP1 (show SP1 Proteins) consensus site mediated protein-DNA complex formation.
The expression of mRNA galanin is increased following chronic restraint stress.
These results suggest that sertraline-related galanin induction in ventral dentate gyrus may play an important role in therapeutic mechanisms for depression.
extended perifornical area galanin-LepRb (show LEPR Proteins) neurons galanin acts inhibitory rather than orexigenic
Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion.